MX2019005722A - Procedimiento simplificado para la preparacion de darunavir. - Google Patents
Procedimiento simplificado para la preparacion de darunavir.Info
- Publication number
- MX2019005722A MX2019005722A MX2019005722A MX2019005722A MX2019005722A MX 2019005722 A MX2019005722 A MX 2019005722A MX 2019005722 A MX2019005722 A MX 2019005722A MX 2019005722 A MX2019005722 A MX 2019005722A MX 2019005722 A MX2019005722 A MX 2019005722A
- Authority
- MX
- Mexico
- Prior art keywords
- darunavir
- amino
- hexahydrofuro
- furan
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
- Devices For Medical Bathing And Washing (AREA)
Abstract
La presente invención se refiere a un proceso mejorado para preparar el ester (3R,3aS,6aR)-hexahidrofuro[2,3-b]furan-3-ilico del acido [(1S,2R)-3-[[(4-aminofenil)sulfonil](2- metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamico - compuesto que tambien es conocido segun su INN como darunavir - haciendo reaccionar el ester [(3R,3aS,6aR)-hexahidrofuro[2,3- b]furan-3-ilico] y 2,5-dioxo-1-pirrolidinilico del acido carbonico con 4-amino-N-[(2R,3S)-3-amino-2- hidroxi-4-fenilbutil]- N-(2-metilpropil)bencenosulfonamida en etanol como disolvente; ademas, dicho proceso permite aislar inmediatamente el darunavir en su forma de etanolato, es decir, monoetanolato de darunavir, que es la forma comercial de darunavir, cuya marca registrada es Prezista(tm).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16199275 | 2016-11-17 | ||
| PCT/EP2017/079375 WO2018091559A1 (en) | 2016-11-17 | 2017-11-16 | A simplified procedure for the preparation of darunavir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019005722A true MX2019005722A (es) | 2019-07-08 |
Family
ID=57389216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019005722A MX2019005722A (es) | 2016-11-17 | 2017-11-16 | Procedimiento simplificado para la preparacion de darunavir. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10774088B2 (es) |
| EP (1) | EP3541819B1 (es) |
| JP (1) | JP7035049B2 (es) |
| KR (1) | KR102506813B1 (es) |
| CN (1) | CN110291091B (es) |
| AU (1) | AU2017361799B2 (es) |
| BR (1) | BR112019009675A2 (es) |
| CA (1) | CA3041393A1 (es) |
| CY (1) | CY1123830T1 (es) |
| DK (1) | DK3541819T3 (es) |
| ES (1) | ES2854003T3 (es) |
| HR (1) | HRP20202000T1 (es) |
| HU (1) | HUE053006T2 (es) |
| MX (1) | MX2019005722A (es) |
| PL (1) | PL3541819T3 (es) |
| PT (1) | PT3541819T (es) |
| RU (1) | RU2745740C2 (es) |
| SI (1) | SI3541819T1 (es) |
| WO (1) | WO2018091559A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102506813B1 (ko) | 2016-11-17 | 2023-03-06 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 간소화된 다루나비르 제조 절차 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME01059B (me) * | 2003-12-23 | 2012-10-20 | Janssen Sciences Ireland Uc | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata |
| PL1725566T3 (pl) * | 2003-12-23 | 2009-11-30 | Janssen Sciences Ireland Uc | Sposób wytwarzania (1s,2r)-3-[[(4-aminofenylo)sulfonylo](izobutylo)amino]-1-benzylo-2-hydroksypropylokarbaminianu (3r,3as,6ar)-heksahydrofuro-[2,3-b]furan-3-ylu |
| TWI385173B (zh) * | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
| EP2217548A1 (en) | 2007-10-26 | 2010-08-18 | Concert Pharmaceuticals Inc. | Deuterated darunavir |
| EP2877474B1 (en) * | 2012-07-24 | 2020-11-04 | Laurus Labs Limited | A process for preparation of darunavir |
| KR102506813B1 (ko) * | 2016-11-17 | 2023-03-06 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 간소화된 다루나비르 제조 절차 |
-
2017
- 2017-11-16 KR KR1020197016468A patent/KR102506813B1/ko active IP Right Grant
- 2017-11-16 WO PCT/EP2017/079375 patent/WO2018091559A1/en unknown
- 2017-11-16 CA CA3041393A patent/CA3041393A1/en active Pending
- 2017-11-16 AU AU2017361799A patent/AU2017361799B2/en active Active
- 2017-11-16 ES ES17797375T patent/ES2854003T3/es active Active
- 2017-11-16 CN CN201780070998.4A patent/CN110291091B/zh active Active
- 2017-11-16 JP JP2019526325A patent/JP7035049B2/ja active Active
- 2017-11-16 MX MX2019005722A patent/MX2019005722A/es unknown
- 2017-11-16 HU HUE17797375A patent/HUE053006T2/hu unknown
- 2017-11-16 DK DK17797375.7T patent/DK3541819T3/da active
- 2017-11-16 US US16/461,754 patent/US10774088B2/en active Active
- 2017-11-16 SI SI201730574T patent/SI3541819T1/sl unknown
- 2017-11-16 PL PL17797375T patent/PL3541819T3/pl unknown
- 2017-11-16 PT PT177973757T patent/PT3541819T/pt unknown
- 2017-11-16 RU RU2019118298A patent/RU2745740C2/ru active
- 2017-11-16 EP EP17797375.7A patent/EP3541819B1/en active Active
- 2017-11-16 BR BR112019009675A patent/BR112019009675A2/pt active Search and Examination
-
2020
- 2020-09-14 US US17/020,627 patent/US11427599B2/en active Active
- 2020-12-14 HR HRP20202000TT patent/HRP20202000T1/hr unknown
-
2021
- 2021-02-11 CY CY20211100116T patent/CY1123830T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1123830T1 (el) | 2022-05-27 |
| US20210139495A1 (en) | 2021-05-13 |
| US11427599B2 (en) | 2022-08-30 |
| US20190359625A1 (en) | 2019-11-28 |
| CN110291091A (zh) | 2019-09-27 |
| EP3541819A1 (en) | 2019-09-25 |
| BR112019009675A2 (pt) | 2019-08-06 |
| AU2017361799B2 (en) | 2021-05-20 |
| HRP20202000T1 (hr) | 2021-02-19 |
| PT3541819T (pt) | 2021-02-24 |
| RU2745740C2 (ru) | 2021-03-31 |
| DK3541819T3 (da) | 2021-02-22 |
| AU2017361799A1 (en) | 2019-05-02 |
| US10774088B2 (en) | 2020-09-15 |
| KR20190082874A (ko) | 2019-07-10 |
| JP7035049B2 (ja) | 2022-03-14 |
| HUE053006T2 (hu) | 2021-06-28 |
| WO2018091559A1 (en) | 2018-05-24 |
| SI3541819T1 (sl) | 2021-02-26 |
| KR102506813B1 (ko) | 2023-03-06 |
| JP2019535725A (ja) | 2019-12-12 |
| RU2019118298A (ru) | 2020-12-18 |
| EP3541819B1 (en) | 2020-12-09 |
| CA3041393A1 (en) | 2018-05-24 |
| RU2019118298A3 (es) | 2021-02-05 |
| ES2854003T3 (es) | 2021-09-20 |
| PL3541819T3 (pl) | 2021-06-14 |
| CN110291091B (zh) | 2022-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR119702A2 (es) | Proceso para la preparación de (1s,2r)-3-[[(4-aminofenil)sulfonil](isobutil)amino]-1-bencil-2-hidroxipropilcarbamato de (3r,3as,6ar)-hexahidrofuro[2,3-b]furan-3-ilo | |
| CL2021003547A1 (es) | Proteínas de fusión fc heterodiméricas il15/il15ra (divisional de la solicitud no. 201901000) | |
| WO2017123763A8 (en) | Processes for the preparation of 2,5-furandicarboxylic acid and intermediates and derivatives thereof | |
| WO2017100305A3 (en) | Composition of antibody construct-agonist conjugates and methods of use thereof | |
| AR096762A1 (es) | Oligomerización de corrientes de c₄ con muy bajo contenido de 1-buteno | |
| RU2009121792A (ru) | СПОСОБЫ ПОЛУЧЕНИЯ ГЕКСАГИДРОФУРО[2,3-b] ФУРАН-3-ОЛА | |
| AR095340A1 (es) | Compuestos y sus usos para la modulación de hemoglobina | |
| BR112014016185A8 (pt) | Processo para a produção de uma mistura de ácido 2,4-furandicarboxílico e ácido 2,5-furandicarboxílico | |
| NZ600994A (en) | Darunavir polymorph and process for preparation thereof | |
| EA201190205A1 (ru) | ПОЛЕЗНЫЕ ФАРМАЦЕВТИЧЕСКИЕ СОЛИ 7-[(3R,4R)-3-ГИДРОКСИ-4-ГИДРОКСИМЕТИЛПИРРОЛИДИН-1-ИЛМЕТИЛ]-3,5-ДИГИДРОПИРРОЛО[3,2-d]ПИРИМИДИН-4-ОНА | |
| WO2014178078A3 (en) | Novel cloning, expression & purification method for the preparation of ranibizumab | |
| WO2011051978A3 (en) | A novel process for preparation of darunavir and darunavir ethanolate of fine particle size | |
| ME01059B (me) | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata | |
| AU2013348091A8 (en) | Synthesis of spirocyclic isoxazoline derivatives | |
| MX2022009886A (es) | Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. | |
| MX2019005722A (es) | Procedimiento simplificado para la preparacion de darunavir. | |
| BR112018013882A2 (pt) | moduladores alostéricos positivos do receptor muscarínico de acetilcolina m4 | |
| WO2015120111A3 (en) | Expedient synthesis of sitagliptin | |
| PE20211110A1 (es) | Distrofinas miniaturizadas y usos de las mismas | |
| WO2017029553A8 (en) | Methods, cells and reagents for production of isoprene, derivatives and intermediates thereof | |
| WO2014195929A3 (en) | Process for the preparation of halogenated carboxylic anhydrides | |
| EP3313847A4 (en) | PROCESS FOR PREPARING (3R, 3AS, 6AR) HEXAHYDROFURO [2,3-B] FURAN-3-YL ESTER OF [(1S, 2R) -3 - [[(4-AMINOPHENYL) SULFONYL] (2-METHYLPROPYL) ACID ) AMINO] -2-HYDROXY-1- (PHENYLMETHYL) PROPYL] -CARBAMIC AND ITS AMORPHOUS FORM | |
| CL2013002832A1 (es) | Compuestos derivados del acido 7-(heteroaril-amino)-6,7,8,9-tetrahidropirido[1,2-a]indol acetico, moduladores del receptor de prostaglandina d2; composicion farmaceutica; y uso en la prevencion y el tratamiento de enfermedades alergicas e inmunes tales como asma. | |
| WO2017021974A8 (en) | Novel and synergistic composition of lecithin and lysolecithin for improving bioavailability and solubility of hydrophobic compounds and extracts | |
| WO2016084100A3 (en) | Novel and efficient method for large scale synthesis of romidepsin |