MX2019011749A - Reduccion de la expresion de beta-catenina para potenciar la inmunoterapia. - Google Patents

Reduccion de la expresion de beta-catenina para potenciar la inmunoterapia.

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Publication number
MX2019011749A
MX2019011749A MX2019011749A MX2019011749A MX2019011749A MX 2019011749 A MX2019011749 A MX 2019011749A MX 2019011749 A MX2019011749 A MX 2019011749A MX 2019011749 A MX2019011749 A MX 2019011749A MX 2019011749 A MX2019011749 A MX 2019011749A
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MX
Mexico
Prior art keywords
immunotherapy
catenin
potentiate
inhibitor
cancer
Prior art date
Application number
MX2019011749A
Other languages
English (en)
Inventor
Ganesh Shanthi
Abrams Marc
Original Assignee
Dicerna Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dicerna Pharmaceuticals Inc filed Critical Dicerna Pharmaceuticals Inc
Publication of MX2019011749A publication Critical patent/MX2019011749A/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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Abstract

Se proporcionan en la presente métodos y composiciones para tratar el cáncer, que incluye cáncer que no responde a la inmunoterapia; en un aspecto, los métodos de tratamiento comprenden administrarle al sujeto una cantidad terapéuticamente eficaz de un inhibidor de ß- catenina y una cantidad terapéuticamente eficaz de un agente inmunoterapéutico; otro aspecto se dirige a composiciones farmacéuticas que comprenden un inhibidor de ß-catenina para usar en el tratamiento del cáncer, donde la composición se administra en combinación con un agente inmunoterapéutico; aun otro aspecto se dirige a un método para potenciar el efecto terapéutico de la inmunoterapia contra un cáncer usando un inhibidor de ß-catenina, tal como una molécula inhibidora de ácido nucleico de ß-catenina.
MX2019011749A 2017-03-28 2018-03-28 Reduccion de la expresion de beta-catenina para potenciar la inmunoterapia. MX2019011749A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762477783P 2017-03-28 2017-03-28
PCT/US2018/024728 WO2018183420A1 (en) 2017-03-28 2018-03-28 Reducing beta-catenin expression to potentiate immunotherapy

Publications (1)

Publication Number Publication Date
MX2019011749A true MX2019011749A (es) 2020-01-23

Family

ID=63678261

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011749A MX2019011749A (es) 2017-03-28 2018-03-28 Reduccion de la expresion de beta-catenina para potenciar la inmunoterapia.

Country Status (11)

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US (2) US11572559B2 (es)
EP (1) EP3600423A4 (es)
JP (2) JP7295804B2 (es)
KR (1) KR20190128692A (es)
CN (1) CN110461362A (es)
AU (1) AU2018244351A1 (es)
CA (1) CA3057679A1 (es)
IL (1) IL269766A (es)
MX (1) MX2019011749A (es)
NZ (1) NZ757538A (es)
WO (1) WO2018183420A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3084829A1 (en) * 2018-01-05 2019-07-11 Dicerna Pharmaceuticals, Inc. Reducing beta-catenin and ido expression to potentiate immunotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687005A (zh) * 2004-07-09 2010-03-31 加利福尼亚大学董事会 采用抑制Wnt 16信号转导的试剂治疗癌症的方法
EP3587579B1 (en) 2010-07-06 2021-03-03 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of beta-catenin by double-stranded rna
WO2012018754A2 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
CN103370054A (zh) * 2010-11-09 2013-10-23 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
WO2013066721A2 (en) * 2011-11-04 2013-05-10 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of met by double-stranded rna
CA2978450A1 (en) * 2015-03-04 2016-09-09 The University Of Chicago Beta-catenin inhibitors in cancer immunotherapy
WO2017005773A1 (en) 2015-07-07 2017-01-12 Universite de Bordeaux Use of catenin- beta 1-targeting micrornas for treating liver cancer
NZ739503A (en) * 2015-07-16 2023-06-30 Bioxcel Therapeutics Inc A novel approach for treatment of cancer using immunomodulation
JP7097438B2 (ja) * 2017-07-11 2022-07-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用

Also Published As

Publication number Publication date
NZ757538A (en) 2023-07-28
EP3600423A1 (en) 2020-02-05
CA3057679A1 (en) 2018-10-04
AU2018244351A1 (en) 2019-10-17
US20230392148A1 (en) 2023-12-07
CN110461362A (zh) 2019-11-15
US20200377882A1 (en) 2020-12-03
EP3600423A4 (en) 2021-01-13
US11572559B2 (en) 2023-02-07
JP2023073256A (ja) 2023-05-25
JP2020515618A (ja) 2020-05-28
WO2018183420A1 (en) 2018-10-04
IL269766A (en) 2019-11-28
JP7295804B2 (ja) 2023-06-21
KR20190128692A (ko) 2019-11-18

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