MX2021001360A - Moléculas de arn que comprenden pares de bases no canónicas. - Google Patents
Moléculas de arn que comprenden pares de bases no canónicas.Info
- Publication number
- MX2021001360A MX2021001360A MX2021001360A MX2021001360A MX2021001360A MX 2021001360 A MX2021001360 A MX 2021001360A MX 2021001360 A MX2021001360 A MX 2021001360A MX 2021001360 A MX2021001360 A MX 2021001360A MX 2021001360 A MX2021001360 A MX 2021001360A
- Authority
- MX
- Mexico
- Prior art keywords
- base pairs
- rna molecules
- canonical base
- canonical
- dsrna
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/60—Isolated nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Mycology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención se refiere a nuevas estructuras de ARN bicatenario (ARNbc) y su uso en el silenciamiento génico.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2018902840A AU2018902840A0 (en) | 2018-08-03 | RNA molecules | |
AU2018902896A AU2018902896A0 (en) | 2018-08-08 | RNA molecules | |
PCT/AU2018/051015 WO2019051563A1 (en) | 2017-09-15 | 2018-09-17 | RNA MOLECULES |
AU2019900941A AU2019900941A0 (en) | 2019-03-20 | RNA molecules | |
PCT/AU2019/050814 WO2020024019A1 (en) | 2018-08-03 | 2019-08-02 | Rna molecules comprising non-canonical base pairs |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021001360A true MX2021001360A (es) | 2021-07-16 |
Family
ID=69230474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021001360A MX2021001360A (es) | 2018-08-03 | 2019-08-02 | Moléculas de arn que comprenden pares de bases no canónicas. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20210269800A1 (es) |
EP (1) | EP3830268A4 (es) |
JP (1) | JP2021533812A (es) |
KR (1) | KR20210054518A (es) |
CN (1) | CN112888785A (es) |
AU (1) | AU2019313162B2 (es) |
BR (1) | BR112021001978A2 (es) |
CA (1) | CA3108536A1 (es) |
IL (1) | IL280562A (es) |
MX (1) | MX2021001360A (es) |
PH (1) | PH12021500009A1 (es) |
SG (1) | SG11202101059WA (es) |
WO (1) | WO2020024019A1 (es) |
ZA (1) | ZA202101256B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2022001439A (es) * | 2019-08-02 | 2022-05-06 | Commw Scient Ind Res Org | Moléculas de arn para modular el florecimiento en plantas. |
WO2021174259A1 (en) * | 2020-02-28 | 2021-09-02 | The University Of Chicago | Methods and compositions comprising trans-acting translational activators |
CN111979210A (zh) * | 2020-08-31 | 2020-11-24 | 中国农业大学 | 辣椒疫霉纤维素合酶蛋白及其编码基因与应用 |
CN115011609B (zh) * | 2022-06-06 | 2024-03-19 | 江苏大学 | BnaFANCM基因、应用及获得油菜雄性不育突变体的方法 |
CN116478262B (zh) * | 2022-09-28 | 2024-03-22 | 西南大学 | RACK1在抗家蚕核型多角体病毒BmNPV中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
CN101370940A (zh) * | 2006-01-12 | 2009-02-18 | 德福根有限公司 | 作为昆虫防治剂的dsRNA |
ES2546394T3 (es) * | 2007-01-29 | 2015-09-23 | University Of The Witwatersrand, Johannesburg | Uso de duplos horquillados de ARN bicatenarios en el silenciamiento genético |
US8841437B2 (en) * | 2008-06-20 | 2014-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Precursor miRNA loop-modulated target regulation |
GB0810912D0 (en) * | 2008-06-13 | 2008-07-23 | Inst Animal Health Ltd | Vector |
AU2011223820B2 (en) * | 2010-03-01 | 2016-01-14 | The Children's Hospital Of Philadelphia | Nucleic acids for targeting multiple regions of the HCV genome |
US20130245102A1 (en) * | 2010-10-12 | 2013-09-19 | Research Foundation Of The City University Of New York | Novel dna templates for small rna production in mammalian cells |
CN102352360B (zh) * | 2011-11-11 | 2012-10-10 | 南开大学 | 抑制hiv-1的双长发卡结构rna表达原件的构建及功能检测 |
WO2016100333A1 (en) * | 2014-12-15 | 2016-06-23 | Syngenta Participations Ag | Pesticidal microrna carriers and use thereof |
-
2019
- 2019-08-02 US US17/265,713 patent/US20210269800A1/en active Pending
- 2019-08-02 BR BR112021001978-2A patent/BR112021001978A2/pt unknown
- 2019-08-02 WO PCT/AU2019/050814 patent/WO2020024019A1/en active Search and Examination
- 2019-08-02 CA CA3108536A patent/CA3108536A1/en active Pending
- 2019-08-02 CN CN201980065254.2A patent/CN112888785A/zh active Pending
- 2019-08-02 SG SG11202101059WA patent/SG11202101059WA/en unknown
- 2019-08-02 EP EP19844044.8A patent/EP3830268A4/en active Pending
- 2019-08-02 KR KR1020217006457A patent/KR20210054518A/ko active Search and Examination
- 2019-08-02 JP JP2021529494A patent/JP2021533812A/ja active Pending
- 2019-08-02 MX MX2021001360A patent/MX2021001360A/es unknown
- 2019-08-02 AU AU2019313162A patent/AU2019313162B2/en active Active
-
2021
- 2021-02-01 IL IL280562A patent/IL280562A/en unknown
- 2021-02-02 PH PH12021500009A patent/PH12021500009A1/en unknown
- 2021-02-24 ZA ZA2021/01256A patent/ZA202101256B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3108536A1 (en) | 2020-02-06 |
PH12021500009A1 (en) | 2021-09-13 |
EP3830268A4 (en) | 2023-12-13 |
KR20210054518A (ko) | 2021-05-13 |
EP3830268A1 (en) | 2021-06-09 |
AU2019313162B2 (en) | 2024-02-22 |
BR112021001978A2 (pt) | 2021-05-04 |
IL280562A (en) | 2021-03-25 |
ZA202101256B (en) | 2022-09-28 |
US20210269800A1 (en) | 2021-09-02 |
WO2020024019A1 (en) | 2020-02-06 |
JP2021533812A (ja) | 2021-12-09 |
CN112888785A (zh) | 2021-06-01 |
SG11202101059WA (en) | 2021-02-25 |
AU2019313162A1 (en) | 2021-03-18 |
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