MX2020011724A - Nanoparticula que comprende un poliester biorresorbible, un polimero hidrofilo y un peptido acilado derivado de lactoferrina humana. - Google Patents

Nanoparticula que comprende un poliester biorresorbible, un polimero hidrofilo y un peptido acilado derivado de lactoferrina humana.

Info

Publication number
MX2020011724A
MX2020011724A MX2020011724A MX2020011724A MX2020011724A MX 2020011724 A MX2020011724 A MX 2020011724A MX 2020011724 A MX2020011724 A MX 2020011724A MX 2020011724 A MX2020011724 A MX 2020011724A MX 2020011724 A MX2020011724 A MX 2020011724A
Authority
MX
Mexico
Prior art keywords
bio
derived peptide
human lactoferrin
hydrophilic polymer
nanoparticle
Prior art date
Application number
MX2020011724A
Other languages
English (en)
Inventor
Roland Brock
Rike Nabbefeld
Silko Grimm
Anne Benedikt
Andrea Engel
Van Asbeck Alexander Henrik Baron
Jürgen Dieker
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of MX2020011724A publication Critical patent/MX2020011724A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La invención se refiere a una nanopartícula que comprende un núcleo, que comprende un poliéster biorresorbible y un polímero hidrófilo, en la que el polímero hidrófilo es una parte del poliéster biorresorbible o un polímero independiente y, sobre el núcleo, un péptido acilado derivado de la lactoferrina humana, en dla que el péptido acilado derivado de lactoferrina humana es un péptido que tiene la secuencia de aminoácidos SEQ ID No.1: KCFQWQRNMRKVRGPPVSCIKR o una secuencia de aminoácidos, que no difiere en más de 8 posiciones de aminoácido de la secuencia 10 SEQ.ID.No.1 y en la que el extremo N del péptido derivado de lactoferrina humana se ha acilado con un grupo monoacilo C16.
MX2020011724A 2018-05-08 2019-04-24 Nanoparticula que comprende un poliester biorresorbible, un polimero hidrofilo y un peptido acilado derivado de lactoferrina humana. MX2020011724A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18171195 2018-05-08
PCT/EP2019/060410 WO2019214939A1 (en) 2018-05-08 2019-04-24 Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide

Publications (1)

Publication Number Publication Date
MX2020011724A true MX2020011724A (es) 2021-01-08

Family

ID=62142979

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020011724A MX2020011724A (es) 2018-05-08 2019-04-24 Nanoparticula que comprende un poliester biorresorbible, un polimero hidrofilo y un peptido acilado derivado de lactoferrina humana.

Country Status (14)

Country Link
US (1) US11052053B2 (es)
EP (1) EP3790534B1 (es)
JP (1) JP2021523137A (es)
KR (1) KR20210008496A (es)
CN (1) CN112469397B (es)
BR (1) BR112020022353A2 (es)
CA (1) CA3099459A1 (es)
ES (1) ES2964393T3 (es)
HU (1) HUE063939T2 (es)
IL (1) IL278469B2 (es)
MX (1) MX2020011724A (es)
PL (1) PL3790534T3 (es)
SI (1) SI3790534T1 (es)
WO (1) WO2019214939A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL294641A (en) 2019-10-31 2022-09-01 Evonik Operations Gmbh A process for preparing nanoparticles or microparticles containing a carrier polymer and one or more biologically active components
CN111393227B (zh) * 2020-04-08 2022-07-08 黑龙江八一农垦大学 一种种衣剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3937272A1 (de) 1989-11-09 1991-05-16 Boehringer Ingelheim Kg Neue copolymere aus trimethylencarbonat und optisch inaktiven laktiden
DE10200738A1 (de) 2002-01-11 2003-08-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von resorbierbaren Polyestern durch Massepolymerisation
US6706854B2 (en) 2002-01-11 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing reabsorbable polyesters by mass polymerization
DE102005033101A1 (de) 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbierbare Polyetherester und ihre Verwendung zur Herstellung von medizinischen Implantaten
DE102005051366A1 (de) 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
MX2008008548A (es) 2005-12-30 2008-09-10 Evonik Roehm Gmbh Peptidos utiles como petidos penetradores de celulas.
DE102007020951A1 (de) 2007-05-04 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters
EP2643344B1 (en) 2010-11-26 2017-03-22 Evonik Röhm GmbH Human lactoferrin derived peptide for use as an antigen masking agent
JP6038167B2 (ja) * 2011-10-31 2016-12-07 ケーン バイオテク インコーポレーテッド 口腔疾患を予防及び治療する組成物及び方法
US9770419B2 (en) * 2012-08-01 2017-09-26 Shaker A. Mousa Methods and compositions of camel derived products
CA2950339C (en) 2014-05-28 2022-03-29 Evonik Rohm Gmbh Coated calcium phosphate nanoparticles comprising a cationic polymer layer

Also Published As

Publication number Publication date
HUE063939T2 (hu) 2024-02-28
KR20210008496A (ko) 2021-01-22
ES2964393T3 (es) 2024-04-05
CN112469397B (zh) 2022-12-02
EP3790534A1 (en) 2021-03-17
US11052053B2 (en) 2021-07-06
IL278469A (es) 2021-01-31
IL278469B1 (en) 2023-10-01
IL278469B2 (en) 2024-02-01
PL3790534T3 (pl) 2024-02-19
JP2021523137A (ja) 2021-09-02
CN112469397A (zh) 2021-03-09
CA3099459A1 (en) 2019-11-14
US20210137847A1 (en) 2021-05-13
BR112020022353A2 (pt) 2021-02-02
WO2019214939A1 (en) 2019-11-14
EP3790534B1 (en) 2023-08-30
SI3790534T1 (sl) 2023-12-29

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