MX2018015068A - Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos. - Google Patents

Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos.

Info

Publication number
MX2018015068A
MX2018015068A MX2018015068A MX2018015068A MX2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A MX 2018015068 A MX2018015068 A MX 2018015068A
Authority
MX
Mexico
Prior art keywords
basal insulin
acid bearing
injectable solution
carboxylate charges
bearing carboxylate
Prior art date
Application number
MX2018015068A
Other languages
English (en)
Inventor
Soula Olivier
Geissler Alexandre
Charvet Richard
LAAGE Ségolène
Original Assignee
Adocia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adocia filed Critical Adocia
Publication of MX2018015068A publication Critical patent/MX2018015068A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se relaciona con composiciones estables físicamente en la forma de una solución acuosa inyectable, cuyo pH es de 6.0 a 8.0, que comprende por lo menos: a) una insulina basal cuyo punto isoeléctrico (pI) es de 5.8 a 8.5, b) un co-poliamino ácido que porta cargas de carboxilato y por lo menos un radical hidrofóbico.
MX2018015068A 2016-06-07 2017-06-07 Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos. MX2018015068A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1655222A FR3052072A1 (fr) 2016-06-07 2016-06-07 Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
PCT/EP2017/063865 WO2017211903A1 (fr) 2016-06-07 2017-06-07 Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes

Publications (1)

Publication Number Publication Date
MX2018015068A true MX2018015068A (es) 2019-05-09

Family

ID=57348773

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018015068A MX2018015068A (es) 2016-06-07 2017-06-07 Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5 y co-poliamino acido que porta cargas de carboxilatos y radicales hidrofobicos.
MX2018015067A MX2018015067A (es) 2016-06-07 2017-06-07 Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5, una insulina prandial y/o una hormona gastrointestinal y un co-poliamino acido que porta cargas de carboxilatos y de radicales hidrofobicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018015067A MX2018015067A (es) 2016-06-07 2017-06-07 Solucion inyectable a ph 7 que comprende por lo menos una insulina basal cuyo pi esta comprendido entre 5.8 y 8.5, una insulina prandial y/o una hormona gastrointestinal y un co-poliamino acido que porta cargas de carboxilatos y de radicales hidrofobicos.

Country Status (12)

Country Link
US (2) US10383920B2 (es)
EP (2) EP3463293B1 (es)
JP (1) JP2019517555A (es)
CN (2) CN109379888B (es)
BR (2) BR112018075140A2 (es)
EA (2) EA039333B1 (es)
FR (1) FR3052072A1 (es)
MX (2) MX2018015068A (es)
PH (1) PH12018502558A1 (es)
SA (2) SA518400588B1 (es)
SG (2) SG11201810937WA (es)
WO (2) WO2017211903A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3070264A1 (fr) * 2017-08-24 2019-03-01 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
FR3083089A1 (fr) * 2018-06-29 2020-01-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
CN111836616B (zh) 2017-12-07 2024-01-16 阿道恰公司 包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的ph 7为7的可注射溶液
CN111683674A (zh) 2017-12-07 2020-09-18 阿道恰公司 包含胰淀素、胰淀素激动剂受体或胰淀素类似物和共聚氨基酸的可注射水溶液形式的组合物
MX2020005913A (es) 2017-12-07 2020-10-19 Adocia Solución inyectable a ph 7 que comprende al menos una insulina basal que tiene un pi de entre 5.8 y 8.5 y un copoliaminoácido con cargas de carboxilato y radicales hidrofóbicos.
KR20200106891A (ko) 2017-12-07 2020-09-15 아도시아 pI가 5.8 내지 8.5인 적어도 1종의 기저 인슐린, 및 카복실산염 전하 및 소수성 라디칼을 보유하는 코-폴리아미노산을 포함하는 pH 7의 주사용 용액
US11173109B2 (en) 2017-12-07 2021-11-16 Adocia Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog and a co-polyamino acid
US20190275108A1 (en) * 2017-12-07 2019-09-12 Adocia Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analogue and a co-polyamino acid
FR3083086A1 (fr) * 2018-06-29 2020-01-03 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide
FR3067247A1 (fr) * 2018-06-07 2018-12-14 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide
WO2019243628A1 (fr) * 2018-06-22 2019-12-26 Adocia Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal
FR3084586B1 (fr) * 2018-08-03 2020-11-06 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes
FR3084585B1 (fr) * 2018-08-03 2020-11-06 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un compose amphiphile porteur de radicaux hydrophobes
US20200179489A1 (en) * 2018-12-07 2020-06-11 Adocia Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol
WO2020115334A1 (fr) * 2018-12-07 2020-06-11 Adocia Procede de preparation d'une composition stable sous forme d'une solution aqueuse injectable
WO2020245470A1 (fr) 2019-06-07 2020-12-10 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5, du liraglutide et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes

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Publication number Priority date Publication date Assignee Title
US4826818A (en) 1983-10-26 1989-05-02 Kanebo Ltd. Proteinaceous emulsifier, process for preparing same and emulsion type cosmetic compositions containing same
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
FR2801226B1 (fr) 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
EP1545460A4 (en) 2001-12-20 2005-11-16 Lilly Co Eli INSULIN MOLECULE WITH TEMPORARY EFFECT
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
EP1620465A2 (en) 2003-04-29 2006-02-01 Eli Lilly And Company Insulin analogs having protracted time action
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
FR2915683B1 (fr) * 2007-05-03 2009-08-07 Flamel Technologies Sa Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
AU2012293463B2 (en) * 2011-08-10 2016-08-04 Adocia Injectable solution of at least one type of basal insulin
BR112014016889A8 (pt) * 2012-01-09 2017-07-04 Adocia composição sob a forma de uma solução aquosa injetável, sujo ph está compreendido entre 6,0 e 8,0 e, formulação de dose unitária com ph compreendido entre 7 e 7,8
FR2985429B1 (fr) 2012-01-09 2016-07-29 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue obtenu par un procede de polymerisation controle
FR3001896B1 (fr) 2013-02-12 2015-07-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le point isolectrique est compris entre 5,8 et 8,5 et un polymere anionique hydrophobise
FR3001895B1 (fr) 2013-02-12 2015-07-03 Adocia Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes

Also Published As

Publication number Publication date
BR112018075151A2 (pt) 2019-03-26
SA518400596B1 (ar) 2022-03-16
CN109640953B (zh) 2021-10-29
CN109640953A (zh) 2019-04-16
US20170348396A1 (en) 2017-12-07
EA039333B1 (ru) 2022-01-14
SA518400588B1 (ar) 2022-03-07
US10548952B2 (en) 2020-02-04
MX2018015067A (es) 2019-05-09
CN109379888B (zh) 2021-10-29
SG11201810935SA (en) 2019-01-30
EP3463292B1 (fr) 2020-08-05
CN109379888A (zh) 2019-02-22
PH12018502558A1 (en) 2019-10-14
FR3052072A1 (fr) 2017-12-08
WO2017211903A1 (fr) 2017-12-14
EA201892737A1 (ru) 2019-05-31
EA201892736A1 (ru) 2019-05-31
EA039363B1 (ru) 2022-01-18
BR112018075140A2 (pt) 2019-03-26
US10383920B2 (en) 2019-08-20
US20170348423A1 (en) 2017-12-07
WO2017211916A1 (fr) 2017-12-14
SG11201810937WA (en) 2019-01-30
EP3463292A1 (fr) 2019-04-10
JP2019517555A (ja) 2019-06-24
EP3463293B1 (fr) 2021-05-12
EP3463293A1 (fr) 2019-04-10

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