MX2021004758A - Agente terapeutico para el trastorno de cartilago. - Google Patents
Agente terapeutico para el trastorno de cartilago.Info
- Publication number
- MX2021004758A MX2021004758A MX2021004758A MX2021004758A MX2021004758A MX 2021004758 A MX2021004758 A MX 2021004758A MX 2021004758 A MX2021004758 A MX 2021004758A MX 2021004758 A MX2021004758 A MX 2021004758A MX 2021004758 A MX2021004758 A MX 2021004758A
- Authority
- MX
- Mexico
- Prior art keywords
- cartilage
- cartilage disorder
- treating
- disorder
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Los inventores de la presente invención buscaron una sustancia que fuera eficaz en el tratamiento de un trastorno del cartílago y, como resultado, encontraron que, en un modelo animal de deficiencia de cartílago articular, un péptido del fragmento HMGB1 que tiene una secuencia de aminoácidos específica exhibe el efecto de reproducir un tejido de cartílago sano, incluido un cartílago hialino; basándose en este hallazgo, la presente invención proporciona una composición farmacéutica que contiene el péptido del fragmento de HMGB1 específico y que sirve para prevenir y/o tratar un trastorno del cartílago.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018200866 | 2018-10-25 | ||
| PCT/JP2019/042015 WO2020085506A1 (ja) | 2018-10-25 | 2019-10-25 | 軟骨疾患の治療薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021004758A true MX2021004758A (es) | 2021-08-24 |
Family
ID=70331194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021004758A MX2021004758A (es) | 2018-10-25 | 2019-10-25 | Agente terapeutico para el trastorno de cartilago. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210386823A1 (es) |
| EP (1) | EP3865179A4 (es) |
| JP (1) | JP7448126B2 (es) |
| KR (1) | KR20210082478A (es) |
| CN (1) | CN113423466A (es) |
| AU (1) | AU2019367943A1 (es) |
| BR (1) | BR112021007732A2 (es) |
| CA (1) | CA3117107A1 (es) |
| IL (1) | IL282377A (es) |
| MX (1) | MX2021004758A (es) |
| SG (1) | SG11202104015YA (es) |
| WO (1) | WO2020085506A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024005133A1 (ja) * | 2022-06-30 | 2024-01-04 | 国立大学法人大阪大学 | 半月板の治療薬 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156851A1 (en) * | 2002-11-20 | 2004-08-12 | Critical Therapeutics, Inc. | HMGB1 combination therapies |
| BRPI0514835A (pt) * | 2004-09-03 | 2008-06-24 | Creabilis Therapeutics Spa | variante de polipetìdeo de box de domìnio de ligação por alta afinidade de hmbg1 humano e/ou não humano ou de fragmento biologicamente ativo de box-a de hmgb1, molécula de ácido nucléico, uso, composição farmacêutica e dispositivo médico |
| CN101528266B (zh) * | 2006-09-15 | 2012-11-07 | 克雷毕里斯治疗股份公司 | Hmgb1的a盒和hmgb1的a盒变体的聚合体缀合物 |
| JP2010503630A (ja) * | 2006-09-15 | 2010-02-04 | クレアビリス・セラピューティクス・エスピーエー | ＨＭＧＢ１のＢｏｘ−ＡおよびＨＭＧＢ１のＢｏｘ−Ａ変異体のポリマー複合体 |
| RU2571230C2 (ru) * | 2008-04-30 | 2015-12-20 | Дженомикс Ко., Лтд. | Способ сбора функциональных клеток in vivo с высокой эффективностью |
| DK2703487T3 (en) * | 2011-04-26 | 2018-09-10 | Genomix Co Ltd | TIME TO INDUCTION Tissue Regeneration and its Use |
| AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
| JP6253590B2 (ja) * | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Ｈｍｇｂ１断片を利用した脊髄の損傷に対する新規治療法 |
| JP7182162B2 (ja) | 2017-01-27 | 2022-12-02 | 株式会社ステムリム | 心筋症、陳旧性心筋梗塞および慢性心不全の治療薬 |
| CN110621331A (zh) | 2017-04-07 | 2019-12-27 | 斯特姆里姆有限公司 | 纤维化疾病的治疗药物 |
| AU2018257071B2 (en) * | 2017-04-25 | 2021-11-11 | Shionogi & Co., Ltd. | Peptide for inducing regeneration of tissue, and use thereof |
| US11196087B2 (en) | 2017-05-19 | 2021-12-07 | Panasonic Intellectual Property Management Co., Ltd. | Nonaqueous electrolyte containing perfluoropolyether and nitrile compound, and secondary battery including the same |
| WO2019107566A1 (ja) * | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | 外胚葉性間葉系幹細胞およびその製造方法 |
| EP3750553A4 (en) * | 2018-02-08 | 2022-01-12 | Stemrim Inc. | THERAPEUTIC FOR PSORIASIS |
-
2019
- 2019-10-25 JP JP2020552636A patent/JP7448126B2/ja active Active
- 2019-10-25 BR BR112021007732-4A patent/BR112021007732A2/pt unknown
- 2019-10-25 AU AU2019367943A patent/AU2019367943A1/en active Pending
- 2019-10-25 KR KR1020217015301A patent/KR20210082478A/ko unknown
- 2019-10-25 EP EP19875071.3A patent/EP3865179A4/en active Pending
- 2019-10-25 MX MX2021004758A patent/MX2021004758A/es unknown
- 2019-10-25 CA CA3117107A patent/CA3117107A1/en active Pending
- 2019-10-25 WO PCT/JP2019/042015 patent/WO2020085506A1/ja unknown
- 2019-10-25 CN CN201980085703.XA patent/CN113423466A/zh active Pending
- 2019-10-25 US US17/287,636 patent/US20210386823A1/en active Pending
- 2019-10-25 SG SG11202104015YA patent/SG11202104015YA/en unknown
-
2021
- 2021-04-18 IL IL282377A patent/IL282377A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3865179A4 (en) | 2022-07-27 |
| CA3117107A1 (en) | 2020-04-30 |
| BR112021007732A2 (pt) | 2021-08-03 |
| CN113423466A (zh) | 2021-09-21 |
| US20210386823A1 (en) | 2021-12-16 |
| SG11202104015YA (en) | 2021-05-28 |
| IL282377A (en) | 2021-06-30 |
| AU2019367943A1 (en) | 2021-05-27 |
| JP7448126B2 (ja) | 2024-03-12 |
| JPWO2020085506A1 (ja) | 2021-09-16 |
| KR20210082478A (ko) | 2021-07-05 |
| WO2020085506A1 (ja) | 2020-04-30 |
| EP3865179A1 (en) | 2021-08-18 |
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