MX2020013719A - Nuevos compuestos heterociclicos como inhibidores de monoacilglicerol lipasa. - Google Patents
Nuevos compuestos heterociclicos como inhibidores de monoacilglicerol lipasa.Info
- Publication number
- MX2020013719A MX2020013719A MX2020013719A MX2020013719A MX2020013719A MX 2020013719 A MX2020013719 A MX 2020013719A MX 2020013719 A MX2020013719 A MX 2020013719A MX 2020013719 A MX2020013719 A MX 2020013719A MX 2020013719 A MX2020013719 A MX 2020013719A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- heterocyclic compounds
- new heterocyclic
- monoacylglycerol lipase
- lipase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención proporciona nuevos compuestos heterocíclicos que tienen la fórmula general (I) (ver Fórmula) en donde A, L, X, m, n, R1 y R2 son como se describen en el presente documento, composiciones que incluyen los compuestos, procesos de fabricación de los compuestos, métodos de uso de los compuestos y métodos para determinar la actividad inhibidora de monoacilglicerol lipasa (MAGL) de los compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18188679 | 2018-08-13 | ||
| PCT/EP2019/071522 WO2020035425A1 (en) | 2018-08-13 | 2019-08-12 | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020013719A true MX2020013719A (es) | 2021-03-02 |
Family
ID=63244466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020013719A MX2020013719A (es) | 2018-08-13 | 2019-08-12 | Nuevos compuestos heterociclicos como inhibidores de monoacilglicerol lipasa. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20210277020A1 (es) |
| EP (1) | EP3837264A1 (es) |
| JP (1) | JP2021533093A (es) |
| KR (1) | KR20210044217A (es) |
| CN (1) | CN112469724A (es) |
| AR (1) | AR115949A1 (es) |
| AU (1) | AU2019322161A1 (es) |
| BR (1) | BR112020025642A2 (es) |
| CA (1) | CA3098272A1 (es) |
| CL (1) | CL2021000361A1 (es) |
| CR (1) | CR20210056A (es) |
| IL (1) | IL280762A (es) |
| MA (1) | MA53220A (es) |
| MX (1) | MX2020013719A (es) |
| PE (1) | PE20211380A1 (es) |
| PH (1) | PH12021500015A1 (es) |
| SG (1) | SG11202012222TA (es) |
| TW (1) | TWI814882B (es) |
| WO (1) | WO2020035425A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
| TW201936602A (zh) | 2017-11-28 | 2019-09-16 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
| EP3737680A1 (en) | 2018-01-08 | 2020-11-18 | F. Hoffmann-La Roche AG | Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors |
| WO2019168847A1 (en) | 2018-02-27 | 2019-09-06 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| KR20210049090A (ko) | 2018-07-05 | 2021-05-04 | 인사이트 코포레이션 | A2a/a2b 억제제로서 융합된 피라진 유도체 |
| FI3837263T3 (fi) | 2018-08-13 | 2024-09-03 | Hoffmann La Roche | Uusia heterosyklisiä yhdisteitä monoasyyliglyserolilipaasin estäjinä |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US20210094971A1 (en) * | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
| WO2021048241A1 (en) * | 2019-09-12 | 2021-03-18 | F. Hoffmann-La Roche Ag | Radiolabeled compounds |
| EP4028403B1 (en) | 2019-09-12 | 2023-11-22 | F. Hoffmann-La Roche AG | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| WO2021058416A1 (en) * | 2019-09-23 | 2021-04-01 | F. Hoffmann-La Roche Ag | Heterocyclic compounds |
| WO2021058445A1 (en) * | 2019-09-24 | 2021-04-01 | F. Hoffmann-La Roche Ag | New heterocyclic monoacylglycerol lipase (magl) inhibitors |
| MX2022002831A (es) * | 2019-09-24 | 2022-04-06 | Hoffmann La Roche | Compuestos heterociclicos. |
| IL299664A (en) | 2020-09-03 | 2023-03-01 | Hoffmann La Roche | Heterocyclic compounds |
| WO2024031088A1 (en) | 2022-08-05 | 2024-02-08 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579495B2 (en) | 2003-12-19 | 2009-08-25 | Momentive Performance Materials Inc. | Active-releasing cyclic siloxanes |
| FR2915197B1 (fr) * | 2007-04-18 | 2009-06-12 | Sanofi Aventis Sa | Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique. |
| TW200942537A (en) * | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| RU2538204C2 (ru) | 2009-09-10 | 2015-01-10 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы jak |
| WO2011059118A1 (ko) | 2009-11-10 | 2011-05-19 | Kim Hyun Jeen | 후각인지능력 검사 시스템 |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| JP2014533747A (ja) * | 2011-11-30 | 2014-12-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ３，７−二置換オクタヒドロ−２Ｈ−ピリド［４，３−ｅ］［１，３］オキサジン−２−オン抗生物質 |
| JP6653319B2 (ja) * | 2015-03-30 | 2020-02-26 | 武田薬品工業株式会社 | 複素環化合物 |
| EA033680B1 (ru) | 2015-05-21 | 2019-11-15 | Glaxosmithkline Ip Dev Ltd | Производные бензоимидазола в качестве ингибиторов pad4 |
| MY194647A (en) * | 2016-03-31 | 2022-12-09 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| EP3438109B1 (en) * | 2016-03-31 | 2021-08-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
-
2019
- 2019-08-12 CR CR20210056A patent/CR20210056A/es unknown
- 2019-08-12 AU AU2019322161A patent/AU2019322161A1/en active Pending
- 2019-08-12 EP EP19755856.2A patent/EP3837264A1/en not_active Withdrawn
- 2019-08-12 PE PE2020002021A patent/PE20211380A1/es unknown
- 2019-08-12 CN CN201980048654.2A patent/CN112469724A/zh active Pending
- 2019-08-12 BR BR112020025642-0A patent/BR112020025642A2/pt unknown
- 2019-08-12 CA CA3098272A patent/CA3098272A1/en active Pending
- 2019-08-12 MX MX2020013719A patent/MX2020013719A/es unknown
- 2019-08-12 JP JP2021503816A patent/JP2021533093A/ja active Pending
- 2019-08-12 SG SG11202012222TA patent/SG11202012222TA/en unknown
- 2019-08-12 MA MA053220A patent/MA53220A/fr unknown
- 2019-08-12 KR KR1020217004224A patent/KR20210044217A/ko not_active Application Discontinuation
- 2019-08-12 WO PCT/EP2019/071522 patent/WO2020035425A1/en active Application Filing
- 2019-08-13 AR ARP190102302A patent/AR115949A1/es unknown
- 2019-08-13 TW TW108128684A patent/TWI814882B/zh active
-
2021
- 2021-02-09 IL IL280762A patent/IL280762A/en unknown
- 2021-02-10 CL CL2021000361A patent/CL2021000361A1/es unknown
- 2021-02-11 PH PH12021500015A patent/PH12021500015A1/en unknown
- 2021-02-11 US US17/174,000 patent/US20210277020A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021000361A1 (es) | 2021-07-09 |
| PH12021500015A1 (en) | 2021-09-13 |
| CR20210056A (es) | 2021-03-02 |
| EP3837264A1 (en) | 2021-06-23 |
| PE20211380A1 (es) | 2021-07-27 |
| TW202035421A (zh) | 2020-10-01 |
| MA53220A (fr) | 2021-11-17 |
| CN112469724A (zh) | 2021-03-09 |
| US20210277020A1 (en) | 2021-09-09 |
| IL280762A (en) | 2021-04-29 |
| JP2021533093A (ja) | 2021-12-02 |
| AU2019322161A1 (en) | 2020-11-12 |
| BR112020025642A2 (pt) | 2021-03-23 |
| CA3098272A1 (en) | 2020-02-20 |
| TWI814882B (zh) | 2023-09-11 |
| KR20210044217A (ko) | 2021-04-22 |
| WO2020035425A1 (en) | 2020-02-20 |
| SG11202012222TA (en) | 2021-01-28 |
| AR115949A1 (es) | 2021-03-17 |
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