MX2019014435A - Procedimientos para la fabricacion de un arn encapsulado en liposoma. - Google Patents

Procedimientos para la fabricacion de un arn encapsulado en liposoma.

Info

Publication number
MX2019014435A
MX2019014435A MX2019014435A MX2019014435A MX2019014435A MX 2019014435 A MX2019014435 A MX 2019014435A MX 2019014435 A MX2019014435 A MX 2019014435A MX 2019014435 A MX2019014435 A MX 2019014435A MX 2019014435 A MX2019014435 A MX 2019014435A
Authority
MX
Mexico
Prior art keywords
manufacturing
methods
liposome encapsulated
encapsulated rna
rna
Prior art date
Application number
MX2019014435A
Other languages
English (en)
Inventor
Bernard Jean STRODIOT Laurent
Minet Geraldine
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of MX2019014435A publication Critical patent/MX2019014435A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporcionan procedimientos para la fabricación de un sistema de entrega no viral que comprende un liposoma que encapsula ARN usando un dispositivo de microfluidos y composiciones para su uso en el mismo.
MX2019014435A 2017-05-30 2018-05-30 Procedimientos para la fabricacion de un arn encapsulado en liposoma. MX2019014435A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762512501P 2017-05-30 2017-05-30
PCT/IB2018/053850 WO2018220553A1 (en) 2017-05-30 2018-05-30 Methods for manufacturing a liposome encapsulated rna

Publications (1)

Publication Number Publication Date
MX2019014435A true MX2019014435A (es) 2020-01-27

Family

ID=62749125

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014435A MX2019014435A (es) 2017-05-30 2018-05-30 Procedimientos para la fabricacion de un arn encapsulado en liposoma.

Country Status (8)

Country Link
US (1) US20210128474A1 (es)
EP (1) EP3630076A1 (es)
JP (1) JP2020521781A (es)
CN (1) CN110891553A (es)
BR (1) BR112019025104A2 (es)
CA (1) CA3063989A1 (es)
MX (1) MX2019014435A (es)
WO (1) WO2018220553A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107072946B (zh) * 2014-09-05 2022-01-11 诺华股份有限公司 用于递送活性剂的脂质和脂质组合物
US10736847B2 (en) * 2018-07-03 2020-08-11 Becton, Dickinson And Company Inverting device for liposome preparation by centrifugation
FI3864163T3 (fi) 2018-10-09 2024-05-03 Univ British Columbia Koostumukset ja järjestelmät, joihin sisältyvät transfektiokompetentit vesikkelit, joissa ei ole orgaanisia liuottimia eikä pesuaineita, sekä niihin liittyvät menetelmät
CN112888451A (zh) * 2018-10-19 2021-06-01 川斯勒佰尔公司 信使rna的无泵包封
EP3890873A2 (en) * 2018-12-06 2021-10-13 GlaxoSmithKline Biologicals S.A. Microfluidic devices
CA3121430A1 (en) * 2018-12-14 2020-06-18 Glaxosmithkline Biologicals Sa Heterologous prime boost vaccine compositions and methods
EP4021407A1 (en) 2019-08-30 2022-07-06 GlaxoSmithKline Biologicals S.A. Jet mixing lipid nanoparticle manufacturing process
WO2021125805A1 (ko) * 2019-12-20 2021-06-24 주식회사 삼양홀딩스 폴리락트산염을 포함하는 약물전달용 나노입자 조성물 제조용 키트
CA3206923A1 (en) * 2021-02-05 2022-08-11 Zihao Wang Ionizable lipid molecule, preparation method therefor, and application thereof in preparation of lipid nanoparticle
CN112961065B (zh) * 2021-02-05 2023-03-14 嘉晨西海(杭州)生物技术有限公司 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用
WO2022231374A1 (ko) * 2021-04-30 2022-11-03 주식회사 삼양홀딩스 약물을 함유하고 양친성 고분자를 포함하지 않는 나노입자 제조용 키트
EP4387596A1 (en) 2021-08-16 2024-06-26 GlaxoSmithKline Biologicals SA Low-dose lyophilized rna vaccines and methods for preparing and using the same
WO2023021427A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof
CN116120198B (zh) * 2022-03-21 2024-03-15 苏州科锐迈德生物医药科技有限公司 具有甘油骨架的脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂
WO2023183616A1 (en) * 2022-03-25 2023-09-28 Senda Biosciences, Inc. Novel ionizable lipids and lipid nanoparticles and methods of using the same
CN117924106A (zh) * 2022-12-20 2024-04-26 北京剂泰医药科技有限公司 可电离脂质化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107028886A (zh) * 2009-11-04 2017-08-11 不列颠哥伦比亚大学 含有核酸的脂质粒子及相关的方法
PL2611467T3 (pl) * 2010-08-31 2022-08-16 Glaxosmithkline Biologicals Sa Małe liposomy do dostarczania rna kodującego immunogen
EP4119155A1 (en) * 2010-08-31 2023-01-18 GlaxoSmithKline Biologicals S.A. Pegylated liposomes for delivery of immunogen-encoding rna
US20130168885A1 (en) * 2012-01-04 2013-07-04 Donna M. Omiatek Device and method for formation of vesicles
ES2908827T3 (es) * 2013-12-19 2022-05-04 Novartis Ag Lípidos y composiciones lipídicas para el suministro de agentes activos
US10059655B2 (en) * 2013-12-19 2018-08-28 Novartis Ag Lipids and lipid compositions for the delivery of active agents
CN107072946B (zh) 2014-09-05 2022-01-11 诺华股份有限公司 用于递送活性剂的脂质和脂质组合物
AU2016222746A1 (en) * 2015-02-24 2017-09-07 The University Of British Columbia Continuous flow microfluidic system

Also Published As

Publication number Publication date
CN110891553A (zh) 2020-03-17
CA3063989A1 (en) 2018-12-06
WO2018220553A1 (en) 2018-12-06
JP2020521781A (ja) 2020-07-27
EP3630076A1 (en) 2020-04-08
US20210128474A1 (en) 2021-05-06
BR112019025104A2 (pt) 2020-06-23

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