MX2020014265A - Anticuerpo variante que se une a cd38. - Google Patents
Anticuerpo variante que se une a cd38.Info
- Publication number
- MX2020014265A MX2020014265A MX2020014265A MX2020014265A MX2020014265A MX 2020014265 A MX2020014265 A MX 2020014265A MX 2020014265 A MX2020014265 A MX 2020014265A MX 2020014265 A MX2020014265 A MX 2020014265A MX 2020014265 A MX2020014265 A MX 2020014265A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- present disclosure
- binds
- disclosure provides
- variant antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente divulgación proporciona un anticuerpo anti-CD38 de clase IgG que tiene una capacidad mejorada para prepararse con mayores rendimientos en comparación con el anticuerpo precursor que tiene la secuencia precursora de tipo silvestre. La presente divulgación proporciona una cadena ligera del anticuerpo mutada que reduce la heterogeneidad de escisión para producción mejorada de una población homogénea de cadenas ligeras de anticuerpo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862687695P | 2018-06-20 | 2018-06-20 | |
PCT/US2019/021417 WO2019245616A1 (en) | 2018-06-20 | 2019-03-08 | Variant antibody that binds cd38 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020014265A true MX2020014265A (es) | 2021-05-27 |
Family
ID=68984328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020014265A MX2020014265A (es) | 2018-06-20 | 2019-03-08 | Anticuerpo variante que se une a cd38. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210130484A1 (es) |
EP (1) | EP3810655A4 (es) |
JP (2) | JP2021528067A (es) |
KR (1) | KR20210022684A (es) |
CN (1) | CN112313250A (es) |
AU (1) | AU2019288972A1 (es) |
CA (1) | CA3103114A1 (es) |
MX (1) | MX2020014265A (es) |
SG (1) | SG11202012133TA (es) |
WO (1) | WO2019245616A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114524877A (zh) * | 2019-03-29 | 2022-05-24 | 索伦托药业有限公司 | 结合cd38的经工程改造的变异抗体 |
AU2020396548A1 (en) | 2019-12-05 | 2022-07-14 | Sorrento Therapeutics, Inc. | Compositions and methods comprising an anti-CD47 antibody in combination with a tumor targeting antibody |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI428444B (zh) * | 2005-10-12 | 2014-03-01 | Morphosys Ag | 由全長人類HuCAL GOLD-衍生之對人類CD38有特異性之治療抗體之產生及鑑定 |
AU2012212297B2 (en) * | 2011-01-31 | 2016-03-17 | Northwestern University | Injectable thermoresponsive polyelectrolytes |
WO2013138431A1 (en) * | 2012-03-15 | 2013-09-19 | The Penn State Research Foundation, The Pennsylvania State University | Methods for predicting and treating necrotizing enterocolitis in neonates |
WO2016164656A1 (en) * | 2015-04-08 | 2016-10-13 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd38 |
EP3368561A1 (en) * | 2015-10-30 | 2018-09-05 | Medimmune Limited | Prevention of n-terminal truncation in igg light chains |
KR20200017519A (ko) * | 2017-06-20 | 2020-02-18 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Cd38 항체 약물 접합체 |
JP2021501587A (ja) * | 2017-11-03 | 2021-01-21 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | Cd38指向性キメラ抗原受容体構築物 |
SG11202008568WA (en) * | 2018-03-09 | 2020-10-29 | Sorrento Therapeutics Inc | Dimeric antigen receptors (dar) |
CN114524877A (zh) * | 2019-03-29 | 2022-05-24 | 索伦托药业有限公司 | 结合cd38的经工程改造的变异抗体 |
-
2019
- 2019-03-08 WO PCT/US2019/021417 patent/WO2019245616A1/en unknown
- 2019-03-08 EP EP19822721.7A patent/EP3810655A4/en active Pending
- 2019-03-08 CN CN201980041123.0A patent/CN112313250A/zh active Pending
- 2019-03-08 MX MX2020014265A patent/MX2020014265A/es unknown
- 2019-03-08 SG SG11202012133TA patent/SG11202012133TA/en unknown
- 2019-03-08 KR KR1020217001742A patent/KR20210022684A/ko active Search and Examination
- 2019-03-08 JP JP2020570561A patent/JP2021528067A/ja active Pending
- 2019-03-08 AU AU2019288972A patent/AU2019288972A1/en active Pending
- 2019-03-08 CA CA3103114A patent/CA3103114A1/en active Pending
-
2020
- 2020-12-18 US US17/127,766 patent/US20210130484A1/en active Pending
-
2024
- 2024-02-05 JP JP2024015704A patent/JP2024036508A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20210022684A (ko) | 2021-03-03 |
SG11202012133TA (en) | 2021-01-28 |
CA3103114A1 (en) | 2019-12-26 |
EP3810655A4 (en) | 2022-03-16 |
JP2024036508A (ja) | 2024-03-15 |
CN112313250A (zh) | 2021-02-02 |
WO2019245616A9 (en) | 2020-12-24 |
JP2021528067A (ja) | 2021-10-21 |
WO2019245616A1 (en) | 2019-12-26 |
EP3810655A1 (en) | 2021-04-28 |
US20210130484A1 (en) | 2021-05-06 |
AU2019288972A1 (en) | 2021-02-04 |
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