MX2019006726A - Receptores de celulas t con apareamiento mejorado. - Google Patents
Receptores de celulas t con apareamiento mejorado.Info
- Publication number
- MX2019006726A MX2019006726A MX2019006726A MX2019006726A MX2019006726A MX 2019006726 A MX2019006726 A MX 2019006726A MX 2019006726 A MX2019006726 A MX 2019006726A MX 2019006726 A MX2019006726 A MX 2019006726A MX 2019006726 A MX2019006726 A MX 2019006726A
- Authority
- MX
- Mexico
- Prior art keywords
- cell receptors
- improved pairing
- modified
- amino acid
- pairing
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Abstract
La presente invención se relaciona con cadenas a o ß modificadas de receptor de célula T (TCR), o heterodímeros que comprenden las mismas, en donde en el dominio variable de dicha cadena a o ß modificada, se sustituye un aminoácido en la posición 44 de acuerdo con la numeración de IMGT por otro aminoácido adecuado con el objetivo de mejorar el apareamiento de cadenas deseadas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662497895P | 2016-12-08 | 2016-12-08 | |
DE102016123893.7A DE102016123893A1 (de) | 2016-12-08 | 2016-12-08 | T-Zellrezeptoren mit verbesserter Bindung |
PCT/EP2017/081745 WO2018104407A1 (en) | 2016-12-08 | 2017-12-06 | T cell receptors with improved pairing |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019006726A true MX2019006726A (es) | 2019-09-04 |
Family
ID=62201182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006726A MX2019006726A (es) | 2016-12-08 | 2017-12-06 | Receptores de celulas t con apareamiento mejorado. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11072645B2 (es) |
EP (1) | EP3551653B1 (es) |
JP (1) | JP7346294B2 (es) |
CN (1) | CN110099923A (es) |
AU (1) | AU2017371260C1 (es) |
BR (1) | BR112019010803A2 (es) |
CA (1) | CA3045230A1 (es) |
CR (1) | CR20190280A (es) |
DE (1) | DE102016123893A1 (es) |
MA (1) | MA47359A (es) |
MX (1) | MX2019006726A (es) |
PE (1) | PE20191150A1 (es) |
TW (1) | TWI710572B (es) |
WO (1) | WO2018104407A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
DE102017106305A1 (de) | 2017-03-23 | 2018-09-27 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapien gegen prame-positive Krebsarten |
DE102017125888A1 (de) | 2017-11-06 | 2019-05-23 | Immatics Biotechnologies Gmbh | Neue konstruierte T-Zell-Rezeptoren und deren Verwendung in Immuntherapie |
EP4219543A1 (en) | 2017-11-06 | 2023-08-02 | Immatics Biotechnologies GmbH | Novel engineered t cell receptors and immune therapy using the same |
DE102019108125B4 (de) | 2019-03-28 | 2022-02-03 | Immatics US, Inc. | Cd28 t-zellkulturen, zusammensetzungen und verfahren zu deren verwendung |
WO2020191172A1 (en) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
JP2022534716A (ja) | 2019-05-27 | 2022-08-03 | イマティクス ユーエス,アイエヌシー. | ウイルスベクターおよびその養子細胞療法における使用 |
DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
EP4090365A1 (en) | 2020-01-15 | 2022-11-23 | Immatics Biotechnologies GmbH | Antigen binding proteins specifically binding prame |
JP2023515131A (ja) | 2020-02-24 | 2023-04-12 | イマティクス ユーエス,アイエヌシー. | がんおよび関連する悪性腫瘍の治療のためにt細胞を増殖させる方法 |
DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
TW202227616A (zh) | 2020-08-21 | 2022-07-16 | 美商英麥提克斯股份有限公司 | 分離cd8+選擇t細胞的方法 |
EP4271481A2 (en) | 2020-12-31 | 2023-11-08 | Immatics US, Inc. | Cd8 polypeptides, compositions, and methods of using thereof |
WO2022184805A1 (en) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein |
AU2022270361A1 (en) | 2021-05-05 | 2023-11-16 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
AU2022318257A1 (en) | 2021-07-27 | 2024-02-08 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding ct45 |
WO2023044488A1 (en) | 2021-09-20 | 2023-03-23 | Immatics US, Inc. | Monocyte depletion of t cells populations for t-cell therapy |
US20230142468A1 (en) | 2021-11-08 | 2023-05-11 | Immatics US, Inc. | Methods for generating cell spheroids |
US20230192886A1 (en) | 2021-11-08 | 2023-06-22 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
EP4198052A1 (en) | 2021-12-15 | 2023-06-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Peptides and antigen binding proteins for use in immunotherapy against fibrolamellar hepatocellular carcinoma (fl-hcc) and other cancers |
US20240066127A1 (en) | 2022-04-28 | 2024-02-29 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
WO2023212697A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
WO2023212691A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | DOMINANT NEGATIVE TGFβ RECEPTOR POLYPEPTIDES, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF |
WO2023215825A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2244744A1 (en) * | 1996-02-01 | 1997-08-07 | University Of Florida | Lyst1 and lyst2 gene compositions and methods of use |
DE10225139A1 (de) | 2002-05-29 | 2004-02-26 | Immatics Biotechnologies Gmbh | Verfahren zur Identifizierung von immunreaktiven Peptiden |
DE10225144A1 (de) | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
DE10313819A1 (de) | 2003-03-24 | 2004-10-07 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
EP1714157A2 (en) | 2004-01-28 | 2006-10-25 | Immatics Biotechnologies GmbH | Method for identifying and quantifying of tumour-associated peptides |
DE102004026135A1 (de) | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
ATE512160T1 (de) | 2005-04-26 | 2011-06-15 | Immatics Biotechnologies Gmbh | T-cell-epitope aus dem unreifen lamininrezeptorprotein (oncofoetal antigen) und deren medizinische verwendungen |
PT1806358E (pt) | 2005-09-05 | 2010-05-28 | Immatics Biotechnologies Gmbh | Peptídeos associados a tumor ligando promiscuamente às moléculas do antigénio de leucócitos humanos (hla) da classe ii |
ATE440107T1 (de) | 2005-09-05 | 2009-09-15 | Immatics Biotechnologies Gmbh | Tumorassoziierte peptide, die hla klasse i oder ii-moleküle binden, und anti-tumor impfstoffe |
SI2567707T1 (sl) | 2007-07-27 | 2017-01-31 | Immatics Biotechnologies Gmbh | Sestava s tumorjem povezanih peptidov in zadevnih cepiv proti raku |
PT2660248E (pt) | 2007-07-27 | 2015-10-12 | Immatics Biotechnologies Gmbh | Nova imunoterapia para tumores neuronais e cerebrais |
CA2694805C (en) | 2007-07-27 | 2014-09-09 | Immatics Biotechnologies Gmbh | Immunogenic epitopes of tumour-associated antigens |
DK2288700T3 (en) * | 2008-05-09 | 2017-05-22 | Agency Science Tech & Res | HBV EPITOP-REACTIVE EXOGEN T-CELL RECEPTOR (TCR) AND APPLICATIONS THEREOF |
NO2119726T3 (es) | 2008-05-14 | 2015-05-23 | ||
PT2172211E (pt) | 2008-10-01 | 2015-03-09 | Immatics Biotechnologies Gmbh | Composição de peptídeos associados a tumores e vacina anti -cancro relacionada para o tratamento de glioblastoma (gbm) e outros tipos de câncer |
GB0917094D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
US9023802B2 (en) | 2009-12-14 | 2015-05-05 | Immatics Biotechnologies Gmbh | HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
GB201004575D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
GB201019331D0 (en) | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
GB201009222D0 (en) | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
GB201015765D0 (en) | 2010-09-21 | 2010-10-27 | Immatics Biotechnologies Gmbh | Use of myeloid cell biomarkers for the diagnosis of cancer |
GB201021289D0 (en) | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
KR20130126671A (ko) | 2010-12-14 | 2013-11-20 | 이매틱스 바이오테크놀로지스 게엠베하 | 전립선 관련 항원 분자로부터 유래된 hla 결합 펩티드 및 이의 사용방법 |
GB2508414A (en) | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
JP6346266B2 (ja) | 2013-03-21 | 2018-06-20 | サンガモ セラピューティクス, インコーポレイテッド | 操作されたジンクフィンガータンパク質ヌクレアーゼを使用するt細胞受容体遺伝子の標的化された破壊 |
TWI777194B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(一) |
PE20150600A1 (es) | 2013-10-15 | 2015-06-03 | Vignolo Carlos Alberto Ibanez | CICLO - BICICLETA HIBRIDA MOTORIZADA 2 x 2 |
GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
GB201411037D0 (en) | 2014-06-20 | 2014-08-06 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL) |
GB2528124A (en) | 2014-07-11 | 2016-01-13 | Nec Corp | Communication system |
TWI617841B (zh) | 2014-10-22 | 2018-03-11 | 英特爾股份有限公司 | 用於光學系統的防雲紋圖樣擴散器 |
WO2016064317A1 (en) | 2014-10-24 | 2016-04-28 | Telefonaktiebolaget L M Ericsson (Publ) | Method and arrangement for csi-rs transmission |
CN104460328B (zh) | 2014-10-29 | 2019-05-10 | 小米科技有限责任公司 | 基于设定场景模式的智能设备控制方法和装置 |
DE102014016105A1 (de) | 2014-10-30 | 2016-05-04 | Head Technology Gmbh | Superelastische Schlägersaite |
TWI752410B (zh) | 2014-10-30 | 2022-01-11 | 美商艾科詹瑟斯有限公司 | 由混合固體廢棄物形成之固體燃料組合物 |
MA40904A (fr) | 2014-11-03 | 2017-09-12 | Hygeia Tech Inc | Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie |
EP3215164A1 (en) | 2014-11-03 | 2017-09-13 | Immures S.r.l. | T cell receptors |
WO2016073587A1 (en) | 2014-11-04 | 2016-05-12 | Spinal Stabilization Technologies Llc | Percutaneous implantable nuclear prosthesis |
CA2967241C (en) | 2014-11-17 | 2023-01-31 | Mitrassist Medical Ltd. | Heart valve prosthesis |
US10207318B2 (en) | 2014-11-20 | 2019-02-19 | Abb Schweiz Ag | Electromagnetic brake system and method of controlling molten metal flow in a metal-making process |
DE102014223758A1 (de) | 2014-11-20 | 2016-05-25 | Windmöller & Hölscher Kg | Kontaktwalze |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
EP3067366A1 (en) | 2015-03-13 | 2016-09-14 | Max-Delbrück-Centrum Für Molekulare Medizin | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
GB201504502D0 (en) | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
GB201510771D0 (en) | 2015-06-19 | 2015-08-05 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer |
GB201511191D0 (en) | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
GB201511792D0 (en) | 2015-07-06 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers |
MY189596A (en) | 2015-07-15 | 2022-02-18 | Immatics Biotechnologies Gmbh | A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
GB201517538D0 (en) | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
JP6862435B2 (ja) | 2015-10-09 | 2021-04-21 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 抗wt1/hla特異的抗体 |
GB201521746D0 (en) | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
GB201522667D0 (en) | 2015-12-22 | 2016-02-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
-
2016
- 2016-12-08 DE DE102016123893.7A patent/DE102016123893A1/de active Pending
-
2017
- 2017-12-06 WO PCT/EP2017/081745 patent/WO2018104407A1/en unknown
- 2017-12-06 US US15/833,778 patent/US11072645B2/en active Active
- 2017-12-06 EP EP17825761.4A patent/EP3551653B1/en active Active
- 2017-12-06 PE PE2019001163A patent/PE20191150A1/es unknown
- 2017-12-06 BR BR112019010803A patent/BR112019010803A2/pt unknown
- 2017-12-06 MA MA047359A patent/MA47359A/fr unknown
- 2017-12-06 AU AU2017371260A patent/AU2017371260C1/en active Active
- 2017-12-06 JP JP2019529260A patent/JP7346294B2/ja active Active
- 2017-12-06 CR CR20190280A patent/CR20190280A/es unknown
- 2017-12-06 CN CN201780075297.XA patent/CN110099923A/zh active Pending
- 2017-12-06 MX MX2019006726A patent/MX2019006726A/es unknown
- 2017-12-06 CA CA3045230A patent/CA3045230A1/en active Pending
- 2017-12-08 TW TW106143062A patent/TWI710572B/zh active
-
2021
- 2021-06-22 US US17/354,555 patent/US20210380659A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112019010803A2 (pt) | 2019-10-01 |
US20210380659A1 (en) | 2021-12-09 |
CR20190280A (es) | 2019-10-07 |
EP3551653A1 (en) | 2019-10-16 |
CN110099923A (zh) | 2019-08-06 |
US11072645B2 (en) | 2021-07-27 |
AU2017371260C1 (en) | 2020-11-19 |
JP7346294B2 (ja) | 2023-09-19 |
WO2018104407A1 (en) | 2018-06-14 |
US20180162922A1 (en) | 2018-06-14 |
JP2020500525A (ja) | 2020-01-16 |
DE102016123893A1 (de) | 2018-06-14 |
EP3551653B1 (en) | 2023-11-01 |
PE20191150A1 (es) | 2019-09-02 |
AU2017371260A1 (en) | 2019-06-20 |
CA3045230A1 (en) | 2018-06-14 |
AU2017371260B2 (en) | 2020-07-23 |
MA47359A (fr) | 2019-12-04 |
TWI710572B (zh) | 2020-11-21 |
TW201827460A (zh) | 2018-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019006726A (es) | Receptores de celulas t con apareamiento mejorado. | |
ECSP18007905A (es) | Anticuerpos monoclonales contra bcma | |
CL2016000221A1 (es) | Anticuerpos anti-fgfr2iiib afucosilados. | |
CL2016002455A1 (es) | Anticuerpos multiespecíficos. | |
MX2016007438A (es) | Pelicula de bopp con balance mejorado de rigidez/resistencia. | |
EA201800273A1 (ru) | Композиция полипропилена для элемента слоя | |
MX2014008801A (es) | Nueva composicion espesante que comprende almidon pregelatinizado de papa ceroso o almidon pregelatinizado de mandioca. | |
EA201700547A1 (ru) | Армированная волокнами полимерная композиция | |
BR112017013863A2 (pt) | processo para formar interpolímeros de etileno/alfa-olefina | |
MX2017002632A (es) | Composicion de polipropileno para pelicula de capacitor. | |
MX2018007220A (es) | Composicion de polipropileno reforzado con fibras de peso ligero. | |
EA201891741A1 (ru) | Эластомерные сополимеры на основе [бис(тригидрокарбилсилил)аминосилил]-функционализованного стирола и их применение при получении каучуков | |
EA201700136A1 (ru) | Полимерная композиция для слоя элемента слоя | |
TR201910057T4 (tr) | Kauçuk bi̇leşi̇mleri̇ | |
WO2015176162A8 (en) | Methods for determining lymphocyte receptor chain pairs | |
EA201700142A1 (ru) | Полимерная композиция для слоя элемента слоя | |
BR112014004794A2 (pt) | composição, composição reticulada e artigo | |
EA201991032A1 (ru) | Композиция полипропилена | |
PH12019501243A1 (en) | T cell receptors with improved pairing | |
EA201991145A1 (ru) | T-клеточные рецепторы с улучшенной способностью к спариванию | |
EA201800209A1 (ru) | Полипропиленовые трубы с улучшенным сопротивлением давлению | |
MX2017005905A (es) | Composicion para extension de cadenas polimericas. | |
CY1120957T1 (el) | Μεθοδος παρασκευης πεναμων | |
MY191754A (en) | Benzothiazole-containing silanes, method for the preparation and use thereof | |
TR201819601U5 (tr) | Fonksi̇yonel çanta |