MX2018011306A - Vector multimodal para infeccion de celulas dentriticas. - Google Patents
Vector multimodal para infeccion de celulas dentriticas.Info
- Publication number
- MX2018011306A MX2018011306A MX2018011306A MX2018011306A MX2018011306A MX 2018011306 A MX2018011306 A MX 2018011306A MX 2018011306 A MX2018011306 A MX 2018011306A MX 2018011306 A MX2018011306 A MX 2018011306A MX 2018011306 A MX2018011306 A MX 2018011306A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- dendritic cell
- cancer
- cell infection
- viral nucleic
- Prior art date
Links
- 210000004443 dendritic cell Anatomy 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 abstract 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 abstract 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 abstract 1
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 1
- 102100022339 Integrin alpha-L Human genes 0.000 abstract 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1777—Integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Los virus recombinantes y acidos nucleicos virales se contemplan que proporcionan a la celula infectada varias moleculas reguladoras que estimulan la actividad de la celula T y celula NK y que suprime la inhibicion de la actividad de la celula T y celula NK. Mas preferiblemente, el virus y acido nucleico viral incluira ademas una secuencia asociada al cancer humano, y especialmente una secuencia que codifica una pluralidad de antigenos asociados al cancer, antigenos especificos al cancer, y/o neoantigenos especificos al tumor o al paciente. Especialmente las moléculas reguladoras especificas incluyen CD80 (B7.1), CD86 (B7.2), CD54 (ICAM-1/BB2), CD11 (LFA-1), y un inhibidor de CTLA-4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662310551P | 2016-03-18 | 2016-03-18 | |
US201662313596P | 2016-03-25 | 2016-03-25 | |
PCT/US2017/023117 WO2017161360A2 (en) | 2016-03-18 | 2017-03-20 | Multimodal vector for dendritic cell infection |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018011306A true MX2018011306A (es) | 2019-08-16 |
Family
ID=59850551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018011306A MX2018011306A (es) | 2016-03-18 | 2017-03-20 | Vector multimodal para infeccion de celulas dentriticas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210198689A1 (es) |
EP (1) | EP3430148A4 (es) |
JP (1) | JP2019508044A (es) |
KR (1) | KR20180118198A (es) |
CN (1) | CN109312364A (es) |
AU (1) | AU2017233072B2 (es) |
CA (1) | CA3016389A1 (es) |
IL (1) | IL261812A (es) |
MX (1) | MX2018011306A (es) |
SG (1) | SG11201808058PA (es) |
WO (1) | WO2017161360A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201414021D0 (en) | 2014-08-07 | 2014-09-24 | Nascient Ltd | Biological materials and uses thereof |
DK3288573T3 (da) | 2015-04-30 | 2020-03-16 | Psioxus Therapeutics Ltd | Onkolytisk adenovirus, der koder for et b7-protein |
JP6533011B2 (ja) | 2015-08-25 | 2019-06-19 | ナントミクス,エルエルシー | 高正確度変異体コールのためのシステムおよび方法 |
MY193281A (en) | 2015-12-17 | 2022-09-30 | Psioxus Therapeutics Ltd | Group b adenovirus encoding an anti-tcr-complex antibody or fragment |
AU2017290803A1 (en) | 2016-06-30 | 2019-01-24 | Nant Holdings Ip, Llc | Nant cancer vaccine |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
WO2018041838A1 (en) | 2016-08-29 | 2018-03-08 | Psioxus Therapeutics Limited | Adenovirus armed with bispecific t cell engager (bite) |
EP3630143B1 (en) | 2017-06-01 | 2023-06-07 | Akamis Bio Limited | Oncolytic virus and method |
GB201801614D0 (en) | 2018-01-31 | 2018-03-14 | Psioxus Therapeutics Ltd | Formulation |
US11823773B2 (en) | 2018-04-13 | 2023-11-21 | Nant Holdings Ip, Llc | Nant cancer vaccine strategies |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE361988T1 (de) * | 1998-12-09 | 2007-06-15 | Us Gov Health & Human Serv | Recombinanter vector, welcher mehrere kostimulatorische moleküle exprimiert und dessen verwenden |
AU2002307145B2 (en) * | 2001-04-05 | 2007-11-29 | The John Hopkins University | Chimeric vaccines |
WO2003039592A2 (de) * | 2001-11-09 | 2003-05-15 | Medigene Aktiengesellschaft | Zelluläre impfstoffe mit adjuvanzien |
WO2005035773A2 (en) * | 2003-10-08 | 2005-04-21 | Sanofi Pasteur, Inc. | Modified cea /b7 vector |
US20040156828A1 (en) * | 2003-01-07 | 2004-08-12 | Ruian Xu | Adeno-associated virus mediated B7.1 vaccination synergizes with angiostatin to eradicate disseminated liver metastatic cancers |
WO2006108241A1 (en) * | 2005-04-14 | 2006-10-19 | The University Of Queensland | Immunomodulating compositions and uses therefor |
EP2619312A1 (en) * | 2010-09-24 | 2013-07-31 | Oncos Therapeutics Oy | Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies |
PT2751279T (pt) * | 2011-08-31 | 2017-12-29 | St Jude Children`S Res Hospital | Métodos e composições para detetar o nível de atividade de exocitose lisossomal e métodos de utilização |
CN102533859A (zh) * | 2012-01-12 | 2012-07-04 | 中国人民解放军第二军医大学 | 携带可诱导性共刺激分子基因的腺病毒载体及其构建方法与应用 |
WO2014066443A1 (en) * | 2012-10-23 | 2014-05-01 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
KR102006527B1 (ko) * | 2013-11-01 | 2019-08-02 | 화이자 인코포레이티드 | 전립선-연관 항원의 발현을 위한 벡터 |
JP6535337B2 (ja) * | 2013-11-05 | 2019-06-26 | バヴァリアン・ノルディック・アクティーゼルスカブ | 腫瘍抗原を発現するポックスウイルスならびに免疫チェックポイント阻害剤のアンタゴニスト及び/またはアゴニストにより癌を治療するための組み合わせ療法 |
AU2014368898B2 (en) * | 2013-12-20 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Combination therapy with neoantigen vaccine |
US11028143B2 (en) * | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
GB201406608D0 (en) * | 2014-04-12 | 2014-05-28 | Psioxus Therapeutics Ltd | Virus |
IL248507B (en) * | 2014-05-13 | 2022-07-01 | Bavarian Nordic As | Combined therapy for the treatment of cancer with a recombinant focovirus that expresses an antigen and an antagonist or agonist for an immune control molecule |
-
2017
- 2017-03-20 SG SG11201808058PA patent/SG11201808058PA/en unknown
- 2017-03-20 CA CA3016389A patent/CA3016389A1/en not_active Abandoned
- 2017-03-20 EP EP17767693.9A patent/EP3430148A4/en not_active Withdrawn
- 2017-03-20 MX MX2018011306A patent/MX2018011306A/es unknown
- 2017-03-20 KR KR1020187028404A patent/KR20180118198A/ko not_active Application Discontinuation
- 2017-03-20 JP JP2018546653A patent/JP2019508044A/ja active Pending
- 2017-03-20 WO PCT/US2017/023117 patent/WO2017161360A2/en active Application Filing
- 2017-03-20 CN CN201780017523.9A patent/CN109312364A/zh active Pending
- 2017-03-20 AU AU2017233072A patent/AU2017233072B2/en not_active Ceased
- 2017-03-20 US US16/081,014 patent/US20210198689A1/en not_active Abandoned
-
2018
- 2018-09-16 IL IL261812A patent/IL261812A/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201808058PA (en) | 2018-10-30 |
EP3430148A2 (en) | 2019-01-23 |
WO2017161360A4 (en) | 2017-11-16 |
IL261812A (en) | 2018-10-31 |
WO2017161360A2 (en) | 2017-09-21 |
WO2017161360A3 (en) | 2017-10-26 |
CN109312364A (zh) | 2019-02-05 |
AU2017233072B2 (en) | 2020-12-24 |
US20210198689A1 (en) | 2021-07-01 |
CA3016389A1 (en) | 2017-09-21 |
EP3430148A4 (en) | 2020-01-01 |
KR20180118198A (ko) | 2018-10-30 |
JP2019508044A (ja) | 2019-03-28 |
AU2017233072A1 (en) | 2018-09-13 |
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