MX2020006026A - Sal de fumarato de (r)-3-(1-(2,3-dicloro-4-(pirazin-2-il)fenil)-2, 2,2-trifluoroetil)-1-metil-1-(1-metilpiperidin-4-il)urea, metodos de preparacion y sus usos. - Google Patents

Sal de fumarato de (r)-3-(1-(2,3-dicloro-4-(pirazin-2-il)fenil)-2, 2,2-trifluoroetil)-1-metil-1-(1-metilpiperidin-4-il)urea, metodos de preparacion y sus usos.

Info

Publication number
MX2020006026A
MX2020006026A MX2020006026A MX2020006026A MX2020006026A MX 2020006026 A MX2020006026 A MX 2020006026A MX 2020006026 A MX2020006026 A MX 2020006026A MX 2020006026 A MX2020006026 A MX 2020006026A MX 2020006026 A MX2020006026 A MX 2020006026A
Authority
MX
Mexico
Prior art keywords
methods
fumarate salt
methylpiperidin
pyrazin
dichloro
Prior art date
Application number
MX2020006026A
Other languages
English (en)
Inventor
Claudio Pietra
Claudio Giuliano
Rubio Silvina Garcia
Mauro Perseghini
Angelo Guainazzi
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of MX2020006026A publication Critical patent/MX2020006026A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El presente documento proporciona distintas modalidades relacionadas con una sal de fumarato de (R)-3-(1-(2, 3- dicloro-4-pirazin-2il)fenil)-2, 2, 2-trifluoroetil)-1metil-1-1-met ilipiperidin-4-il)urea, y métodos de producción y uso de la misma, para tratar afecciones y trastornos relacionados con un aumento del nivel de grelina, como consumo excesivo de alimento, adicción al alcohol y otros trastornos (por ejemplo, síndrome de Prader-Willi). Ademas, proporciona varias modalidades relacionadas con una base libre de HM04 cristalina, diferentes formas cristalinas de la sal de fumarato de HM04 y métodos de producción de las mismas.
MX2020006026A 2017-12-11 2018-12-07 Sal de fumarato de (r)-3-(1-(2,3-dicloro-4-(pirazin-2-il)fenil)-2, 2,2-trifluoroetil)-1-metil-1-(1-metilpiperidin-4-il)urea, metodos de preparacion y sus usos. MX2020006026A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762597236P 2017-12-11 2017-12-11
PCT/US2018/064512 WO2019118298A1 (en) 2017-12-11 2018-12-07 Fumarate salt of (r)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, methods of preparation, and uses thereof

Publications (1)

Publication Number Publication Date
MX2020006026A true MX2020006026A (es) 2020-08-17

Family

ID=64901108

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006026A MX2020006026A (es) 2017-12-11 2018-12-07 Sal de fumarato de (r)-3-(1-(2,3-dicloro-4-(pirazin-2-il)fenil)-2, 2,2-trifluoroetil)-1-metil-1-(1-metilpiperidin-4-il)urea, metodos de preparacion y sus usos.

Country Status (19)

Country Link
US (2) US11299472B2 (es)
EP (1) EP3724176B1 (es)
JP (1) JP7171728B2 (es)
KR (1) KR20200097762A (es)
CN (1) CN111683934B (es)
AU (1) AU2018385438B2 (es)
BR (1) BR112020010803A2 (es)
CA (1) CA3083509A1 (es)
CL (1) CL2020001553A1 (es)
DK (1) DK3724176T3 (es)
EA (1) EA202091402A1 (es)
ES (1) ES2910030T3 (es)
HU (1) HUE058247T2 (es)
IL (1) IL275153A (es)
LT (1) LT3724176T (es)
MA (1) MA51132A (es)
MX (1) MX2020006026A (es)
SI (1) SI3724176T1 (es)
WO (1) WO2019118298A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS63279B1 (sr) 2017-12-11 2022-06-30 Univ Muenchen Tech Psma ligandi za snimanje i endoradioterapiju
CN111303192A (zh) * 2020-03-26 2020-06-19 西安瑞联新材料股份有限公司 一种3-氯-2-萘硼酸的工业化生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders
WO2011060397A1 (en) 2009-11-16 2011-05-19 Schering Corporation Substituted amino heterocycles useful as hiv antagonists
WO2012113103A1 (en) 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
TWI690512B (zh) 2014-03-07 2020-04-11 瑞士商赫爾辛保健股份有限公司 對位取代的不對稱脲及其醫療用途

Also Published As

Publication number Publication date
KR20200097762A (ko) 2020-08-19
HUE058247T2 (hu) 2022-07-28
AU2018385438A8 (en) 2020-06-04
WO2019118298A1 (en) 2019-06-20
CL2020001553A1 (es) 2020-11-06
BR112020010803A2 (pt) 2020-11-10
LT3724176T (lt) 2022-04-25
EP3724176A1 (en) 2020-10-21
JP7171728B2 (ja) 2022-11-15
JP2021505633A (ja) 2021-02-18
ES2910030T3 (es) 2022-05-11
IL275153A (en) 2020-07-30
US20200299260A1 (en) 2020-09-24
EP3724176B1 (en) 2022-01-26
MA51132A (fr) 2020-10-21
CN111683934B (zh) 2024-01-23
CN111683934A (zh) 2020-09-18
AU2018385438A1 (en) 2020-05-28
US11299472B2 (en) 2022-04-12
AU2018385438B2 (en) 2022-12-15
CA3083509A1 (en) 2019-06-20
DK3724176T3 (da) 2022-04-04
SI3724176T1 (sl) 2022-04-29
US11884646B2 (en) 2024-01-30
EA202091402A1 (ru) 2020-09-01
US20220340541A1 (en) 2022-10-27

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