MX362127B - Medicion de un analito fluorecente usando excitacion tisular. - Google Patents

Medicion de un analito fluorecente usando excitacion tisular.

Info

Publication number
MX362127B
MX362127B MX2014003234A MX2014003234A MX362127B MX 362127 B MX362127 B MX 362127B MX 2014003234 A MX2014003234 A MX 2014003234A MX 2014003234 A MX2014003234 A MX 2014003234A MX 362127 B MX362127 B MX 362127B
Authority
MX
Mexico
Prior art keywords
measurement
fluorescent analyte
blood
fluorescent
analyte
Prior art date
Application number
MX2014003234A
Other languages
English (en)
Other versions
MX2014003234A (es
Inventor
M Brittenham Gary
Stepp Herbert
Hennig Georg
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of MX2014003234A publication Critical patent/MX2014003234A/es
Publication of MX362127B publication Critical patent/MX362127B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/001—Optical devices or arrangements for the control of light using movable or deformable optical elements based on interference in an adjustable optical cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Audiology, Speech & Language Pathology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La presente invención se refiere a un aparato (100) para la medición no invasiva de una concentración de un analito fluorescente en la sangre de un paciente, caracterizado porque comprende: una fuente de luz (102) para proporcionar alternativamente la excitación del analito y la sangre en un primer intervalo de longitudes de onda y un segundo intervalo de longitudes de onda, el primer y segundo intervalos de longitud de onda de excitación seleccionados de tal manera que el analito exhiba una diferencia en intensidades de emisión en el primer y segundo intervalos de longitud de onda de excitación y de tal manera que la absorbancia de luz de la sangre en el primer y segundo intervalos de longitud de onda sea similar; uno o más detectores (104) para detectar una porción de los espectros de emisión del analito fluorescente en el primer intervalo de longitudes de onda de excitación y el segundo intervalo de longitudes de onda de excitación; y un procesador (100) adaptado para determinar una señal derivada representativa de la concentración del analito con base en la diferencia entre la parte de los espectros de emisión excitados en el primer intervalo de longitudes de onda de excitación y el segundo intervalo de longitudes de onda de excitación.
MX2014003234A 2011-09-15 2012-09-14 Medicion de un analito fluorecente usando excitacion tisular. MX362127B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535064P 2011-09-15 2011-09-15
PCT/US2012/055492 WO2013040398A1 (en) 2011-09-15 2012-09-14 Measurement of a fluorescent analyte using tissue excitation

Publications (2)

Publication Number Publication Date
MX2014003234A MX2014003234A (es) 2014-12-05
MX362127B true MX362127B (es) 2019-01-07

Family

ID=47883782

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003234A MX362127B (es) 2011-09-15 2012-09-14 Medicion de un analito fluorecente usando excitacion tisular.

Country Status (10)

Country Link
US (2) US9999382B2 (es)
EP (1) EP2756303B1 (es)
JP (1) JP2014530668A (es)
CN (1) CN103930782A (es)
CA (1) CA2848737A1 (es)
ES (1) ES2689176T3 (es)
IL (1) IL231442A0 (es)
MX (1) MX362127B (es)
WO (1) WO2013040398A1 (es)
ZA (1) ZA201402730B (es)

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WO2015054684A1 (en) * 2013-10-11 2015-04-16 The Trustees Of Columbia University In The City Of New York System, method and computer-accessible medium for characterization of tissue
JP6612050B2 (ja) * 2014-08-28 2019-11-27 シスメックス株式会社 血液分析装置、診断支援方法、およびコンピュータプログラム
JP6204314B2 (ja) 2014-09-03 2017-09-27 Hoya株式会社 電子内視鏡システム
CN106999118B (zh) * 2014-10-13 2020-07-17 葡萄糖传感器公司 分析物感测装置
JP6356051B2 (ja) * 2014-11-21 2018-07-11 Hoya株式会社 分析装置及び分析装置の作動方法
CN107636446B (zh) * 2015-02-18 2021-11-23 H·施特普 用于血液荧光团确定的组织荧光测量的装置和方法
CN104833813B (zh) * 2015-05-12 2017-03-29 江苏英诺华医疗技术有限公司 一种同时具有血液常规和生化检测功能的分析仪
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ITUB20160237A1 (it) * 2016-01-26 2017-07-26 Vision Engineering Italy Soc A Responsabilita Limitata Apparato di controllo del dosaggio di un agente cromoforo in un tessuto corneale e procedimento per dosare un agente cromoforo in un tessuto corneale
CN110402385A (zh) * 2016-12-15 2019-11-01 美国杰莫洛吉克尔研究所有限公司 用于筛选宝石的装置和方法
DE102017101309A1 (de) 2016-12-23 2018-06-28 Georg Hennig Verfahren zum quantitativen Bestimmen einer fluoreszierenden Komponente in Blut und Messgerät
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Also Published As

Publication number Publication date
ES2689176T3 (es) 2018-11-08
WO2013040398A1 (en) 2013-03-21
US9999382B2 (en) 2018-06-19
CN103930782A (zh) 2014-07-16
EP2756303A1 (en) 2014-07-23
EP2756303B1 (en) 2018-08-22
EP2756303A4 (en) 2015-04-15
US20190110718A1 (en) 2019-04-18
US20140235973A1 (en) 2014-08-21
ZA201402730B (en) 2016-11-30
CA2848737A1 (en) 2013-03-21
MX2014003234A (es) 2014-12-05
IL231442A0 (en) 2014-04-30
JP2014530668A (ja) 2014-11-20

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