MX2021004187A - Métodos y composiciones para editar ácidos ribonucleicos. - Google Patents

Métodos y composiciones para editar ácidos ribonucleicos.

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Publication number
MX2021004187A
MX2021004187A MX2021004187A MX2021004187A MX2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A MX 2021004187 A MX2021004187 A MX 2021004187A
Authority
MX
Mexico
Prior art keywords
methods
compositions
editing
rna
rnas
Prior art date
Application number
MX2021004187A
Other languages
English (en)
Inventor
Chunhui Wang
Wensheng Wei
Liang Qu
Zongyi Yi
Shiyou Zhu
Zhongzheng Cao
Zhuo Zhou
Pengfei Yuan
Original Assignee
Edigene Therapeutics Beijing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Edigene Therapeutics Beijing Inc filed Critical Edigene Therapeutics Beijing Inc
Publication of MX2021004187A publication Critical patent/MX2021004187A/es

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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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Abstract

La presente solicitud proporciona métodos para editar ARN mediante la introducción de un ARN de reclutamiento de desaminasas en una célula hospedera para la desaminación de una adenosina en un ARN objetivo; la presente solicitud proporciona además ARN de reclutamiento de desaminasas usados en los métodos de edición de ARN y composiciones que los comprenden.
MX2021004187A 2018-10-12 2019-10-12 Métodos y composiciones para editar ácidos ribonucleicos. MX2021004187A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018110105 2018-10-12
CN2019082713 2019-04-15
PCT/CN2019/110782 WO2020074001A1 (en) 2018-10-12 2019-10-12 Methods and Compositions for Editing RNAs

Publications (1)

Publication Number Publication Date
MX2021004187A true MX2021004187A (es) 2021-09-08

Family

ID=70163607

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004187A MX2021004187A (es) 2018-10-12 2019-10-12 Métodos y composiciones para editar ácidos ribonucleicos.

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US (2) US20210355494A1 (es)
EP (2) EP3864152B1 (es)
JP (2) JP7252328B2 (es)
CN (4) CN116218836A (es)
AU (2) AU2019357450B2 (es)
BR (1) BR112021006844A8 (es)
CA (1) CA3115864A1 (es)
CL (1) CL2021000880A1 (es)
CO (1) CO2021005956A2 (es)
CR (1) CR20210243A (es)
DK (1) DK3864152T3 (es)
EC (1) ECSP21033637A (es)
ES (1) ES2962434T3 (es)
IL (1) IL282191A (es)
MX (1) MX2021004187A (es)
PE (1) PE20211402A1 (es)
PH (1) PH12021550805A1 (es)
SG (1) SG11202103666PA (es)
TW (1) TW202028466A (es)
WO (1) WO2020074001A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11932856B2 (en) 2017-03-03 2024-03-19 The Regents Of The University Of California RNA targeting of mutations via suppressor tRNAs and deaminases
US20220307020A1 (en) 2019-04-15 2022-09-29 Edigene Inc. Methods and compositions for editing rnas
CR20220063A (es) 2019-07-12 2022-07-22 Univ Beijing Edición de ácido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actúa sobre ácido ribonucleico endógeno (adar) utilizando ácidos ribonucleicos (arn) modificados genéticamente
CN115038789A (zh) 2019-12-02 2022-09-09 塑造治疗公司 治疗性编辑
WO2021136404A1 (zh) 2019-12-30 2021-07-08 博雅辑因（北京）生物科技有限公司 一种治疗Usher综合征的方法和其组合物
JP2023509179A (ja) 2019-12-30 2023-03-07 北京▲輯▼因医▲療▼科技有限公司 Ｌｅａｐｅｒ技術に基づくｍｐｓ ｉｈの治療方法及び組成物
EP4137161A4 (en) * 2020-04-15 2023-10-11 EdiGene Therapeutics (Beijing) Inc. METHOD AND MEDICATION FOR THE TREATMENT OF HURLER SYNDROME
AU2021279027A1 (en) * 2020-05-28 2022-12-08 Korro Bio, Inc. Methods and compositions for the ADAR-mediated editing of SERPINA1
CN113897359A (zh) * 2020-07-06 2022-01-07 博雅辑因（北京）生物科技有限公司 一种改善的rna编辑方法
EP4177345A1 (en) 2020-07-06 2023-05-10 EdiGene Therapeutics (Beijing) Inc. Improved rna editing method
IL278401A (en) 2020-10-29 2022-05-01 Yeda Res & Dev Polynucleotides for editing RNA and a method for using them
EP4240338A1 (en) * 2021-01-04 2023-09-13 The Regents of The University of California <smallcaps/>? ? ?in vivo? ? ? ? ?programmable rna editingvia recruitment of endogenous adars
CN117015605A (zh) * 2021-01-12 2023-11-07 北京大学 使用工程化rna通过利用内源性adar进行靶向rna编辑
US20230123513A1 (en) * 2021-06-15 2023-04-20 Massachusetts Institute Of Technology Deaminase-based rna sensors
WO2023278436A1 (en) * 2021-06-29 2023-01-05 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides
WO2023020574A1 (en) * 2021-08-18 2023-02-23 Peking University Engineered adar-recruiting rnas and methods of use thereof
WO2023060186A1 (en) 2021-10-07 2023-04-13 Hepatx Corporation Methods of tracking donor cells in a recipient
CA3236182A1 (en) * 2021-10-29 2023-05-04 Z. Josh Huang Compositions and systems for rna-programable cell editing and methods of making and using same
WO2023143539A1 (en) * 2022-01-28 2023-08-03 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use thereof
WO2023185231A1 (en) * 2022-04-02 2023-10-05 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use for usher syndrome
WO2024086650A1 (en) * 2022-10-18 2024-04-25 Locanabio, Inc. Compositions and methods comprising programmable snrnas for rna editing

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016094845A2 (en) 2014-12-12 2016-06-16 Woolf Tod M Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
WO2016097212A1 (en) * 2014-12-17 2016-06-23 Proqr Therapeutics Ii B.V. Targeted rna editing
JP6624743B2 (ja) 2015-07-14 2019-12-25 学校法人福岡大学 部位特異的ｒｎａ変異導入方法およびそれに使用する標的編集ガイドｒｎａならびに標的ｒｎａ−標的編集ガイドｒｎａ複合体
DE102015012522B3 (de) * 2015-09-26 2016-06-02 Eberhard Karls Universität Tübingen Verfahren und Substanzen zur gerichteten RNA-Editierung
WO2017220751A1 (en) * 2016-06-22 2017-12-28 Proqr Therapeutics Ii B.V. Single-stranded rna-editing oligonucleotides
PL3507366T3 (pl) * 2016-09-01 2021-05-04 Proqr Therapeutics Ii B.V. Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna
WO2018134301A1 (en) 2017-01-19 2018-07-26 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in rna editing
US11932856B2 (en) 2017-03-03 2024-03-19 The Regents Of The University Of California RNA targeting of mutations via suppressor tRNAs and deaminases
US11739308B2 (en) 2017-03-15 2023-08-29 The Broad Institute, Inc. Cas13b orthologues CRISPR enzymes and systems

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AU2023202184A1 (en) 2023-05-04
CN115651927B (zh) 2023-06-16
CL2021000880A1 (es) 2021-12-10
JP2023078373A (ja) 2023-06-06
EP4306116A2 (en) 2024-01-17
US20210355494A1 (en) 2021-11-18
WO2020074001A1 (en) 2020-04-16
CA3115864A1 (en) 2020-04-16
CN113631708B (zh) 2022-05-24
AU2019357450B2 (en) 2023-01-12
JP2021534810A (ja) 2021-12-16
CO2021005956A2 (es) 2021-07-30
DK3864152T3 (da) 2023-10-09
BR112021006844A8 (pt) 2023-03-21
EP3864152B1 (en) 2023-08-16
BR112021006844A2 (pt) 2021-07-20
PH12021550805A1 (en) 2021-10-04
EP3864152A4 (en) 2021-10-13
PE20211402A1 (es) 2021-08-02
US20210310026A1 (en) 2021-10-07
SG11202103666PA (en) 2021-05-28
CN113631708A (zh) 2021-11-09
KR20210076082A (ko) 2021-06-23
CN116218836A (zh) 2023-06-06
ES2962434T3 (es) 2024-03-19
CN115651927A (zh) 2023-01-31
CR20210243A (es) 2021-10-07
IL282191A (en) 2021-05-31
EP3864152A1 (en) 2021-08-18
AU2019357450A1 (en) 2021-06-03
CN116042611A (zh) 2023-05-02
EP4306116A3 (en) 2024-04-17
TW202028466A (zh) 2020-08-01
JP7252328B2 (ja) 2023-04-04
ECSP21033637A (es) 2021-08-31

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