MX2021004187A - Métodos y composiciones para editar ácidos ribonucleicos. - Google Patents

Métodos y composiciones para editar ácidos ribonucleicos.

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Publication number
MX2021004187A
MX2021004187A MX2021004187A MX2021004187A MX2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A
Authority
MX
Mexico
Prior art keywords
methods
compositions
editing
rna
rnas
Prior art date
Application number
MX2021004187A
Other languages
English (en)
Inventor
Chunhui Wang
Wensheng Wei
Liang Qu
Zongyi Yi
Shiyou Zhu
Zhongzheng Cao
Zhuo Zhou
Pengfei Yuan
Original Assignee
Edigene Therapeutics Beijing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edigene Therapeutics Beijing Inc filed Critical Edigene Therapeutics Beijing Inc
Publication of MX2021004187A publication Critical patent/MX2021004187A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
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  • Mycology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
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Abstract

La presente solicitud proporciona métodos para editar ARN mediante la introducción de un ARN de reclutamiento de desaminasas en una célula hospedera para la desaminación de una adenosina en un ARN objetivo; la presente solicitud proporciona además ARN de reclutamiento de desaminasas usados en los métodos de edición de ARN y composiciones que los comprenden.
MX2021004187A 2018-10-12 2019-10-12 Métodos y composiciones para editar ácidos ribonucleicos. MX2021004187A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018110105 2018-10-12
CN2019082713 2019-04-15
PCT/CN2019/110782 WO2020074001A1 (en) 2018-10-12 2019-10-12 Methods and Compositions for Editing RNAs

Publications (1)

Publication Number Publication Date
MX2021004187A true MX2021004187A (es) 2021-09-08

Family

ID=70163607

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004187A MX2021004187A (es) 2018-10-12 2019-10-12 Métodos y composiciones para editar ácidos ribonucleicos.

Country Status (21)

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US (2) US20210355494A1 (es)
EP (2) EP3864152B1 (es)
JP (2) JP7252328B2 (es)
KR (1) KR102666695B1 (es)
CN (4) CN113631708B (es)
AU (2) AU2019357450B2 (es)
BR (1) BR112021006844A8 (es)
CA (1) CA3115864A1 (es)
CL (1) CL2021000880A1 (es)
CO (1) CO2021005956A2 (es)
CR (1) CR20210243A (es)
DK (1) DK3864152T5 (es)
EC (1) ECSP21033637A (es)
ES (1) ES2962434T3 (es)
IL (1) IL282191A (es)
MX (1) MX2021004187A (es)
PE (1) PE20211402A1 (es)
PH (1) PH12021550805A1 (es)
SG (1) SG11202103666PA (es)
TW (1) TW202028466A (es)
WO (1) WO2020074001A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3589751A4 (en) 2017-03-03 2021-11-17 The Regents of The University of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR RNA AND DEAMINASES
CA3127241A1 (en) 2019-01-22 2020-07-30 Korro Bio, Inc. Rna-editing oligonucleotides and uses thereof
US20220307020A1 (en) 2019-04-15 2022-09-29 Edigene Inc. Methods and compositions for editing rnas
KR20220038706A (ko) 2019-07-12 2022-03-29 페킹 유니버시티 조작된 rna를 사용한 내인성 adar을 활용한 타겟 rna 편집
CA3159944A1 (en) 2019-12-02 2021-06-10 David HUSS Therapeutic editing
TW202138561A (zh) 2019-12-30 2021-10-16 大陸商博雅輯因（北京）生物科技有限公司 治療Usher綜合症的方法和其組合物
CN114846139A (zh) 2019-12-30 2022-08-02 北京辑因医疗科技有限公司 一种基于leaper技术治疗mps ih的方法和组合物
PE20230703A1 (es) * 2020-04-15 2023-04-24 Edigene Therapeutics Beijing Inc Metodo y farmaco para tratar el sindrome de hurler
US20210380980A1 (en) * 2020-05-28 2021-12-09 Korro Bio, Inc. Methods and Compositions for the ADAR-Mediated Editing of SERPINA1
CN113897359A (zh) * 2020-07-06 2022-01-07 博雅辑因（北京）生物科技有限公司 一种改善的rna编辑方法
CA3185231A1 (en) 2020-07-06 2022-01-13 Pengfei YUAN Improved rna editing method
IL278401A (en) 2020-10-29 2022-05-01 Yeda Res & Dev Polynucleotides for editing RNA and a method for using them
EP4240338A1 (en) * 2021-01-04 2023-09-13 The Regents of The University of California <smallcaps/>? ? ?in vivo? ? ? ? ?programmable rna editingvia recruitment of endogenous adars
CN117015605A (zh) * 2021-01-12 2023-11-07 北京大学 使用工程化rna通过利用内源性adar进行靶向rna编辑
AU2022291759A1 (en) * 2021-06-15 2023-12-21 Massachusetts Institute Of Technology Deaminase-based rna sensors
EP4363576A1 (en) * 2021-06-29 2024-05-08 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides
CN118202045A (zh) * 2021-08-18 2024-06-14 北京大学 工程化的adar募集rna及其使用方法
TW202321440A (zh) 2021-10-07 2023-06-01 美商肝特斯公司 追蹤接受者中之供體細胞之方法
WO2023077138A1 (en) * 2021-10-29 2023-05-04 Duke Univeristy Compositions and systems for rna-programable cell editing and methods of making and using same
WO2023143539A1 (en) * 2022-01-28 2023-08-03 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use thereof
WO2023185231A1 (en) * 2022-04-02 2023-10-05 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use for usher syndrome
WO2024086650A1 (en) * 2022-10-18 2024-04-25 Locanabio, Inc. Compositions and methods comprising programmable snrnas for rna editing
CN118620958A (zh) * 2023-03-08 2024-09-10 广州医科大学 一种抗原表位的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101297830B1 (ko) * 2010-09-10 2013-08-19 한국생명공학연구원 신규한 ｒｎａ 결합 단백질 및 이를 이용한 무표지 마이크로 ｒｎａ 검출방법
EP3230445B1 (en) * 2014-12-12 2024-01-24 Tod M. Woolf Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
CN107109413B (zh) * 2014-12-17 2021-03-09 ProQR治疗上市公司Ⅱ 靶向的rna编辑
EP3323890A4 (en) * 2015-07-14 2019-01-30 Fukuoka University METHOD FOR INDUCING SITE SPECIFIC RNA MUTATIONS, TARGET EDITION GUIDING RNA-GUIDE USED IN THE METHOD, AND TARGET EDITING GUID-RNA TARGET RNA COMPLEX
DE102015012522B3 (de) * 2015-09-26 2016-06-02 Eberhard Karls Universität Tübingen Verfahren und Substanzen zur gerichteten RNA-Editierung
WO2017220751A1 (en) * 2016-06-22 2017-12-28 Proqr Therapeutics Ii B.V. Single-stranded rna-editing oligonucleotides
KR102501980B1 (ko) * 2016-09-01 2023-02-20 프로큐알 테라퓨틱스 Ⅱ 비.브이. 화학적으로 변형된 단일 가닥 rna-편집 올리고뉴클레오타이드
US11274300B2 (en) * 2017-01-19 2022-03-15 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in RNA editing
EP3589751A4 (en) * 2017-03-03 2021-11-17 The Regents of The University of California RNA TARGETING OF MUTATIONS VIA SUPPRESSOR RNA AND DEAMINASES
JP2020511141A (ja) * 2017-03-15 2020-04-16 ザ・ブロード・インスティテュート・インコーポレイテッド 新規Ｃａｓ１３ｂオルソログＣＲＩＳＰＲ酵素及び系

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KR102666695B1 (ko) 2024-05-23
SG11202103666PA (en) 2021-05-28
JP2023078373A (ja) 2023-06-06
CN116218836A (zh) 2023-06-06
IL282191A (en) 2021-05-31
BR112021006844A8 (pt) 2023-03-21
CL2021000880A1 (es) 2021-12-10
CN113631708B (zh) 2022-05-24
CN116042611A (zh) 2023-05-02
DK3864152T5 (da) 2024-08-12
US20210355494A1 (en) 2021-11-18
ES2962434T3 (es) 2024-03-19
CN115651927A (zh) 2023-01-31
EP4306116A3 (en) 2024-04-17
AU2019357450A1 (en) 2021-06-03
CO2021005956A2 (es) 2021-07-30
CA3115864A1 (en) 2020-04-16
KR20210076082A (ko) 2021-06-23
CN113631708A (zh) 2021-11-09
EP3864152A1 (en) 2021-08-18
DK3864152T3 (da) 2023-10-09
PE20211402A1 (es) 2021-08-02
PH12021550805A1 (en) 2021-10-04
EP3864152B1 (en) 2023-08-16
CN115651927B (zh) 2023-06-16
AU2019357450B2 (en) 2023-01-12
JP2021534810A (ja) 2021-12-16
EP3864152A4 (en) 2021-10-13
CR20210243A (es) 2021-10-07
EP4306116A2 (en) 2024-01-17
BR112021006844A2 (pt) 2021-07-20
US20210310026A1 (en) 2021-10-07
ECSP21033637A (es) 2021-08-31
JP7252328B2 (ja) 2023-04-04
WO2020074001A1 (en) 2020-04-16
AU2023202184A1 (en) 2023-05-04
TW202028466A (zh) 2020-08-01

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