MX2019012827A - Derivados de tetrahidronaftilo urea novedosos. - Google Patents

Derivados de tetrahidronaftilo urea novedosos.

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Publication number
MX2019012827A
MX2019012827A MX2019012827A MX2019012827A MX2019012827A MX 2019012827 A MX2019012827 A MX 2019012827A MX 2019012827 A MX2019012827 A MX 2019012827A MX 2019012827 A MX2019012827 A MX 2019012827A MX 2019012827 A MX2019012827 A MX 2019012827A
Authority
MX
Mexico
Prior art keywords
diseases
tetrahydronaphthyl
novel
solvates
urea derivatives
Prior art date
Application number
MX2019012827A
Other languages
English (en)
Inventor
Saitoh Fumihiko
NAGASUE Hiroshi
KAWADA Yuji
Satoh Tsutomu
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of MX2019012827A publication Critical patent/MX2019012827A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

La invención actual se enfoca en proporcionar un compuesto que tiene una acción inhibidora de TrkA, una sal farmacéuticamente aceptable del mismo, o un solvato del mismo, una composición farmacéutica que contiene el mismo como un ingrediente activo, y un agente preventivo y/o terapéutico para uso medicinal, en particular para una enfermedad en la cual TrkA está involucrada (dolor, cánceres, inflamación/enfermedades inflamatorias, enfermedades alérgicas, enfermedades de la piel, enfermedades neurodegenerativas, enfermedades infecciosas, síndrome de Sjogren, endometriosis, enfermedades renales, osteoporosis, y similares). Específicamente, la invención actual proporciona un compuesto o un isómero óptico del mismo, una sal farmacéuticamente aceptable del mismo, un solvato del mismo, o similares, el compuesto representado por la fórmula (I): (ver formula I).
MX2019012827A 2017-04-27 2018-04-25 Derivados de tetrahidronaftilo urea novedosos. MX2019012827A (es)

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US10399945B2 (en) 2019-09-03
CN110831926A (zh) 2020-02-21
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AU2018257203A1 (en) 2019-10-31
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