SG11201810935SA - Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid bearing carboxylate charges and hydrophobic radicals - Google Patents
Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid bearing carboxylate charges and hydrophobic radicalsInfo
- Publication number
- SG11201810935SA SG11201810935SA SG11201810935SA SG11201810935SA SG11201810935SA SG 11201810935S A SG11201810935S A SG 11201810935SA SG 11201810935S A SG11201810935S A SG 11201810935SA SG 11201810935S A SG11201810935S A SG 11201810935SA SG 11201810935S A SG11201810935S A SG 11201810935SA
- Authority
- SG
- Singapore
- Prior art keywords
- basal insulin
- acid bearing
- carboxylate charges
- bearing carboxylate
- injectable solution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN HAVING A PI OF BETWEEN 5.8 AND 8.5 AND A COPOLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS [0001] The invention relates to physically stable compositions in the form of an injectable aqueous solution, the pH of which is from 6.0 to 8.0, comprising at least: a) a basal insulin of which the isoelectric point (pI) is from 5.8 to 8.5, and b) a co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1655222A FR3052072A1 (en) | 2016-06-07 | 2016-06-07 | PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WITH A PI BETWEEN 5.8 AND 8.5 AND A CO-POLYAMINOACIDE CARRYING CARBOXYLATE LOADS AND HYDROPHOBIC RADICALS |
PCT/EP2017/063865 WO2017211903A1 (en) | 2016-06-07 | 2017-06-07 | Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid bearing carboxylate charges and hydrophobic radicals |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201810935SA true SG11201810935SA (en) | 2019-01-30 |
Family
ID=57348773
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201810937WA SG11201810937WA (en) | 2016-06-07 | 2017-06-07 | Injectable solution at ph 7, comprising at least one basal insulin whose pi is between 5.8 and 8.5, a prandial insulin and/or a gastrointestinal hormone, and a copolyamino acid bearing carboxylate charges and hydrophobic radicals |
SG11201810935SA SG11201810935SA (en) | 2016-06-07 | 2017-06-07 | Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid bearing carboxylate charges and hydrophobic radicals |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201810937WA SG11201810937WA (en) | 2016-06-07 | 2017-06-07 | Injectable solution at ph 7, comprising at least one basal insulin whose pi is between 5.8 and 8.5, a prandial insulin and/or a gastrointestinal hormone, and a copolyamino acid bearing carboxylate charges and hydrophobic radicals |
Country Status (12)
Country | Link |
---|---|
US (2) | US10548952B2 (en) |
EP (2) | EP3463293B1 (en) |
JP (1) | JP2019517555A (en) |
CN (2) | CN109640953B (en) |
BR (2) | BR112018075140A2 (en) |
EA (2) | EA039363B1 (en) |
FR (1) | FR3052072A1 (en) |
MX (2) | MX2018015068A (en) |
PH (1) | PH12018502558A1 (en) |
SA (2) | SA518400588B1 (en) |
SG (2) | SG11201810937WA (en) |
WO (2) | WO2017211916A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3070264A1 (en) * | 2017-08-24 | 2019-03-01 | Adocia | PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN INCLUDING AN INHIBIT OF 5.8 TO 8.5 AND A CO-POLYAMINOACIDE CARBOXYLATE AND HYDROPHOBIC RADICAL CARRIERS |
FR3083089A1 (en) * | 2018-06-29 | 2020-01-03 | Adocia | PH 7 INJECTION SOLUTION COMPRISING AT LEAST ONE BASAL INSULIN WITH A PI BETWEEN 5.8 AND 8.5 AND A CO-POLYAMINOACID CARRYING CARBOXYLATES AND HYDROPHOBIC RADICALS |
MX2020005913A (en) | 2017-12-07 | 2020-10-19 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin having a pi of between 5.8 and 8.5 and a copolyamino acid carrying carboxylate charges and hydrophobic radicals. |
FR3083086A1 (en) * | 2018-06-29 | 2020-01-03 | Adocia | COMPOSITIONS IN THE FORM OF AN AQUEOUS INJECTION SOLUTION COMPRISING AMYLINE, AN AMYLINE RECEPTOR AGONIST OR AN AMYLINE ANALOG AND A CO-POLYAMINOACID |
US20190275108A1 (en) * | 2017-12-07 | 2019-09-12 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analogue and a co-polyamino acid |
KR20200106892A (en) | 2017-12-07 | 2020-09-15 | 아도시아 | A solution for injection at pH 7 comprising at least one basal insulin with a pI of 5.8 to 8.5, and a co-polyamino acid bearing a carboxylate charge and a hydrophobic radical |
US20190216931A1 (en) | 2017-12-07 | 2019-07-18 | Adocia | Injectable ph 7 solution comprising at least one basal insulin having a pi from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals |
EP3740195A1 (en) * | 2017-12-07 | 2020-11-25 | Adocia | Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog and a copolyamino acid |
BR112020011479A2 (en) | 2017-12-07 | 2020-11-17 | Adocia | compositions in the form of an aqueous solution for injection characterized by the fact that it comprises amylin, an amylin receptor agonist or an amylin analog and a co-polyamino acid |
FR3067247A1 (en) * | 2018-06-07 | 2018-12-14 | Adocia | COMPOSITIONS IN THE FORM OF AN INJECTION AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A CO-POLYAMINOACID |
WO2019243628A1 (en) * | 2018-06-22 | 2019-12-26 | Adocia | Injectable composition with a ph of 7 comprising a co-polyaminoacid bearing carboxylate charges and hydrophobic radicals and at least one basal insulin having at least a prandial effect and a basal effect |
FR3084585B1 (en) * | 2018-08-03 | 2020-11-06 | Adocia | SOLUTION FOR INJECTION AT PH 7 INCLUDING AT LEAST ONE BASAL INSULIN WHOSE PI IS BETWEEN 5.8 AND 8.5 AND AN AMPHIPHILIC COMPOUND CARRIER OF HYDROPHOBIC RADICALS |
FR3084586B1 (en) * | 2018-08-03 | 2020-11-06 | Adocia | COMPOSITIONS IN THE FORM OF AN AQUEOUS SOLUTION FOR INJECTION CONSISTING OF AMYLINE, AN AMYLINE RECEPTOR AGONIST OR ANALOGUE OF AMYLINE AND AN AMPHIPHILIC COMPOUND CARRIER OF HYDROPHOBIC RADICALS |
WO2020115334A1 (en) * | 2018-12-07 | 2020-06-11 | Adocia | Method for preparing a stable composition in the form of an injectable aqueous solution |
US20200179489A1 (en) * | 2018-12-07 | 2020-06-11 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol |
WO2020245470A1 (en) | 2019-06-07 | 2020-12-10 | Adocia | Injectable solution at ph 7 containing at least one basal insulin, the pi of which is between 5.8 and 8.5, liraglutide, and a copolyamino acid carrying carboxylate charges and hydrophobic radicals |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826818A (en) | 1983-10-26 | 1989-05-02 | Kanebo Ltd. | Proteinaceous emulsifier, process for preparing same and emulsion type cosmetic compositions containing same |
DE3837825A1 (en) | 1988-11-08 | 1990-05-10 | Hoechst Ag | NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
FR2801226B1 (en) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | COLLOIDAL SUSPENSION OF SUBMICRONIC PARTICLES FOR VECTORIZATION OF ACTIVE INGREDIENTS AND METHOD OF PREPARATION |
IL161848A0 (en) | 2001-12-20 | 2005-11-20 | Lilly Co Eli | Insulin moldecule having protracted time action |
FR2840614B1 (en) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | POLYAMINOACIDS FUNCTIONALIZED BY ALPHA-TOCOPHEROL AND THEIR PARTICULARLY THERAPEUTIC APPLICATIONS |
WO2004096854A2 (en) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
FR2862535B1 (en) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | PHARMACEUTICAL FORMULATIONS FOR PROLONGED RELEASE OF INTERLEUKINS AND THEIR THERAPEUTIC APPLICATIONS |
FR2915683B1 (en) * | 2007-05-03 | 2009-08-07 | Flamel Technologies Sa | SELF-PRECIPITANT PHARMACEUTICAL FORMULATIONS FOR MODIFIED RELEASE OF ACTIVE INGREDIENTS |
US9089476B2 (en) * | 2011-08-10 | 2015-07-28 | Adocia | Injectable solution at pH 7 comprising at least one basal insulin whose PI is between 5.8 and 8.5 |
FR2985429B1 (en) | 2012-01-09 | 2016-07-29 | Adocia | PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WITH A PI BETWEEN 5.8 AND 8.5 AND A SUBSTITUTED POLYAMINOACID OBTAINED BY A CONTROLLED POLYMERIZATION PROCESS |
EP2814461B1 (en) * | 2012-01-09 | 2019-07-24 | Adocia | Injectable solution having a ph of 7 and including at least basal insulin, the pi of which is between 5.8 and 8.5, and a substituted co-poly(amino acid) |
FR3001896B1 (en) | 2013-02-12 | 2015-07-03 | Adocia | PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WHERE THE ISO-ELECTRIC POINT IS BETWEEN 5.8 AND 8.5 AND A HYDROPHOBIC ANIONIC POLYMER |
FR3001895B1 (en) | 2013-02-12 | 2015-07-03 | Adocia | PH7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WHERE THE ISOELECTRIC POINT IS INCLUDED IN 5.8 AND 8.5 AND AN ANIONIC COMPOUND CARRYING CARBOXYLATE LOADS AND HYDROPHOBIC RADICALS |
-
2016
- 2016-06-07 FR FR1655222A patent/FR3052072A1/en not_active Withdrawn
-
2017
- 2017-06-07 EP EP17727910.6A patent/EP3463293B1/en active Active
- 2017-06-07 SG SG11201810937WA patent/SG11201810937WA/en unknown
- 2017-06-07 SG SG11201810935SA patent/SG11201810935SA/en unknown
- 2017-06-07 WO PCT/EP2017/063886 patent/WO2017211916A1/en unknown
- 2017-06-07 BR BR112018075140-5A patent/BR112018075140A2/en not_active Application Discontinuation
- 2017-06-07 WO PCT/EP2017/063865 patent/WO2017211903A1/en unknown
- 2017-06-07 MX MX2018015068A patent/MX2018015068A/en unknown
- 2017-06-07 EP EP17727906.4A patent/EP3463292B1/en active Active
- 2017-06-07 EA EA201892737A patent/EA039363B1/en unknown
- 2017-06-07 EA EA201892736A patent/EA039333B1/en unknown
- 2017-06-07 MX MX2018015067A patent/MX2018015067A/en unknown
- 2017-06-07 CN CN201780047889.0A patent/CN109640953B/en active Active
- 2017-06-07 BR BR112018075151-0A patent/BR112018075151A2/en not_active Application Discontinuation
- 2017-06-07 CN CN201780035320.2A patent/CN109379888B/en active Active
- 2017-06-07 US US15/616,470 patent/US10548952B2/en active Active
- 2017-06-07 US US15/616,128 patent/US10383920B2/en active Active
- 2017-06-07 JP JP2018564355A patent/JP2019517555A/en active Pending
-
2018
- 2018-12-04 SA SA518400588A patent/SA518400588B1/en unknown
- 2018-12-04 PH PH12018502558A patent/PH12018502558A1/en unknown
- 2018-12-05 SA SA518400596A patent/SA518400596B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3463292A1 (en) | 2019-04-10 |
SA518400596B1 (en) | 2022-03-16 |
EP3463293B1 (en) | 2021-05-12 |
WO2017211903A1 (en) | 2017-12-14 |
JP2019517555A (en) | 2019-06-24 |
US20170348396A1 (en) | 2017-12-07 |
CN109640953B (en) | 2021-10-29 |
FR3052072A1 (en) | 2017-12-08 |
CN109640953A (en) | 2019-04-16 |
PH12018502558A1 (en) | 2019-10-14 |
US10383920B2 (en) | 2019-08-20 |
CN109379888B (en) | 2021-10-29 |
MX2018015067A (en) | 2019-05-09 |
EP3463293A1 (en) | 2019-04-10 |
EA201892737A1 (en) | 2019-05-31 |
BR112018075140A2 (en) | 2019-03-26 |
WO2017211916A1 (en) | 2017-12-14 |
CN109379888A (en) | 2019-02-22 |
US10548952B2 (en) | 2020-02-04 |
MX2018015068A (en) | 2019-05-09 |
EP3463292B1 (en) | 2020-08-05 |
EA039363B1 (en) | 2022-01-18 |
EA039333B1 (en) | 2022-01-14 |
SA518400588B1 (en) | 2022-03-07 |
SG11201810937WA (en) | 2019-01-30 |
US20170348423A1 (en) | 2017-12-07 |
EA201892736A1 (en) | 2019-05-31 |
BR112018075151A2 (en) | 2019-03-26 |
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