MX2021000456A - Compuesto triciclico fusionado como inhibidor dual pde3/pde4. - Google Patents
Compuesto triciclico fusionado como inhibidor dual pde3/pde4.Info
- Publication number
- MX2021000456A MX2021000456A MX2021000456A MX2021000456A MX2021000456A MX 2021000456 A MX2021000456 A MX 2021000456A MX 2021000456 A MX2021000456 A MX 2021000456A MX 2021000456 A MX2021000456 A MX 2021000456A MX 2021000456 A MX2021000456 A MX 2021000456A
- Authority
- MX
- Mexico
- Prior art keywords
- pde3
- cyclic compound
- pde4
- dual inhibitor
- fused tri
- Prior art date
Links
- 101100135868 Dictyostelium discoideum pde3 gene Proteins 0.000 title abstract 3
- 229940125436 dual inhibitor Drugs 0.000 title abstract 2
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 2
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se proporciona un compuesto tricíclico fusionado como inhibidor dual de PDE3/PDE4, y un uso del mismo en la preparación de fármacos para enfermedades asociadas a PDE3/PDE4, particularmente en funciones medicinales tales como enfermedad pulmonar obstructiva crónica (EPOC). Se proporcionan específicamente un compuesto de fórmula (|) y una sal farmacéuticamente aceptable del mismo. (Ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810772374 | 2018-07-13 | ||
PCT/CN2019/095826 WO2020011254A1 (zh) | 2018-07-13 | 2019-07-12 | 作为pde3/pde4双重抑制剂的三并环类化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021000456A true MX2021000456A (es) | 2021-07-21 |
Family
ID=69143182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000456A MX2021000456A (es) | 2018-07-13 | 2019-07-12 | Compuesto triciclico fusionado como inhibidor dual pde3/pde4. |
Country Status (10)
Country | Link |
---|---|
US (1) | US11993596B2 (es) |
EP (1) | EP3822272A4 (es) |
JP (1) | JP7491896B2 (es) |
KR (1) | KR20210031727A (es) |
CN (2) | CN112368281B (es) |
AU (2) | AU2019302610B2 (es) |
CA (1) | CA3106052A1 (es) |
IL (1) | IL280075B1 (es) |
MX (1) | MX2021000456A (es) |
WO (1) | WO2020011254A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230060174A1 (en) * | 2020-01-15 | 2023-03-02 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound |
JP2023512471A (ja) * | 2020-01-15 | 2023-03-27 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Pde3/pde4二重阻害剤の結晶及びその使用 |
CA3211820A1 (en) | 2021-04-29 | 2022-11-03 | Zhiya LI | Isoquinolone compound and use thereof |
WO2023109802A1 (zh) * | 2021-12-14 | 2023-06-22 | 海思科医药集团股份有限公司 | 三环稠杂环类pde3/4双重抑制及其用途 |
WO2023138676A1 (zh) * | 2022-01-21 | 2023-07-27 | 四川海思科制药有限公司 | 三环稠杂环类pde3/4双重抑制及其用途 |
WO2024088402A1 (zh) * | 2022-10-28 | 2024-05-02 | 江苏恒瑞医药股份有限公司 | 一种异喹啉酮类化合物的晶型及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ185900A (en) | 1976-12-10 | 1981-04-24 | Hoechst Ag | Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines |
FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
ZW6284A1 (en) * | 1983-05-05 | 1985-10-30 | Hoffmann La Roche | Novel pyrimidone derivatives |
EP1022868B1 (en) | 1998-07-22 | 2004-11-24 | Mitsubishi Denki Kabushiki Kaisha | Mobile communication system and mobile communication method |
DE60005493T2 (de) * | 1999-03-31 | 2004-07-01 | Vernalis Ltd., Wokingham | Pyrimido[6,1-a]isochinolinonderivate |
PL2603509T3 (pl) | 2010-08-09 | 2014-11-28 | Verona Pharma Plc | Krystaliczna postać związku pirymidio[6,1-a]izochinolin-4-onowego |
-
2019
- 2019-07-12 AU AU2019302610A patent/AU2019302610B2/en active Active
- 2019-07-12 EP EP19834834.4A patent/EP3822272A4/en active Pending
- 2019-07-12 US US17/259,089 patent/US11993596B2/en active Active
- 2019-07-12 MX MX2021000456A patent/MX2021000456A/es unknown
- 2019-07-12 CN CN201980045308.9A patent/CN112368281B/zh active Active
- 2019-07-12 JP JP2021501020A patent/JP7491896B2/ja active Active
- 2019-07-12 IL IL280075A patent/IL280075B1/en unknown
- 2019-07-12 CA CA3106052A patent/CA3106052A1/en active Pending
- 2019-07-12 WO PCT/CN2019/095826 patent/WO2020011254A1/zh unknown
- 2019-07-12 CN CN202210301047.6A patent/CN114644630A/zh active Pending
- 2019-07-12 KR KR1020217004102A patent/KR20210031727A/ko unknown
-
2024
- 2024-02-21 AU AU2024201135A patent/AU2024201135A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP7491896B2 (ja) | 2024-05-28 |
CN112368281B (zh) | 2022-02-18 |
WO2020011254A1 (zh) | 2020-01-16 |
AU2024201135A1 (en) | 2024-03-14 |
EP3822272A4 (en) | 2022-04-06 |
CA3106052A1 (en) | 2020-01-16 |
IL280075B1 (en) | 2024-02-01 |
US11993596B2 (en) | 2024-05-28 |
CN114644630A (zh) | 2022-06-21 |
KR20210031727A (ko) | 2021-03-22 |
AU2019302610B2 (en) | 2023-11-23 |
JP2021532088A (ja) | 2021-11-25 |
IL280075A (en) | 2021-03-01 |
US20210323960A1 (en) | 2021-10-21 |
EP3822272A1 (en) | 2021-05-19 |
AU2019302610A1 (en) | 2021-03-04 |
CN112368281A (zh) | 2021-02-12 |
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