MX2021005767A - Composiciones de nanoemulsiones que tienen una permeabilidad mejorada. - Google Patents

Composiciones de nanoemulsiones que tienen una permeabilidad mejorada.

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Publication number
MX2021005767A
MX2021005767A MX2021005767A MX2021005767A MX2021005767A MX 2021005767 A MX2021005767 A MX 2021005767A MX 2021005767 A MX2021005767 A MX 2021005767A MX 2021005767 A MX2021005767 A MX 2021005767A MX 2021005767 A MX2021005767 A MX 2021005767A
Authority
MX
Mexico
Prior art keywords
enhanced permeability
compositions
nanoemulsion compositions
nanoemulsion
mucosal
Prior art date
Application number
MX2021005767A
Other languages
English (en)
Inventor
Susan Ciotti
David Peralta
Original Assignee
Bluewillow Biologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bluewillow Biologics Inc filed Critical Bluewillow Biologics Inc
Publication of MX2021005767A publication Critical patent/MX2021005767A/es

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    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
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    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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Abstract

La presente descripción se refiere a composiciones de nanoemulsión con ciertas proporciones de mezcla de agentes tensoactivos que imparten una permeabilidad mejorada; tales composiciones son útiles para aplicaciones tópica, mucosal, vaginal, e intranasal y permiten el mayor suministro de uno o más agentes activos al sitio de la aplicación.
MX2021005767A 2018-11-15 2019-11-14 Composiciones de nanoemulsiones que tienen una permeabilidad mejorada. MX2021005767A (es)

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PCT/US2019/061408 WO2020102494A1 (en) 2018-11-15 2019-11-14 Nanoemulsion compositions having enhanced permeability

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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200237815A1 (en) * 2017-02-24 2020-07-30 Alain Martin Methods for treatment of lung damage and for inhibition of lung fibrosis
EP4121026A4 (en) * 2020-03-17 2024-04-10 Bluewillow Biologics, Inc. PERSISTENT TOPICAL ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF
US11744866B2 (en) 2020-03-18 2023-09-05 Sabine Hazan Methods of preventing and treating COVID-19 infection with probiotics
US11253534B2 (en) 2020-03-23 2022-02-22 Sabine Hazan Method of preventing COVID-19 infection
US11278520B2 (en) 2020-03-31 2022-03-22 Sabine Hazan Method of preventing COVID-19 infection
EP4117684A4 (en) * 2020-04-20 2023-10-04 Poviva Corp. COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF ANTIVIRAL AGENTS
US20220040098A1 (en) * 2020-08-10 2022-02-10 Quimica Luar S.R.L. Methods for treating respiratory viral infections
WO2022035911A2 (en) * 2020-08-11 2022-02-17 Tutela Pharmaceuticals, Inc. Methods of treating coronavirus infections by co-administering an fkbp ligand and an antiviral agent
CN111909261B (zh) * 2020-08-19 2022-10-04 重庆医科大学 新冠病毒rbd特异性单克隆抗体和应用
CN111925442B (zh) * 2020-08-19 2022-10-11 重庆医科大学 新冠病毒rbd特异性单克隆抗体和应用
CN118206645A (zh) * 2020-08-19 2024-06-18 重庆医科大学 新型冠状病毒rbd特异性单克隆抗体和应用
CN111991374A (zh) * 2020-08-20 2020-11-27 大连理工大学 一种瑞德西韦吸入气雾剂及其制备方法
WO2022051713A1 (en) * 2020-09-04 2022-03-10 The University Of Chicago Materials and methods of treating viral infection with amphiphilic block copolymers
AU2021341483A1 (en) * 2020-09-14 2023-04-20 Istanbul Universitesi Rektorlugu Use of active substances with antiviral, anti malarial, and/or mucolytic properties in the treatment of viral lung diseases including covid-19 by soft mist inhaler or vibration mesh technology nebulizer through inhalation route
US20220090167A1 (en) * 2020-09-15 2022-03-24 University Of Notre Dame Du Lac Asymmetric nanopore membrane (anm) filtration for high-efficiency virus enrichment and purification
US20230381125A1 (en) * 2020-09-25 2023-11-30 The Regents Of The University Of California Compositions and methods for ameliorating medical conditions
US20230364038A1 (en) * 2020-09-29 2023-11-16 Lighthouse Pharma GmbH Anti-infective dosage forms for producing a nasal rinse
WO2022082093A1 (en) * 2020-10-16 2022-04-21 Neonc Technologies, Inc. Combination of poh and remdesivir for treatment of cns infections
IT202000025207A1 (it) * 2020-10-23 2022-04-23 Antonio Bianchi Formulazione spray per uso nasale/orale con attivita’ contro i coronavirus respiratori
IT202100016037A1 (it) * 2021-06-18 2021-09-18 Antonio Bianchi Formulazione spray per uso nasale/orale con attivita’ contro i coronavirus respiratori
WO2022084931A1 (en) * 2020-10-23 2022-04-28 Antonio Bianchi Spray formulation for nasal/oral use with activity against respiratory coronaviruses and in particular the sars-cov-2 virus
WO2022091122A1 (en) * 2020-10-26 2022-05-05 Cipla Limited Stable remdesivir formulations
WO2022093141A1 (en) 2020-10-30 2022-05-05 Erdogmus Hueseyin Antiviral essential oil compositions
KR20220067429A (ko) * 2020-11-17 2022-05-24 서울대학교산학협력단 레인(rhein), 메클로페남산(meclofenamic acid), 또는 이들의 조합을 포함하는 SARS-CoV-2 및 HCoV-OC43에 대한 항바이러스용 조성물
WO2022123433A1 (en) * 2020-12-08 2022-06-16 Lupin Limited Oral pharmaceutical compositions of remdesivir
CN112501356B (zh) * 2020-12-16 2022-06-17 山东省动物疫病预防与控制中心 一种水貂冠状病毒与新型冠状病毒快速鉴别检测的探针引物组、试剂盒及其检测方法
CA3106787A1 (en) * 2021-01-22 2022-07-22 Amphotericin B Technologies Inc. Use of amphotericin b in the treatment of coronavirus diseases
CN112656759B (zh) * 2021-01-23 2022-08-19 河南泰丰生物科技有限公司 一种瑞德西韦滴眼剂及其制备方法和用途
RU2754531C1 (ru) * 2021-03-24 2021-09-03 Павел Владимирович Сорокин Применение способа введения натриевой соли 2-метилтио-6-нитро-1,2-4-триазоло[5,1-с]-1,2,4-триазин-7-она, дигидрата, обладающей противовирусной активностью, для профилактики коронавирусной инфекции COVID-19
RU2754532C1 (ru) * 2021-03-24 2021-09-03 Павел Владимирович Сорокин Применение способа введения натриевой соли 2-метилтио-6-нитро-1,2-4-триазоло[5,1-с]-1,2,4-триазин-7-она, дигидрата, обладающей противовирусной активностью, для лечения коронавирусной инфекции COVID-19
CN113092624A (zh) * 2021-04-07 2021-07-09 河南泰丰生物科技有限公司 瑞德西韦有关物质及含量测定方法
WO2022258125A1 (en) * 2021-06-09 2022-12-15 Elmallah Ahmed Ibrahim Mohamed Elsayed Pharmaceutical compositions of vanillin and wheat germ oil for treatment of covid-19 viral infection and methods of preparation
US11724077B2 (en) * 2021-07-28 2023-08-15 Subhash Dhawan Therapeutic swabs for treating upper respiratory infections
KR102526308B1 (ko) * 2022-06-23 2023-04-27 한국 한의학 연구원 한약재 추출물을 유효성분으로 포함하는 코로나바이러스 감염증의 예방, 개선 또는 치료용 조성물
WO2024059842A2 (en) * 2022-09-16 2024-03-21 Augusta University Research Institute, Inc. Compositions and methods of minimizing long covid
CN116098893B (zh) * 2023-01-17 2024-03-26 中国农业科学院兰州兽医研究所 化合物Thapsigargin在制备预防或治疗猪流行性腹泻药物中的应用
CN116036065B (zh) * 2023-01-17 2024-03-26 中国农业科学院兰州兽医研究所 化合物egta在制备预防或治疗猪流行性腹泻药物中的应用
DE102023114609A1 (de) 2023-03-02 2024-09-05 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mit beschränkter Haftung Zusammensetzung für die antivirale Behandlung

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895452A (en) 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5103497A (en) 1989-11-14 1992-04-07 Hicks John W Flying spot endoscope
BR9507669A (pt) * 1994-05-20 1997-10-07 Novavax Inc Emulsões de óleo em água antibacteriais
US6015832A (en) 1997-12-31 2000-01-18 The Regents Of The University Of Michigan Methods of inactivating bacteria including bacterial spores
US7767216B2 (en) 1999-04-28 2010-08-03 The Regents Of The University Of Michigan Antimicrobial compositions and methods of use
US8232320B2 (en) 1999-04-28 2012-07-31 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
US6506803B1 (en) 1999-04-28 2003-01-14 Regents Of The University Of Michigan Methods of preventing and treating microbial infections
US6635676B2 (en) 1999-04-28 2003-10-21 Regents Of The University Of Michigan Non-toxic antimicrobial compositions and methods of use
US6559189B2 (en) 1999-04-28 2003-05-06 Regents Of The University Of Michigan Non-toxic antimicrobial compositions and methods of use
US7655252B2 (en) 1999-04-28 2010-02-02 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
AU2002367976B2 (en) * 2001-06-05 2007-06-21 The Regents Of The University Of Michigan Nanoemulsion vaccines
US20050208083A1 (en) 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
CA2618974C (en) * 2005-08-09 2014-01-28 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
US9839685B2 (en) 2006-04-13 2017-12-12 The Regents Of The University Of Michigan Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen
EP2152304B1 (en) 2007-05-02 2018-08-22 The Regents of the University of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2009131995A1 (en) * 2008-04-21 2009-10-29 Nanobio Corporation Nanoemulsion influenza vaccine
CA2722445A1 (en) * 2008-04-25 2009-10-29 Nanobio Corporation Nanoemulsions for treating fungal, yeast and mold infections
EP2293813A4 (en) 2008-05-23 2012-07-11 Univ Michigan NANOEMULSION VACCINES
JP5722782B2 (ja) 2008-09-26 2015-05-27 ナノバイオ コーポレーション ナノエマルジョン治療用組成物及びその使用方法
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US20100226983A1 (en) 2009-01-28 2010-09-09 Nanobio Corporation Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof
WO2010132833A1 (en) 2009-05-14 2010-11-18 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
US20120003277A1 (en) * 2010-07-02 2012-01-05 Nanobio Corporation Nanoemulsion vaccines
US20120064136A1 (en) * 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
EP2729169A1 (en) 2011-07-06 2014-05-14 Nanobio Corporation Human respiratory syncytial virus vaccine
CA2845872C (en) 2011-08-22 2023-03-28 Nanobio Corporation Herpes simplex virus nanoemulsion vaccine
WO2013036907A1 (en) 2011-09-09 2013-03-14 Nanobio Corporation Nanoemulsion respiratory syncytial virus (rsv) subunit vaccine
US20170100335A1 (en) * 2014-03-21 2017-04-13 The Regents Of The University Of Michigan Topical nanoemulsion therapy for wounds
JP2018511655A (ja) 2015-03-20 2018-04-26 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ボルデテラ属に対するワクチン接種における使用のための免疫原性組成物
US11173197B2 (en) 2015-07-07 2021-11-16 Bluewillow Biologics, Inc. Methods and compositions for nanoemulsion vaccine formulations
JP2018521129A (ja) 2015-07-07 2018-08-02 ナノビオ コーポレイションNanobio Corporation タンパク質の安定化のための方法および組成物
US20170007690A1 (en) 2015-07-07 2017-01-12 Nanobio Corporation Methods and compositions for the stabilization of anthrax recombinant protective antigen
EP3328359A4 (en) 2015-07-31 2019-03-27 NanoBio Corporation PROCESS FOR TREATING ACNE WITH NANOEMULSION COMPOSITIONS
EP3454891A4 (en) 2016-05-10 2019-12-25 The Regents of The University of Michigan EMULSION ADDITIVE FOR INTRAMUSCULAR, INTRADERMAL AND SUBCUTANEOUS ADMINISTRATION
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions

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