MX2020012305A - Sintesis de tipifarnib. - Google Patents
Sintesis de tipifarnib.Info
- Publication number
- MX2020012305A MX2020012305A MX2020012305A MX2020012305A MX2020012305A MX 2020012305 A MX2020012305 A MX 2020012305A MX 2020012305 A MX2020012305 A MX 2020012305A MX 2020012305 A MX2020012305 A MX 2020012305A MX 2020012305 A MX2020012305 A MX 2020012305A
- Authority
- MX
- Mexico
- Prior art keywords
- tipifarnib
- synthesis
- chlorophenyl
- methyl
- quinolinone
- Prior art date
Links
- PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 title abstract 2
- 229950009158 tipifarnib Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 1 -methyl- 1H-imidazol-5-yl Chemical group 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862673693P | 2018-05-18 | 2018-05-18 | |
| PCT/US2019/032765 WO2019222565A1 (en) | 2018-05-18 | 2019-05-17 | Synthesis of tipifarnib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020012305A true MX2020012305A (es) | 2021-03-25 |
Family
ID=66770583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012305A MX2020012305A (es) | 2018-05-18 | 2019-05-17 | Sintesis de tipifarnib. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11542244B2 (enExample) |
| EP (1) | EP3793966A1 (enExample) |
| JP (1) | JP2021526513A (enExample) |
| KR (1) | KR20210039987A (enExample) |
| CN (1) | CN112424149B (enExample) |
| AU (1) | AU2019270163A1 (enExample) |
| BR (1) | BR112020023559A2 (enExample) |
| CA (1) | CA3100706A1 (enExample) |
| EA (1) | EA202092787A1 (enExample) |
| MX (1) | MX2020012305A (enExample) |
| PH (1) | PH12020551956A1 (enExample) |
| SG (1) | SG11202011378WA (enExample) |
| WO (1) | WO2019222565A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102839264B1 (ko) | 2023-03-07 | 2025-07-29 | 단국대학교 천안캠퍼스 산학협력단 | 티피파르닙을 유효성분으로 포함하는 근감소증 예방 또는 치료용 약학 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE214695T1 (de) * | 1994-09-23 | 2002-04-15 | Darwin Discovery Ltd | Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen |
| AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
| EE03484B1 (et) | 1995-12-08 | 2001-08-15 | Janssen Pharmaceutica N.V. | Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine |
| EA006770B1 (ru) | 2001-03-12 | 2006-04-28 | Янссен Фармацевтика Н.В. | Способ получения соединений имидазола |
| EP1758885B1 (en) * | 2004-05-03 | 2008-06-18 | Janssen Pharmaceutica N.V. | Diastereoselective addition of lithiated n-methylimidazole on sulfinimines |
| US7572916B2 (en) * | 2004-05-03 | 2009-08-11 | Janssen Pharmaceutica Nv | Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline |
| CN100567292C (zh) * | 2004-05-03 | 2009-12-09 | 詹森药业有限公司 | 制备咪唑化合物的非对映选择性合成方法 |
| WO2016078758A1 (en) * | 2014-11-21 | 2016-05-26 | Merck Patent Gmbh | Method for the production of praziquantel |
| CN104876856B (zh) | 2015-05-05 | 2017-11-21 | 河北凯力昂生物科技有限公司 | 一种拆分法制备(r)‑(+)‑3‑氨基哌啶二盐酸盐的方法 |
-
2019
- 2019-05-17 EP EP19728818.6A patent/EP3793966A1/en not_active Withdrawn
- 2019-05-17 JP JP2020564572A patent/JP2021526513A/ja not_active Withdrawn
- 2019-05-17 MX MX2020012305A patent/MX2020012305A/es unknown
- 2019-05-17 AU AU2019270163A patent/AU2019270163A1/en not_active Abandoned
- 2019-05-17 CA CA3100706A patent/CA3100706A1/en active Pending
- 2019-05-17 KR KR1020207036324A patent/KR20210039987A/ko not_active Withdrawn
- 2019-05-17 SG SG11202011378WA patent/SG11202011378WA/en unknown
- 2019-05-17 CN CN201980047803.3A patent/CN112424149B/zh active Active
- 2019-05-17 US US17/056,745 patent/US11542244B2/en active Active
- 2019-05-17 BR BR112020023559-8A patent/BR112020023559A2/pt not_active Application Discontinuation
- 2019-05-17 WO PCT/US2019/032765 patent/WO2019222565A1/en not_active Ceased
- 2019-05-17 EA EA202092787A patent/EA202092787A1/ru unknown
-
2020
- 2020-11-16 PH PH12020551956A patent/PH12020551956A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019222565A1 (en) | 2019-11-21 |
| US11542244B2 (en) | 2023-01-03 |
| EA202092787A1 (ru) | 2021-02-09 |
| AU2019270163A1 (en) | 2020-12-03 |
| CA3100706A1 (en) | 2019-11-21 |
| BR112020023559A2 (pt) | 2021-02-09 |
| SG11202011378WA (en) | 2020-12-30 |
| CN112424149B (zh) | 2023-06-23 |
| EP3793966A1 (en) | 2021-03-24 |
| PH12020551956A1 (en) | 2021-08-16 |
| JP2021526513A (ja) | 2021-10-07 |
| CN112424149A (zh) | 2021-02-26 |
| US20210246114A1 (en) | 2021-08-12 |
| KR20210039987A (ko) | 2021-04-12 |
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