MX2021010357A - Proceso para cuantificacion de polisorbato en una muestra que implica lc-ms con un estandar interno. - Google Patents

Proceso para cuantificacion de polisorbato en una muestra que implica lc-ms con un estandar interno.

Info

Publication number
MX2021010357A
MX2021010357A MX2021010357A MX2021010357A MX2021010357A MX 2021010357 A MX2021010357 A MX 2021010357A MX 2021010357 A MX2021010357 A MX 2021010357A MX 2021010357 A MX2021010357 A MX 2021010357A MX 2021010357 A MX2021010357 A MX 2021010357A
Authority
MX
Mexico
Prior art keywords
internal standard
sample
sample involving
polysorbate
quantification
Prior art date
Application number
MX2021010357A
Other languages
English (en)
Inventor
Pierre Guibal
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2021010357A publication Critical patent/MX2021010357A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/626—Detectors specially adapted therefor calibration, baseline
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente solicitud se relaciona a un proceso para cuantificar los polisorbatos en una muestra por implementar un análisis de LC-MS con un estándar interno, y el proceso para monitorear la degradación de polisorbatos en la muestra.
MX2021010357A 2019-02-27 2020-02-27 Proceso para cuantificacion de polisorbato en una muestra que implica lc-ms con un estandar interno. MX2021010357A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19305232 2019-02-27
PCT/EP2020/055191 WO2020174064A1 (en) 2019-02-27 2020-02-27 Process for polysorbate quantification in a sample involving lc-ms with an internal standard

Publications (1)

Publication Number Publication Date
MX2021010357A true MX2021010357A (es) 2021-09-30

Family

ID=65991721

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021010357A MX2021010357A (es) 2019-02-27 2020-02-27 Proceso para cuantificacion de polisorbato en una muestra que implica lc-ms con un estandar interno.

Country Status (13)

Country Link
US (1) US11796519B2 (es)
EP (1) EP3931572A1 (es)
JP (1) JP2022521628A (es)
KR (1) KR20210133222A (es)
CN (1) CN113490851A (es)
AU (1) AU2020229063A1 (es)
BR (1) BR112021016130A2 (es)
CA (1) CA3130408A1 (es)
IL (1) IL285735A (es)
MX (1) MX2021010357A (es)
SG (1) SG11202109001UA (es)
TW (1) TW202045927A (es)
WO (1) WO2020174064A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022420630A1 (en) 2021-12-20 2024-05-02 Boehringer Ingelheim International Gmbh Method for determining the degree of oxidative degradation of polysorbate 20 in aqueous formulations
CN115304227B (zh) * 2022-07-15 2023-12-15 中国地质大学（武汉） 一种污泥中溶解性有机物分子组成的解析方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05007654A (es) * 2003-01-17 2005-09-30 Danisco Metodo.
EP2802670B1 (en) * 2011-11-08 2019-12-25 University of Washington Lysosomal enzyme assay methods and compositions
WO2013182217A1 (en) * 2012-04-27 2013-12-12 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
WO2013175312A1 (en) 2012-05-23 2013-11-28 Glaxosmithkline Biologicals Sa Method for determining a concentration of a polysorbate species in a mixture
US20150141415A1 (en) * 2013-11-20 2015-05-21 Omonike Arike Olaleye Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
US10564076B2 (en) * 2015-06-16 2020-02-18 Agilent Technologies, Inc. Compositions and methods for analytical sample preparation
AU2017312540B2 (en) * 2016-08-15 2023-02-02 Genentech, Inc. Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide
RU2670965C9 (ru) * 2017-12-14 2018-11-21 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Способ измерения количества полисорбата-80 с применением щелочного гидролиза образца с последующей вэжх
CA3172898A1 (en) * 2020-02-27 2021-09-02 Regeneron Pharmaceuticals, Inc. Methods of reducing polysorbate degradation in drug formulations

Also Published As

Publication number Publication date
JP2022521628A (ja) 2022-04-11
BR112021016130A2 (pt) 2021-10-13
AU2020229063A1 (en) 2021-09-09
CN113490851A (zh) 2021-10-08
IL285735A (en) 2021-10-31
SG11202109001UA (en) 2021-09-29
US11796519B2 (en) 2023-10-24
TW202045927A (zh) 2020-12-16
US20220120720A1 (en) 2022-04-21
WO2020174064A1 (en) 2020-09-03
CA3130408A1 (en) 2020-09-03
EP3931572A1 (en) 2022-01-05
KR20210133222A (ko) 2021-11-05

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