MX2020000185A - Formas polimorficas de dasatinib. - Google Patents

Formas polimorficas de dasatinib.

Info

Publication number
MX2020000185A
MX2020000185A MX2020000185A MX2020000185A MX2020000185A MX 2020000185 A MX2020000185 A MX 2020000185A MX 2020000185 A MX2020000185 A MX 2020000185A MX 2020000185 A MX2020000185 A MX 2020000185A MX 2020000185 A MX2020000185 A MX 2020000185A
Authority
MX
Mexico
Prior art keywords
dasatinib
present
butanediol
preparation
provides
Prior art date
Application number
MX2020000185A
Other languages
English (en)
Inventor
Venkata Raghavendracharyulu Palle
Mariappan Kaliappan
Ramakrishna Parameshwar Bhat
Jithendrababu Raghunadhachetty
Vijaybhaskar Reddy Regalla
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of MX2020000185A publication Critical patent/MX2020000185A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona el cocristal de dasatinib-timina y el cocristal de dasatinib-adenina. La presente invención proporciona además solvato de dasatinib-butanodiol. La presente invención proporciona además dasatinib (¿)-1,2- butanodiol cristalino, dasatinib (R)-l, 2-butanodiol cristalino, dasatinib (S)-1,2-butanodiol cristalino y dasatinib (:B-2,3 butanodiol cristalino y procesos para su preparación. La presente invención también proporciona un proceso para la preparación de dasatinib amorfo usando solvato de dasatinib-butanodiol. La presente invención proporciona además la preparación de dasatinib anhidro. La presente invención también proporciona un proceso para la preparación de dasatinib monohidrato a partir de dasatinib anhidro.
MX2020000185A 2017-07-07 2018-07-07 Formas polimorficas de dasatinib. MX2020000185A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN201741024067 2017-07-07
IN201741029965 2017-08-24
IN201841001249 2018-01-11
IN201841007613 2018-02-28
PCT/IB2018/055022 WO2019008555A1 (en) 2017-07-07 2018-07-07 POLYMORPHIC FORMS OF DASATINIB

Publications (1)

Publication Number Publication Date
MX2020000185A true MX2020000185A (es) 2021-01-29

Family

ID=64949779

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020000185A MX2020000185A (es) 2017-07-07 2018-07-07 Formas polimorficas de dasatinib.

Country Status (12)

Country Link
US (1) US11059813B2 (es)
EP (1) EP3649126A4 (es)
JP (1) JP2020526528A (es)
KR (1) KR20200036867A (es)
CN (1) CN111108104A (es)
AU (1) AU2018297710A1 (es)
BR (1) BR112020000302A2 (es)
CA (1) CA3069107A1 (es)
MX (1) MX2020000185A (es)
RU (1) RU2020105723A (es)
SG (1) SG11202000098RA (es)
WO (1) WO2019008555A1 (es)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0009721A (pt) 1999-04-15 2002-02-13 Bristol Myers Squibb Co Inibidores de tirosina quinase de proteìna cìclica
US7491725B2 (en) 2004-02-06 2009-02-17 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
TWI338004B (en) * 2004-02-06 2011-03-01 Bristol Myers Squibb Co Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US20070105867A1 (en) 2005-09-21 2007-05-10 Bristol-Myers Squibb Company Oral administration of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof
JP2010539156A (ja) * 2007-10-23 2010-12-16 テバ ファーマシューティカル インダストリーズ リミティド ダサチニブ多形体およびその調製プロセス
WO2010062715A2 (en) 2008-11-03 2010-06-03 Teva Pharmaceutical Industries Ltd. Polymorphs of dasatinib and process for preparation thereof
WO2010067374A2 (en) 2008-12-08 2010-06-17 Hetero Research Foundation Polymorphs of dasatinib
CN102040596A (zh) * 2009-10-10 2011-05-04 上海希迪制药有限公司 达沙替尼多晶型物及其制备方法
CN102030745B (zh) 2010-11-26 2012-05-09 江苏先声药物研究有限公司 Dasatinib溶剂合物及其制备方法
CN102086195B (zh) * 2011-01-28 2013-04-03 南京卡文迪许生物工程技术有限公司 达沙替尼多晶型物及其制备方法和药用组合物
EP2861589B1 (en) * 2012-06-15 2017-05-17 Basf Se Multicomponent crystals comprising dasatinib and selected cocrystal formers
CZ306598B6 (cs) * 2012-12-06 2017-03-22 Zentiva, K.S. Způsob přípravy a čištění nových i známých polymorfů a solvátů dasatinibu
WO2015049645A2 (en) * 2013-10-04 2015-04-09 Alembic Pharmaceuticals Limited An improved process for the preparation of dasatinib
US20180230140A1 (en) * 2014-06-30 2018-08-16 Basf Se Multicomponent crystals of dasatinib with menthol or vanillin
RU2764074C2 (ru) 2014-08-28 2022-01-13 Байоатла, Ллк Условно активные химерные антигенные рецепторы для модифицированных т-клеток
WO2016178148A1 (en) * 2015-05-05 2016-11-10 Glenmark Pharmaceuticals Limited Process for preparation of dapagliflozin
WO2017002131A1 (en) * 2015-06-29 2017-01-05 Msn Laboratories Private Limited Crystalline forms of n-(2-chloro-6-methy]phenvn-2-[f6-[4-(2-hvdroxvethvl)-l- piperazinvil-2-methvl-4-pvrimidinvllaminol-5-thiazolecarboxamide and their process thereof
US9845303B2 (en) * 2015-10-19 2017-12-19 Cadila Healthcare Limited Process for the preparation of dapagliflozin
WO2017098391A1 (en) * 2015-12-11 2017-06-15 Shilpa Medicare Limited Process for the preparation of dasatinib
BR112018015891A2 (pt) * 2016-02-03 2018-12-26 Dr Reddys Laboratories Ltd formas de estado sólido de dasatinib e processos para sua preparação
WO2017134617A1 (en) * 2016-02-03 2017-08-10 Dr. Reddy's Laboratories Limited Process for the preparation of amorphous dasatinib

Also Published As

Publication number Publication date
EP3649126A1 (en) 2020-05-13
SG11202000098RA (en) 2020-02-27
AU2018297710A1 (en) 2020-02-27
JP2020526528A (ja) 2020-08-31
KR20200036867A (ko) 2020-04-07
BR112020000302A2 (pt) 2020-07-14
EP3649126A4 (en) 2021-04-07
US11059813B2 (en) 2021-07-13
AU2018297710A2 (en) 2020-03-05
US20200377495A1 (en) 2020-12-03
CN111108104A (zh) 2020-05-05
CA3069107A1 (en) 2019-01-10
RU2020105723A (ru) 2021-08-09
WO2019008555A1 (en) 2019-01-10

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