MX2018007680A - Acidos nucleicos que codifican secuencias repetitivas de aminoacidos ricas en residuos de prolina y alanina que tienen secuencias nucleotidicas con baja repetitividad. - Google Patents

Acidos nucleicos que codifican secuencias repetitivas de aminoacidos ricas en residuos de prolina y alanina que tienen secuencias nucleotidicas con baja repetitividad.

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Publication number
MX2018007680A
MX2018007680A MX2018007680A MX2018007680A MX2018007680A MX 2018007680 A MX2018007680 A MX 2018007680A MX 2018007680 A MX2018007680 A MX 2018007680A MX 2018007680 A MX2018007680 A MX 2018007680A MX 2018007680 A MX2018007680 A MX 2018007680A
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Mexico
Prior art keywords
nucleic acid
amino acid
repetitive
proline
low
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MX2018007680A
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English (en)
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Binder Uli
Achatz Stefan
Skerra Arne
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Xl Protein Gmbh
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Publication of MX2018007680A publication Critical patent/MX2018007680A/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract

La presente invención se relaciona con una molécula de ácidos nucleicos que comprende una secuencia nucleotídica con baja repetitividad que codifica una secuencia repetitiva de aminoácidos rica en prolina/alanina. El polipéptido codificado comprende una secuencia repetitiva de aminoácidos que forma una espira aleatoria. La molécula de ácidos nucleicos que comprende las secuencias nucleotídicas con baja repetitividad puede comprender además, una secuencia nucleotídica que codifica una proteína biológica o farmacológicamente activa. Además, la presente invención proporciona medios y métodos de selección para identificar la molécula de ácidos nucleicos que comprende la secuencia nucleotídica con baja repetitividad. La presente invención también se relaciona con un método para preparar las moléculas de ácidos nucleicos. También se proporcionan en el presente documento métodos para preparar el polipéptido codificado o conjugados del fármaco con el polipéptido codificado utilizando las moléculas de ácidos nucleicos proporcionadas en el presente documento. El conjugado del fármaco puede comprender una proteína biológica o farmacológicamente activa o un fármaco de molécula pequeña. También se proporcionan en el presente documento vectores y hospederos que comprenden tales moléculas de ácidos nucleicos.
MX2018007680A 2015-12-22 2016-12-22 Acidos nucleicos que codifican secuencias repetitivas de aminoacidos ricas en residuos de prolina y alanina que tienen secuencias nucleotidicas con baja repetitividad. MX2018007680A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15202093 2015-12-22
PCT/EP2016/082407 WO2017109087A1 (en) 2015-12-22 2016-12-22 Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences

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MX2018007680A true MX2018007680A (es) 2018-11-14

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EP (2) EP3919623A1 (es)
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KR (1) KR102654180B1 (es)
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AU (1) AU2016378646B2 (es)
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KR102654180B1 (ko) 2024-04-04
LT3394266T (lt) 2021-08-25
HUE055267T2 (hu) 2021-11-29
JP2019508020A (ja) 2019-03-28
EA201891127A1 (ru) 2019-01-31
US20190010192A1 (en) 2019-01-10
BR112018012784A2 (pt) 2019-02-05
ES2877539T3 (es) 2021-11-17
CN109153996A (zh) 2019-01-04
IL259352A (en) 2018-07-31
AU2016378646A1 (en) 2018-06-14
JP7065772B2 (ja) 2022-05-12
KR20180088484A (ko) 2018-08-03
IL259352B (en) 2022-02-01
EP3394266A1 (en) 2018-10-31
WO2017109087A1 (en) 2017-06-29
EP3919623A1 (en) 2021-12-08
US11401305B2 (en) 2022-08-02
PL3394266T3 (pl) 2021-12-13
EP3394266B1 (en) 2021-04-14
SG11201803958WA (en) 2018-07-30
SI3394266T1 (sl) 2021-08-31
NZ742902A (en) 2023-12-22
DK3394266T3 (da) 2021-06-07
CA3005115A1 (en) 2017-06-29
AU2016378646B2 (en) 2023-03-09
CN109153996B (zh) 2022-03-25

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