MX2019008920A - Moduladores de rorgamma y usos de los mismos. - Google Patents
Moduladores de rorgamma y usos de los mismos.Info
- Publication number
- MX2019008920A MX2019008920A MX2019008920A MX2019008920A MX2019008920A MX 2019008920 A MX2019008920 A MX 2019008920A MX 2019008920 A MX2019008920 A MX 2019008920A MX 2019008920 A MX2019008920 A MX 2019008920A MX 2019008920 A MX2019008920 A MX 2019008920A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- rorgamma
- modulators
- autoimmune
- compounds
- Prior art date
Links
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000001587 cholestatic effect Effects 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona novedosos compuestos que son moduladores de RORgamma. Estos compuestos, y las composiciones farmacéuticas que comprenden los mismos, son medios adecuados para tratar cualquier enfermedad en la que la modulación de RORgamma tenga efectos terapéuticos, por ejemplo en enfermedades autoinmunitarias, enfermedades de tipo autoinmunitario, enfermedades inflamatorias, enfermedades metabólicas, enfermedades fibróticas o enfermedades colestásicas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17305091 | 2017-01-27 | ||
EP17178889 | 2017-06-29 | ||
PCT/EP2018/052163 WO2018138356A1 (en) | 2017-01-27 | 2018-01-29 | Rorgamma modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019008920A true MX2019008920A (es) | 2019-12-09 |
Family
ID=61017942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019008920A MX2019008920A (es) | 2017-01-27 | 2018-01-29 | Moduladores de rorgamma y usos de los mismos. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11160801B2 (es) |
EP (1) | EP3573974A1 (es) |
JP (1) | JP7138647B2 (es) |
KR (1) | KR20190112009A (es) |
CN (1) | CN110177782A (es) |
AU (1) | AU2018212618A1 (es) |
BR (1) | BR112019015399A2 (es) |
CA (1) | CA3050045A1 (es) |
IL (1) | IL268150A (es) |
MX (1) | MX2019008920A (es) |
PH (1) | PH12019501683A1 (es) |
SG (1) | SG11201906871XA (es) |
WO (1) | WO2018138356A1 (es) |
ZA (1) | ZA201905513B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023550793A (ja) | 2020-11-26 | 2023-12-05 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 縮合三環式化合物、その調製方法及びその医薬的応用 |
EP4342884A1 (en) | 2021-05-19 | 2024-03-27 | Shanghai de Novo Pharmatech Co., Ltd. | Nitrogen-containing compound, conjugate containing said compound, and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR036375A1 (es) | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
AR059224A1 (es) | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
US9902725B2 (en) | 2014-12-23 | 2018-02-27 | Genfit | Heterocyclic derivatives as RORgamma modulators |
WO2017010399A1 (ja) * | 2015-07-10 | 2017-01-19 | 塩野義製薬株式会社 | RORγt阻害作用を有する化合物およびそれらを含有する医薬組成物 |
-
2018
- 2018-01-29 EP EP18701056.6A patent/EP3573974A1/en active Pending
- 2018-01-29 SG SG11201906871XA patent/SG11201906871XA/en unknown
- 2018-01-29 US US16/481,172 patent/US11160801B2/en active Active
- 2018-01-29 BR BR112019015399-3A patent/BR112019015399A2/pt not_active Application Discontinuation
- 2018-01-29 CN CN201880007080.XA patent/CN110177782A/zh active Pending
- 2018-01-29 MX MX2019008920A patent/MX2019008920A/es unknown
- 2018-01-29 AU AU2018212618A patent/AU2018212618A1/en not_active Abandoned
- 2018-01-29 WO PCT/EP2018/052163 patent/WO2018138356A1/en unknown
- 2018-01-29 JP JP2019541139A patent/JP7138647B2/ja active Active
- 2018-01-29 KR KR1020197024251A patent/KR20190112009A/ko unknown
- 2018-01-29 CA CA3050045A patent/CA3050045A1/en not_active Abandoned
-
2019
- 2019-07-18 IL IL268150A patent/IL268150A/en unknown
- 2019-07-22 PH PH12019501683A patent/PH12019501683A1/en unknown
- 2019-08-21 ZA ZA2019/05513A patent/ZA201905513B/en unknown
-
2021
- 2021-10-05 US US17/494,458 patent/US11974997B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20220133716A1 (en) | 2022-05-05 |
EP3573974A1 (en) | 2019-12-04 |
BR112019015399A2 (pt) | 2020-03-31 |
AU2018212618A1 (en) | 2019-08-29 |
US11160801B2 (en) | 2021-11-02 |
JP2020505412A (ja) | 2020-02-20 |
ZA201905513B (en) | 2020-05-27 |
SG11201906871XA (en) | 2019-08-27 |
KR20190112009A (ko) | 2019-10-02 |
CA3050045A1 (en) | 2018-08-02 |
WO2018138356A1 (en) | 2018-08-02 |
CN110177782A (zh) | 2019-08-27 |
IL268150A (en) | 2019-09-26 |
PH12019501683A1 (en) | 2020-06-15 |
US20190388414A1 (en) | 2019-12-26 |
JP7138647B2 (ja) | 2022-09-16 |
US11974997B2 (en) | 2024-05-07 |
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