MX2020010926A - Animales resistentes a patogenos que tienen genes aminopeptidasa n (anpep) modificados. - Google Patents

Animales resistentes a patogenos que tienen genes aminopeptidasa n (anpep) modificados.

Info

Publication number
MX2020010926A
MX2020010926A MX2020010926A MX2020010926A MX2020010926A MX 2020010926 A MX2020010926 A MX 2020010926A MX 2020010926 A MX2020010926 A MX 2020010926A MX 2020010926 A MX2020010926 A MX 2020010926A MX 2020010926 A MX2020010926 A MX 2020010926A
Authority
MX
Mexico
Prior art keywords
animals
anpep
offspring
pathogen
protein
Prior art date
Application number
MX2020010926A
Other languages
English (en)
Inventor
Randall S Prather
Kevin D Wells
Kristin M Whitworth
Original Assignee
Univ Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri filed Critical Univ Missouri
Publication of MX2020010926A publication Critical patent/MX2020010926A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11—Aminopeptidases (3.4.11)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se proporcionan animales de ganado y crías de estos que comprenden al menos una secuencia cromosómica modificada en un gen que codifica una proteína aminopeptidasa N (ANPEP). También se proporcionan células animales que contienen tales secuencias cromosómicas modificadas. Los animales, las crías y las células tienen una mayor resistencia a los patógenos, incluido el virus de la gastroenteritis transmisible (TGEV) y el coronavirus respiratorio porcino (PRCV). Los animales, las crías y las células pueden comprender opcionalmente además al menos una secuencia cromosómica modificada en un gen que codifica una proteína CD163 y/o una proteína SIGLEC1. También se proporcionan métodos para producir animales no humanos resistentes a patógenos o linajes de animales no humanos.
MX2020010926A 2018-04-27 2019-04-26 Animales resistentes a patogenos que tienen genes aminopeptidasa n (anpep) modificados. MX2020010926A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862663495P 2018-04-27 2018-04-27
PCT/US2019/029356 WO2019210175A1 (en) 2018-04-27 2019-04-26 Pathogen-resistant animals having modified aminopeptidase n (anpep) genes

Publications (1)

Publication Number Publication Date
MX2020010926A true MX2020010926A (es) 2021-01-08

Family

ID=68295755

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010926A MX2020010926A (es) 2018-04-27 2019-04-26 Animales resistentes a patogenos que tienen genes aminopeptidasa n (anpep) modificados.

Country Status (10)

Country Link
US (1) US20200236914A1 (es)
JP (1) JP2021521844A (es)
KR (1) KR20210005661A (es)
CN (1) CN112313330A (es)
AU (1) AU2019257776A1 (es)
BR (1) BR112020021476A2 (es)
CA (1) CA3096283A1 (es)
MX (1) MX2020010926A (es)
PH (1) PH12020551629A1 (es)
WO (1) WO2019210175A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112063620A (zh) * 2020-06-16 2020-12-11 中国人民解放军陆军军医大学 抑制猪流行性腹泻病毒M基因表达的shRNA
CN113512534B (zh) * 2020-09-23 2024-04-23 杭州启函生物科技有限公司 用于遗传修饰和靶向的组合物和方法
CN113604502A (zh) * 2021-08-26 2021-11-05 中国农业科学院北京畜牧兽医研究所 pAPN基因第16外显子的基因编辑系统及其应用
WO2024013514A2 (en) * 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2836288A1 (en) * 2011-05-16 2012-11-22 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus resistant animals
US20150275231A1 (en) * 2014-03-31 2015-10-01 Mice With Horns, Llc Method of Preventing or Reducing Virus Transmission in Animals
AU2015404563B2 (en) * 2015-08-06 2022-11-17 The Curators Of The University Of Missouri Pathogen-resistant animals having modified CD163 genes
CN107034218A (zh) * 2017-06-07 2017-08-11 浙江大学 用于猪APN基因编辑的靶向sgRNA、修饰载体及其制备方法和应用
CN107937345B (zh) * 2017-11-16 2019-01-29 山东蓝思种业股份有限公司 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法

Also Published As

Publication number Publication date
JP2021521844A (ja) 2021-08-30
CN112313330A (zh) 2021-02-02
PH12020551629A1 (en) 2021-07-12
AU2019257776A1 (en) 2020-10-22
US20200236914A1 (en) 2020-07-30
CA3096283A1 (en) 2019-10-31
KR20210005661A (ko) 2021-01-14
BR112020021476A2 (pt) 2021-01-19
WO2019210175A1 (en) 2019-10-31

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