MX2018009849A - Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades. - Google Patents

Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades.

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Publication number
MX2018009849A
MX2018009849A MX2018009849A MX2018009849A MX2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A MX 2018009849 A MX2018009849 A MX 2018009849A
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MX
Mexico
Prior art keywords
fmd
insulin
diseases
type
pancreatic
Prior art date
Application number
MX2018009849A
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English (en)
Inventor
D Longo Valter
Buono Roberta
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Univ Southern California
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Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Publication of MX2018009849A publication Critical patent/MX2018009849A/es

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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract

Las terapias a base de célula madre pueden revertir potencialmente la disfunción de órgano y enfermedades, pero la eliminación de tejido dañado y reactivación del programa que conduce a regeneración de órgano plantea retos mayores. En ratones, una dieta imitadora del ayuno (FMD) de cuatro días induce una expresión en forma de pasos de Sox17 y Pdx-1, pareciendo a aquella observada durante el desarrollo pancreático y seguido por generación impulsada por Ngn3 de células ß productoras de insulina. Los ciclos de FMD restauran secreción de insulina y homeostasis de glucosa tanto en modelos de ratón con diabetes tipo 1 como diabetes tipo 2. En islotes pancreáticos de diabetes tipo 1 humano, las condiciones de ayuno reducen actividad de PKA y mTOR e inducen expresión de Sox2 y Ngn3 y producción de insulina. Se revierten los efectos de la FMD por tratamiento de IGF-1 y recapitulados por inhibición de PKA y mTOR. Estos resultados indican que una FMD promueve la reprogramación de células pancreáticas para restaurar la generación de insulina en islotes de pacientes T1D y revertir ambos fenotipos T1D y T2D en modelos de ratón.
MX2018009849A 2016-02-15 2017-02-15 Combinaciones de farmacos y metodos para estimular regeneracion de tipo embrionaria para tratar diabetes y otras enfermedades. MX2018009849A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662295422P 2016-02-15 2016-02-15
PCT/US2017/017982 WO2017142952A1 (en) 2016-02-15 2017-02-15 Drug combinations and methods to stimulate embryonic-like regeneration to treat diabetes and other diseases

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MX2018009849A true MX2018009849A (es) 2018-11-09

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US (1) US10660932B2 (es)
EP (1) EP3416500B1 (es)
JP (1) JP2019505592A (es)
KR (1) KR20180120153A (es)
CN (1) CN108882741A (es)
AU (1) AU2017219732B2 (es)
BR (1) BR112018016494A2 (es)
CA (1) CA3010627A1 (es)
ES (1) ES2970314T3 (es)
MX (1) MX2018009849A (es)
RU (1) RU2018131403A (es)
WO (1) WO2017142952A1 (es)
ZA (1) ZA201806113B (es)

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RU2749436C2 (ru) 2016-05-11 2021-06-10 Юниверсити Оф Саутерн Калифорния Диета, имитирующая голодание (FMD), в качестве иммунорегуляторного лечения желудочно-кишечных аутоиммунных/воспалительных заболеваний
US11284640B2 (en) 2017-02-14 2022-03-29 University Of Southern California Fasting mimicking diet
KR20200125966A (ko) * 2018-03-15 2020-11-05 유니버시티 오브 써던 캘리포니아 염증 및 ibd 병리의 역전을 촉진하는, 물만 섭취하는 금식이 아닌 금식 모방 식이요법 (fmd)
US20230048130A1 (en) * 2020-01-21 2023-02-16 University Of Southern California Ketogenic fasting-mimicking diet to improve kidney function
TW202236983A (zh) * 2020-12-03 2022-10-01 南加州州立大學 提升骨骼肌再生及強度的模擬禁食生酮飲食(fmd)

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US10660932B2 (en) 2020-05-26
RU2018131403A (ru) 2020-03-17
WO2017142952A1 (en) 2017-08-24
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CA3010627A1 (en) 2017-08-24
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