HUE058247T2 - (R)-3-(1-(2,3-Diklór-4-(pirazin-2-il)fenil)-2,2,2-trifluoretil)-1-metil-1-(1-metilpiperidin-4-il)karbamid fumarát sója, elõállítási eljárásai és alkalmazásai - Google Patents

(R)-3-(1-(2,3-Diklór-4-(pirazin-2-il)fenil)-2,2,2-trifluoretil)-1-metil-1-(1-metilpiperidin-4-il)karbamid fumarát sója, elõállítási eljárásai és alkalmazásai

Info

Publication number
HUE058247T2
HUE058247T2 HUE18826892A HUE18826892A HUE058247T2 HU E058247 T2 HUE058247 T2 HU E058247T2 HU E18826892 A HUE18826892 A HU E18826892A HU E18826892 A HUE18826892 A HU E18826892A HU E058247 T2 HUE058247 T2 HU E058247T2
Authority
HU
Hungary
Prior art keywords
methylpiperidin
pyrazin
trifluoroethyl
dichloro
urea
Prior art date
Application number
HUE18826892A
Other languages
English (en)
Inventor
Rubio Silvina Garcia
Mauro Perseghini
Angelo Guainazzi
Claudio Pietra
Claudio Giuliano
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of HUE058247T2 publication Critical patent/HUE058247T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE18826892A 2017-12-11 2018-12-07 (R)-3-(1-(2,3-Diklór-4-(pirazin-2-il)fenil)-2,2,2-trifluoretil)-1-metil-1-(1-metilpiperidin-4-il)karbamid fumarát sója, elõállítási eljárásai és alkalmazásai HUE058247T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762597236P 2017-12-11 2017-12-11

Publications (1)

Publication Number Publication Date
HUE058247T2 true HUE058247T2 (hu) 2022-07-28

Family

ID=64901108

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18826892A HUE058247T2 (hu) 2017-12-11 2018-12-07 (R)-3-(1-(2,3-Diklór-4-(pirazin-2-il)fenil)-2,2,2-trifluoretil)-1-metil-1-(1-metilpiperidin-4-il)karbamid fumarát sója, elõállítási eljárásai és alkalmazásai

Country Status (19)

Country Link
US (2) US11299472B2 (hu)
EP (1) EP3724176B1 (hu)
JP (1) JP7171728B2 (hu)
KR (1) KR20200097762A (hu)
CN (1) CN111683934B (hu)
AU (1) AU2018385438B2 (hu)
BR (1) BR112020010803A2 (hu)
CA (1) CA3083509A1 (hu)
CL (1) CL2020001553A1 (hu)
DK (1) DK3724176T3 (hu)
EA (1) EA202091402A1 (hu)
ES (1) ES2910030T3 (hu)
HU (1) HUE058247T2 (hu)
IL (1) IL275153B1 (hu)
LT (1) LT3724176T (hu)
MA (1) MA51132A (hu)
MX (1) MX2020006026A (hu)
SI (1) SI3724176T1 (hu)
WO (1) WO2019118298A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL274072B1 (en) 2017-12-11 2024-07-01 Univ Muenchen Tech PSMA ligands for imaging and endoradiotherapy
CN111303192A (zh) * 2020-03-26 2020-06-19 西安瑞联新材料股份有限公司 一种3-氯-2-萘硼酸的工业化生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders
WO2011060397A1 (en) 2009-11-16 2011-05-19 Schering Corporation Substituted amino heterocycles useful as hiv antagonists
WO2012113103A1 (en) 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
TWI690512B (zh) 2014-03-07 2020-04-11 瑞士商赫爾辛保健股份有限公司 對位取代的不對稱脲及其醫療用途

Also Published As

Publication number Publication date
CN111683934B (zh) 2024-01-23
EP3724176A1 (en) 2020-10-21
WO2019118298A1 (en) 2019-06-20
IL275153B1 (en) 2024-08-01
JP7171728B2 (ja) 2022-11-15
CA3083509A1 (en) 2019-06-20
MX2020006026A (es) 2020-08-17
US20200299260A1 (en) 2020-09-24
CL2020001553A1 (es) 2020-11-06
BR112020010803A2 (pt) 2020-11-10
EP3724176B1 (en) 2022-01-26
EA202091402A1 (ru) 2020-09-01
CN111683934A (zh) 2020-09-18
ES2910030T3 (es) 2022-05-11
AU2018385438B2 (en) 2022-12-15
MA51132A (fr) 2020-10-21
LT3724176T (lt) 2022-04-25
SI3724176T1 (sl) 2022-04-29
US11884646B2 (en) 2024-01-30
AU2018385438A1 (en) 2020-05-28
DK3724176T3 (da) 2022-04-04
JP2021505633A (ja) 2021-02-18
AU2018385438A8 (en) 2020-06-04
US20220340541A1 (en) 2022-10-27
US11299472B2 (en) 2022-04-12
IL275153A (en) 2020-07-30
KR20200097762A (ko) 2020-08-19

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