MX2019009028A - Metodos para monitoreo no invasivo del agente rastreador fluorescente con correcciones de separacion de fondo. - Google Patents

Metodos para monitoreo no invasivo del agente rastreador fluorescente con correcciones de separacion de fondo.

Info

Publication number
MX2019009028A
MX2019009028A MX2019009028A MX2019009028A MX2019009028A MX 2019009028 A MX2019009028 A MX 2019009028A MX 2019009028 A MX2019009028 A MX 2019009028A MX 2019009028 A MX2019009028 A MX 2019009028A MX 2019009028 A MX2019009028 A MX 2019009028A
Authority
MX
Mexico
Prior art keywords
signal
medium
fluorescent agent
corrections
agent
Prior art date
Application number
MX2019009028A
Other languages
English (en)
Inventor
solomon Edward
KEATING Jennifer
SCHULTZ Kimberly
Bechtel Kate
Original Assignee
Medibeacon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medibeacon Inc filed Critical Medibeacon Inc
Publication of MX2019009028A publication Critical patent/MX2019009028A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7228—Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0488—Optical or mechanical part supplementary adjustable parts with spectral filtering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44—Electric circuits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/027—Control of working procedures of a spectrometer; Failure detection; Bandwidth calculation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/44—Electric circuits
    • G01J2001/4446—Type of detector
    • G01J2001/4453—PMT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0625—Modulated LED

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)

Abstract

Se describe un método para monitorear una fluorescencia variable con el tiempo emitida de un agente fluorescente dentro de un medio de reflexión difusa con propiedades ópticas que varían con el tiempo, que incluye proveer al menos dos mediciones obtenidas de un paciente antes y después de la administración del agente fluorescente que incluye una señal Flrmeas detecta adyacente a un medio por un detector de luz filtrada durante la iluminación del medio por la luz de longitud de onda excitatoria, y al menos una señal DR seleccionada de : una señal DRexmeas DRem, y DRem, filtrada. El método además incluye identificar una porción post-equilibrio del conjunto de datos de la medición y transformar cada señal Flrmeas dentro de la porción de post-equilibrio del conjunto de datos de la medición para una IFagente que representa una intensidad de fluorescencia detectada emitida solamente por el agente fluorescente desde el interior del medio. El método descrito incluye la eliminación de los efectos de la pérdida de luz al nivel de excitación y la eliminación de los efectos de autofluorescencia de la señal Flrmeas.
MX2019009028A 2017-01-30 2018-01-30 Metodos para monitoreo no invasivo del agente rastreador fluorescente con correcciones de separacion de fondo. MX2019009028A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762452021P 2017-01-30 2017-01-30
PCT/US2018/016053 WO2018140984A1 (en) 2017-01-30 2018-01-30 Method for non-invasive monitoring of fluorescent tracer agent with background separation corrections

Publications (1)

Publication Number Publication Date
MX2019009028A true MX2019009028A (es) 2019-12-11

Family

ID=62977380

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009028A MX2019009028A (es) 2017-01-30 2018-01-30 Metodos para monitoreo no invasivo del agente rastreador fluorescente con correcciones de separacion de fondo.

Country Status (16)

Country Link
US (1) US10194854B2 (es)
EP (1) EP3574255A4 (es)
JP (2) JP7165137B2 (es)
KR (1) KR102316452B1 (es)
CN (2) CN114965401A (es)
AU (1) AU2018212019B2 (es)
BR (1) BR112019015561B1 (es)
CA (1) CA3051857A1 (es)
IL (1) IL268333B (es)
MX (1) MX2019009028A (es)
MY (1) MY196727A (es)
PH (1) PH12019501748A1 (es)
RU (2) RU2020113620A (es)
SG (1) SG11201906937YA (es)
WO (1) WO2018140984A1 (es)
ZA (1) ZA201904972B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107532998B (zh) * 2015-03-09 2021-08-03 光谱传感器公司 本质安全的光谱分析仪
WO2019133837A1 (en) * 2017-12-28 2019-07-04 University Of Notre Dame Du Lac Super-resolution fluorescence microscopy by stepwise optical saturation
WO2019213618A1 (en) * 2018-05-03 2019-11-07 Akoya Biosciences, Inc. Multispectral sample imaging
EP4147028A4 (en) * 2020-05-05 2023-11-08 Becton, Dickinson and Company METHOD FOR DETERMINING DETECTOR GAIN IN A FLOW CYTOMETER
GB2597521A (en) * 2020-07-27 2022-02-02 Sensor Coating Systems Ltd Detection system and method
WO2022216778A1 (en) * 2021-04-06 2022-10-13 Berkeley Lights, Inc. Methods of microfluidic assay and bioproduction from non-mammalian cells and kits therefor
CN115728276B (zh) * 2022-11-14 2024-01-23 中船重工安谱（湖北）仪器有限公司 爆炸物检测方法和检测系统

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591981A (en) 1995-03-16 1997-01-07 Bio-Rad Laboratories, Inc. Tunable excitation and/or tunable emission fluorescence imaging
EP1290427B1 (en) * 2000-04-11 2017-08-23 ChemoMetec A/S Method and apparatus for detecting fluorescence of a sample
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US6733744B1 (en) 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
RU2190208C2 (ru) * 2000-12-14 2002-09-27 Государственный научно-исследовательский институт биологического приборостроения Устройство для измерения люминесценции биологических образцов
US6697652B2 (en) * 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
AU2005280455A1 (en) 2004-08-26 2006-03-09 Mallinckrodt Inc. Luminescent metal complexes for monitoring renal function
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20090285761A1 (en) * 2008-04-18 2009-11-19 Pharmacophotonics, Llc D/B/A Fast Diagnostics Renal Function Analysis Method and Apparatus
US20110028806A1 (en) 2009-07-29 2011-02-03 Sean Merritt Reflectance calibration of fluorescence-based glucose measurements
US8314377B2 (en) * 2009-12-23 2012-11-20 Mcneil-Ppc, Inc. Device and method for detecting plaque in the oral cavity
WO2011088571A1 (en) * 2010-01-25 2011-07-28 University Health Network Device, system and method for quantifying fluorescence and optical properties
US8818733B2 (en) * 2010-04-20 2014-08-26 Mayo Foundation For Medical Education And Research Determination of photodynamic therapy (PDT) treatment parameters
GB201014837D0 (en) 2010-09-07 2010-10-20 Immunovia Ab Biomarker signatures and uses thereof
US9155473B2 (en) * 2012-03-21 2015-10-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
CN113274007A (zh) * 2013-03-14 2021-08-20 普罗菲尤萨股份有限公司 用于校正光学信号的方法和装置
HUE043467T2 (hu) * 2013-10-22 2019-08-28 Medibeacon Inc Javított transzkután szervmûködés mérés
US10080484B2 (en) * 2014-01-31 2018-09-25 University Of Washington Multispectral wide-field endoscopic imaging of fluorescence

Also Published As

Publication number Publication date
EP3574255A1 (en) 2019-12-04
CN114965401A (zh) 2022-08-30
JP7357133B2 (ja) 2023-10-05
JP2020507372A (ja) 2020-03-12
KR102316452B1 (ko) 2021-10-26
AU2018212019B2 (en) 2020-05-07
CN110476051B (zh) 2022-09-27
ZA201904972B (en) 2022-05-25
IL268333B (en) 2022-07-01
BR112019015561A2 (pt) 2020-03-17
AU2018212019A1 (en) 2019-08-15
MY196727A (en) 2023-05-03
CN110476051A (zh) 2019-11-19
JP2023011691A (ja) 2023-01-24
BR112019015561B1 (pt) 2023-12-12
SG11201906937YA (en) 2019-08-27
JP7165137B2 (ja) 2022-11-02
WO2018140984A1 (en) 2018-08-02
RU2720132C1 (ru) 2020-04-24
US20180214062A1 (en) 2018-08-02
US10194854B2 (en) 2019-02-05
RU2020113620A (ru) 2020-09-25
CA3051857A1 (en) 2018-08-02
NZ755760A (en) 2021-03-26
PH12019501748A1 (en) 2020-06-01
EP3574255A4 (en) 2020-12-09
KR20190107123A (ko) 2019-09-18
IL268333A (en) 2019-09-26

Similar Documents

Publication Publication Date Title
MX2023002896A (es) Metodo para monitoreo no invasivo de agente trazador fluorescente con correcciones de reflejo difuso.
MX2019009028A (es) Metodos para monitoreo no invasivo del agente rastreador fluorescente con correcciones de separacion de fondo.
BR112015022216A2 (pt) método e dispositivo para correção de sinais ópticos
ATE556671T1 (de) Ophthalmologisches implantat mit markierung zu dessen detektion und/oder identifikation
ATE507544T1 (de) Rauchdetektion mittels zweier spektral unterschiedlicher streulichtmessungen
MX362127B (es) Medicion de un analito fluorecente usando excitacion tisular.
JP2016515003A5 (es)
BR112015011854A2 (pt) detecção acústica distribuída em fundo de furo
MX2010003438A (es) Sistema capilar con elemento fluidico.
GB201307338D0 (en) Methods related to instrument-independent measurements for quantitive analysis of fiber-optic Raman sepctroscopy
WO2009131655A3 (en) Automated assessment of optic nerve head with spectral domain optical coherence tomograph
BRPI1005662A8 (pt) Dispositivo e método para detectar placas na cavidade bucal
EA201070863A1 (ru) Способы детекции признаков заболеваний или состояний в жидкостях организма
EP2392900A3 (en) Interferometer
SG11201802651PA (en) System and method for optically measuring the stability and aggregation of particles
IL236836B (en) Optical method and system for measuring isolated elements of a structure
MD3370515T2 (ro) Dispozitiv pentru detectarea ploșnițelor de pat
PL411223A1 (pl) Sposób bezinwazyjnego pomiaru glukozy we krwi i układ optoelektroniczny do bezinwazyjnego pomiaru glukozy we krwi
WO2014027794A1 (ko) 비가시광 형광신호의 실시간 가시화를 위한 형광영상의 획득투사장치
GB2517865A (en) Real time optical detection of bacteria
ES2570609T3 (es) Método para someter a ensayo la aminoacilasa 1 para el diagnóstico in vitro del cáncer colorrectal
EP2378277A3 (de) Sensor und Verfahren zur Online Überwachung der Säurezahl eines Hydraulikfluids in einem Hydrauliksystem in einem Luftfahrzeug
BR112020021901B1 (pt) Método para determinar uma profundidade de uma concentração do fluoróforo e dispositivo para quantificar e determinar a profundidade das concentrações de fluoróforos
EP2589666A4 (en) ACF DETECTION METHOD
GB2569932A (en) Identification and use of very long chain dicarboxylic acids for disease diagnosis, chemoprevention, and treatment