MX2018010923A - Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5. - Google Patents

Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5.

Info

Publication number
MX2018010923A
MX2018010923A MX2018010923A MX2018010923A MX2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A MX 2018010923 A MX2018010923 A MX 2018010923A
Authority
MX
Mexico
Prior art keywords
nucleoside analogues
substituted nucleoside
prmt5 inhibitors
compounds
present
Prior art date
Application number
MX2018010923A
Other languages
English (en)
Inventor
Meerpoel Lieven
Arnodus Hendrika Joseph Gilissen Ronaldus
Bert Griet Schepens Wim
BREHMER Dirk
BEKE Lijs
Charles LAWSON Edward
Pande Vineet
Sun Weimei
Jean- Claude Berthelot Didier
Boeckx An
Stanislas Marcella Diels Gaston
Cornelis Bernardus Catharina Paradé Marcus
Christopher Shook Brian
Wilhelmus John F Thuring Johannes
Viellevoye Marcel
Wu Tongfei
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2017/054324 external-priority patent/WO2017153186A1/en
Publication of MX2018010923A publication Critical patent/MX2018010923A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid

Abstract

La presente invencion se refiere a nuevos analogos de nucleosidos sustituidos de Formula (I) (ver fórmula) en donde las variables tienen el significado definido en las reivindicaciones. Los compuestos de acuerdo con la presente invencion son utiles como inhibidores de PRMT5. La invencion se refiere ademas a composiciones farmaceuticas que comprenden dichos compuestos como principio activo, asi como tambien al uso de dichos compuestos como un medicamento.
MX2018010923A 2016-03-10 2017-02-24 Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5. MX2018010923A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306222P 2016-03-10 2016-03-10
EP16162731 2016-03-30
PCT/EP2017/054324 WO2017153186A1 (en) 2016-03-10 2017-02-24 Substituted nucleoside analogues for use as prmt5 inhibitors

Publications (1)

Publication Number Publication Date
MX2018010923A true MX2018010923A (es) 2019-02-13

Family

ID=65443152

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010923A MX2018010923A (es) 2016-03-10 2017-02-24 Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5.

Country Status (11)

Country Link
US (1) US10898504B2 (es)
JP (1) JP6909799B2 (es)
BR (1) BR112018067789B1 (es)
EA (1) EA201892031A1 (es)
ES (1) ES2891320T3 (es)
MA (1) MA43671A (es)
MX (1) MX2018010923A (es)
PH (1) PH12018501895A1 (es)
TN (1) TN2018000310A1 (es)
UA (1) UA123637C2 (es)
ZA (1) ZA201806016B (es)

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AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
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US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
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EP1844062A2 (en) 2005-01-21 2007-10-17 Methylgene, Inc. Inhibitors of dna methyltransferase
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WO2010039548A2 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
AU2010330823A1 (en) 2009-12-18 2012-07-05 Joslin Diabetes Center, Inc. Beta-cell replication promoting compounds and methods of their use
AU2011341441A1 (en) 2010-12-03 2013-06-20 Epizyme, Inc. Modulators of histone methyltransferase, and methods of use thereof
RU2013130253A (ru) 2010-12-03 2015-01-10 Эпизайм, Инк. 7-деазапуриновые регуляторы метилтрансферазы гистонов и способы их применения
MX2013006951A (es) 2010-12-16 2013-10-03 Abbvie Inc Compuestos antivirales.
EP2694524B1 (en) 2011-04-04 2016-05-18 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services 2'-o-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
WO2014035140A2 (en) 2012-08-30 2014-03-06 Kainos Medicine, Inc. Compounds and compositions for modulating histone methyltransferase activity
US20140100184A1 (en) 2012-08-31 2014-04-10 Baylor College Of Medicine Selective inhibitors of histone methyltransferase dot1l
EP2935243B1 (en) 2012-12-21 2018-03-14 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
HUE040323T2 (hu) 2012-12-21 2019-02-28 Epizyme Inc PRMT5-inhibitorok és alkalmazásaik
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP6510539B2 (ja) 2014-01-09 2019-05-08 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン 置換ベンゾオキサジン及び関連化合物
US20170198006A1 (en) 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
BR112017017396A2 (pt) 2015-02-24 2018-04-03 Pfizer derivados substituídos de nucleosídeos substituídos úteis como agentes anticancerígenos
TW202321249A (zh) * 2015-08-26 2023-06-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６－６雙環芳香環取代之核苷類似物
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WO2017153186A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as prmt5 inhibitors
EA201990851A1 (ru) 2017-02-24 2019-09-30 Янссен Фармацевтика Нв Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5
UA127679C2 (uk) 2017-02-27 2023-11-29 Янссен Фармацевтика Нв Спосіб ідентифікації пацієнта, що характеризується наявністю сприйнятливості до лікування недрібноклітинного раку легені інгібітором prmt5

Also Published As

Publication number Publication date
ES2891320T3 (es) 2022-01-27
UA123637C2 (uk) 2021-05-05
US10898504B2 (en) 2021-01-26
TN2018000310A1 (en) 2020-01-16
BR112018067789B1 (pt) 2023-12-12
ZA201806016B (en) 2022-04-28
JP6909799B2 (ja) 2021-07-28
US20200289539A1 (en) 2020-09-17
MA43671A (fr) 2018-11-28
EA201892031A1 (ru) 2019-02-28
JP2019507778A (ja) 2019-03-22
BR112018067789A2 (pt) 2019-04-30
PH12018501895A1 (en) 2019-05-20

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