MX2018009849A - Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades. - Google Patents

Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades.

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Publication number
MX2018009849A
MX2018009849A MX2018009849A MX2018009849A MX2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A
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MX
Mexico
Prior art keywords
fmd
insulin
diseases
type
pancreatic
Prior art date
Application number
MX2018009849A
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English (en)
Inventor
D Longo Valter
Buono Roberta
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Univ Southern California
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Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Publication of MX2018009849A publication Critical patent/MX2018009849A/es

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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pediatric Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract

Las terapias a base de célula madre pueden revertir potencialmente la disfunción de órgano y enfermedades, pero la eliminación de tejido dañado y reactivación del programa que conduce a regeneración de órgano plantea retos mayores. En ratones, una dieta imitadora del ayuno (FMD) de cuatro días induce una expresión en forma de pasos de Sox17 y Pdx-1, pareciendo a aquella observada durante el desarrollo pancreático y seguido por generación impulsada por Ngn3 de células ß productoras de insulina. Los ciclos de FMD restauran secreción de insulina y homeostasis de glucosa tanto en modelos de ratón con diabetes tipo 1 como diabetes tipo 2. En islotes pancreáticos de diabetes tipo 1 humano, las condiciones de ayuno reducen actividad de PKA y mTOR e inducen expresión de Sox2 y Ngn3 y producción de insulina. Se revierten los efectos de la FMD por tratamiento de IGF-1 y recapitulados por inhibición de PKA y mTOR. Estos resultados indican que una FMD promueve la reprogramación de células pancreáticas para restaurar la generación de insulina en islotes de pacientes T1D y revertir ambos fenotipos T1D y T2D en modelos de ratón.
MX2018009849A 2016-02-15 2017-02-15 Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades. MX2018009849A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662295422P 2016-02-15 2016-02-15
PCT/US2017/017982 WO2017142952A1 (en) 2016-02-15 2017-02-15 Drug combinations and methods to stimulate embryonic-like regeneration to treat diabetes and other diseases

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MX2018009849A true MX2018009849A (es) 2018-11-09

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Country Link
US (1) US10660932B2 (es)
EP (1) EP3416500B1 (es)
JP (1) JP2019505592A (es)
KR (1) KR20180120153A (es)
CN (1) CN108882741A (es)
AU (1) AU2017219732B2 (es)
BR (1) BR112018016494A2 (es)
CA (1) CA3010627A1 (es)
ES (1) ES2970314T3 (es)
MX (1) MX2018009849A (es)
RU (1) RU2018131403A (es)
WO (1) WO2017142952A1 (es)
ZA (1) ZA201806113B (es)

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WO2021150715A1 (en) * 2020-01-21 2021-07-29 University Of Southern California Ketogenic fasting-mimicking diet to improve kidney function
TW202236983A (zh) * 2020-12-03 2022-10-01 南加州州立大學 提升骨骼肌再生及強度的模擬禁食生酮飲食(fmd)
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JP6727130B2 (ja) 2014-04-02 2020-07-22 ユニヴァーシティ オブ サザン カリフォルニアＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｓｏｕｔｈｅｒｎ Ｃａｌｉｆｏｒｎｉａ 自己免疫および多発性硬化症の処置
CA2982875C (en) 2015-04-16 2021-10-19 University Of Southern California Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone
HK1253090A1 (zh) 2015-05-06 2019-06-06 南加利福尼亚大学 治疗高血压和脂质紊乱的禁食模仿和加强膳食
JP7728747B2 (ja) * 2019-08-23 2025-08-25 サナ バイオテクノロジー，インコーポレイテッド Ｃｄ２４発現細胞およびそれらの用途

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