MX2018007725A - Celula de lavadura. - Google Patents

Celula de lavadura.

Info

Publication number
MX2018007725A
MX2018007725A MX2018007725A MX2018007725A MX2018007725A MX 2018007725 A MX2018007725 A MX 2018007725A MX 2018007725 A MX2018007725 A MX 2018007725A MX 2018007725 A MX2018007725 A MX 2018007725A MX 2018007725 A MX2018007725 A MX 2018007725A
Authority
MX
Mexico
Prior art keywords
yeast cell
promoter
orthologous
methylotrophic yeast
derepression
Prior art date
Application number
MX2018007725A
Other languages
English (en)
Inventor
VOGL Thomas
Glieder Anton
Original Assignee
Bisy E U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bisy E U filed Critical Bisy E U
Publication of MX2018007725A publication Critical patent/MX2018007725A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a una célula de levadura del género Komagataella que comprende un promotor ortólogo de una célula de levadura metilotrófica o una variante de la misma, inducible por desrepresión, en donde el promotor ortólogo es un promotor ortólogo de la formiato-deshidrogenasa (FMD) de una célula de levadura metilotrófica.
MX2018007725A 2015-12-22 2016-12-22 Celula de lavadura. MX2018007725A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15202233.1A EP3184642B1 (de) 2015-12-22 2015-12-22 Hefezelle
PCT/EP2016/082398 WO2017109082A1 (en) 2015-12-22 2016-12-22 Yeast cell

Publications (1)

Publication Number Publication Date
MX2018007725A true MX2018007725A (es) 2018-11-09

Family

ID=55068836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007725A MX2018007725A (es) 2015-12-22 2016-12-22 Celula de lavadura.

Country Status (13)

Country Link
US (1) US11891418B2 (es)
EP (2) EP3184642B1 (es)
JP (1) JP6910358B2 (es)
KR (1) KR20180088733A (es)
CN (1) CN108603213B (es)
AU (1) AU2016378641B2 (es)
CA (1) CA3009272A1 (es)
DK (2) DK3184642T3 (es)
ES (1) ES2740449T3 (es)
MX (1) MX2018007725A (es)
SG (1) SG11201805191SA (es)
UA (1) UA126112C2 (es)
WO (1) WO2017109082A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220282227A1 (en) 2019-07-05 2022-09-08 Bisy Gmbh Recombinant heme thiolate oxygenases
CN114375304A (zh) 2019-07-11 2022-04-19 克莱拉食品公司 蛋白质组合物及其食用品
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
EP3922726A1 (en) 2020-06-10 2021-12-15 Erber Aktiengesellschaft Truncated promoter for recombinant gene expression
CN117203323A (zh) 2020-12-29 2023-12-08 比西有限公司 新型酵母菌株
US11993792B2 (en) 2021-05-27 2024-05-28 New England Biolabs, Inc. DNase I variants, compositions, methods, and kits
EP4116408B1 (en) * 2021-06-24 2024-10-23 BioBoost Synbio Consulting Inc. Method for methanol free culturing of methylotrophic yeast for the biosynthesis of added value products

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE58169T1 (de) * 1986-11-24 1990-11-15 Unilever Nv Verfahren zur herstellung einer catalasefreien, oxidase enthaltenden hefe und deren verwendung.
JP3794748B2 (ja) * 1996-03-04 2006-07-12 第一アスビオファーマ株式会社 メタノール代謝系を有する微生物の培養法
AU3910000A (en) * 1999-03-22 2000-10-09 Zymogenetics Inc. Improved methods for producing proteins in transformed (pichia)
WO2002085932A2 (en) * 2001-04-24 2002-10-31 Innogenetics N.V. Constructs and methods for expression of recombinant hcv envelope proteins
DE10220894A1 (de) * 2002-05-10 2003-11-27 Rhein Biotech Proz & Prod Gmbh Promotoren mit veränderter Transkriptionseffizienz
JP5290997B2 (ja) * 2007-01-26 2013-09-18 ノボザイムス アクティーゼルスカブ ピキアにおけるメタノール誘導性プロモーターからのメタノール非依存的誘導の方法
WO2010004042A2 (en) * 2008-07-11 2010-01-14 Novozymes A/S Pichia pastoris das promoter variants
US9822357B2 (en) 2013-07-05 2017-11-21 Technische Universitat Graz Bidirectional promoter

Also Published As

Publication number Publication date
CN108603213A (zh) 2018-09-28
US20210355173A1 (en) 2021-11-18
EP3184642A1 (de) 2017-06-28
WO2017109082A1 (en) 2017-06-29
CN108603213B (zh) 2022-05-03
AU2016378641A1 (en) 2018-07-05
US11891418B2 (en) 2024-02-06
EP3394281B1 (en) 2020-08-19
EP3394281A1 (en) 2018-10-31
KR20180088733A (ko) 2018-08-06
DK3184642T3 (da) 2019-08-12
EP3184642B1 (de) 2019-05-08
DK3394281T3 (da) 2020-11-09
JP2019505194A (ja) 2019-02-28
SG11201805191SA (en) 2018-07-30
ES2740449T3 (es) 2020-02-05
AU2016378641B2 (en) 2021-04-08
UA126112C2 (uk) 2022-08-17
JP6910358B2 (ja) 2021-07-28
CA3009272A1 (en) 2017-06-29

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