MX2020006847A - Nano-particulas que contienen el gangliosido gm3 como inmunomoduladoras. - Google Patents
Nano-particulas que contienen el gangliosido gm3 como inmunomoduladoras.Info
- Publication number
- MX2020006847A MX2020006847A MX2020006847A MX2020006847A MX2020006847A MX 2020006847 A MX2020006847 A MX 2020006847A MX 2020006847 A MX2020006847 A MX 2020006847A MX 2020006847 A MX2020006847 A MX 2020006847A MX 2020006847 A MX2020006847 A MX 2020006847A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- patients
- ganglioside
- myeloid
- treatment
- Prior art date
Links
- 239000002955 immunomodulating agent Substances 0.000 title abstract 2
- 229940121354 immunomodulator Drugs 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- PFJKOHUKELZMLE-VEUXDRLPSA-N ganglioside GM3 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 PFJKOHUKELZMLE-VEUXDRLPSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 GM3 ganglioside Chemical class 0.000 abstract 1
- 241000588650 Neisseria meningitidis Species 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/812—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/868—Vaccine for a specifically defined cancer kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención describe una composición farmacéutica cuyo principio activo incluye conjugados de vesículas de membrana de Neisseria meningitidis y el gangliosido GM3 en una proporción de conjugación en exceso de proteínas, presenta características particulares de talla, carga superficial y una morfología asociada a sistemas nano-particulados que le aportan propiedades ventajosas como inmunomodulador, debido a que induce una disminución conveniente y significativa de las Células Supresoras de Origen Mieloide, con impacto en la respuesta de linfocitos T y en la supervivencia de los pacientes con tumores; la invención describe además el uso de la composición farmacéutica divulgada en el tratamiento del cáncer, particularmente aquellos tipos de cáncer donde las Células Supresoras de Origen Mieloide (MDSC) se encuentran elevadas; así como un método de tratamiento con dicha composición en los pacientes con cáncer y un método para seleccionar aquellos que recibirán dicho tratamiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2017000173A CU20170173A7 (es) | 2017-12-27 | 2017-12-27 | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
| PCT/CU2018/050005 WO2019129313A1 (es) | 2017-12-27 | 2018-12-17 | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006847A true MX2020006847A (es) | 2020-08-24 |
Family
ID=65411690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006847A MX2020006847A (es) | 2017-12-27 | 2018-12-17 | Nano-particulas que contienen el gangliosido gm3 como inmunomoduladoras. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11766462B2 (es) |
| EP (1) | EP3733200A1 (es) |
| JP (1) | JP2021507932A (es) |
| KR (1) | KR20200104366A (es) |
| CN (1) | CN111727052B (es) |
| AR (1) | AR113981A1 (es) |
| AU (1) | AU2018396991A1 (es) |
| BR (1) | BR112020013036A2 (es) |
| CA (1) | CA3087109A1 (es) |
| CO (1) | CO2020008353A2 (es) |
| CU (1) | CU20170173A7 (es) |
| EA (1) | EA202091579A1 (es) |
| MX (1) | MX2020006847A (es) |
| SG (1) | SG11202006272PA (es) |
| TW (1) | TWI721352B (es) |
| WO (1) | WO2019129313A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU20170173A7 (es) | 2017-12-27 | 2019-11-04 | Ct Inmunologia Molecular | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2237750T3 (es) * | 1993-12-09 | 2005-08-01 | Centro De Inmunologia Molecular | Vacuna que comprende factor de crecimiento epidermico autologo humano y su uso. |
| US6149921A (en) | 1993-12-29 | 2000-11-21 | Centro De Inmunologia Molecular | Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment |
| CU22420A1 (es) * | 1993-12-29 | 1996-01-31 | Centro Inmunologia Molecular | Composicion vacunal para el desarrollo de una respuesta contra gangliosidos n glicolilados y su uso para el tratamiento del cancer |
| PE20020572A1 (es) * | 2000-12-06 | 2002-07-31 | Centro Inmunologia Molecular | Preparaciones para potenciar la inmunogenicidad de antigenos poco inmunogenicos |
| CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| CU23257A1 (es) | 2003-02-27 | 2008-01-24 | Centro Inmunologia Molecular | COMPOSICIONES VACUNALES A BASE DE GANGLIOSIDOS PARA LA ADMINISTRACION SUBCUTáNEA |
| CU23403A1 (es) * | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
| GB0506001D0 (en) * | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Novel use |
| CU24070B1 (es) * | 2011-12-27 | 2015-01-29 | Ct De Inmunología Molecular | Composiciones farmacéuticas para el tratamiento de tumores que expresan regf y gangliósidos n-glicolilados gm3 (neugcgm3) |
| CU24299B1 (es) * | 2013-08-02 | 2017-12-08 | Centro De Inmunología Molecular | Composiciones vacunales bivalentes basadas en los receptores de tipo 1 y 2 del factor de crecimiento epidérmico |
| CU20170173A7 (es) | 2017-12-27 | 2019-11-04 | Ct Inmunologia Molecular | Nano-partículas que contienen el gangliósido gm3 como inmunomoduladoras |
-
2017
- 2017-12-27 CU CU2017000173A patent/CU20170173A7/es unknown
-
2018
- 2018-12-17 KR KR1020207021766A patent/KR20200104366A/ko not_active Application Discontinuation
- 2018-12-17 BR BR112020013036-2A patent/BR112020013036A2/pt unknown
- 2018-12-17 EP EP18847186.6A patent/EP3733200A1/en active Pending
- 2018-12-17 AU AU2018396991A patent/AU2018396991A1/en active Pending
- 2018-12-17 CN CN201880089583.6A patent/CN111727052B/zh active Active
- 2018-12-17 MX MX2020006847A patent/MX2020006847A/es unknown
- 2018-12-17 SG SG11202006272PA patent/SG11202006272PA/en unknown
- 2018-12-17 EA EA202091579A patent/EA202091579A1/ru unknown
- 2018-12-17 WO PCT/CU2018/050005 patent/WO2019129313A1/es unknown
- 2018-12-17 US US16/957,597 patent/US11766462B2/en active Active
- 2018-12-17 JP JP2020536186A patent/JP2021507932A/ja active Pending
- 2018-12-17 CA CA3087109A patent/CA3087109A1/en active Pending
- 2018-12-19 AR ARP180103720A patent/AR113981A1/es unknown
- 2018-12-25 TW TW107146961A patent/TWI721352B/zh active
-
2020
- 2020-07-07 CO CONC2020/0008353A patent/CO2020008353A2/es unknown
-
2023
- 2023-08-17 US US18/235,157 patent/US20240033302A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CU20170173A7 (es) | 2019-11-04 |
| TW201938191A (zh) | 2019-10-01 |
| JP2021507932A (ja) | 2021-02-25 |
| CO2020008353A2 (es) | 2020-10-30 |
| EA202091579A1 (ru) | 2020-09-17 |
| CN111727052B (zh) | 2023-08-04 |
| US11766462B2 (en) | 2023-09-26 |
| BR112020013036A2 (pt) | 2020-11-24 |
| EP3733200A1 (en) | 2020-11-04 |
| TWI721352B (zh) | 2021-03-11 |
| KR20200104366A (ko) | 2020-09-03 |
| CN111727052A (zh) | 2020-09-29 |
| AU2018396991A1 (en) | 2020-08-13 |
| US20200330527A1 (en) | 2020-10-22 |
| CA3087109A1 (en) | 2019-07-04 |
| AR113981A1 (es) | 2020-07-08 |
| WO2019129313A1 (es) | 2019-07-04 |
| US20240033302A1 (en) | 2024-02-01 |
| SG11202006272PA (en) | 2020-08-28 |
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