MX2018007298A - Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa. - Google Patents

Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.

Info

Publication number
MX2018007298A
MX2018007298A MX2018007298A MX2018007298A MX2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A MX 2018007298 A MX2018007298 A MX 2018007298A
Authority
MX
Mexico
Prior art keywords
omega
hydroxylase
variants
fusion polypeptide
properties related
Prior art date
Application number
MX2018007298A
Other languages
English (en)
Spanish (es)
Inventor
Schirmer Andreas
Zhu Baolong
Popova Emanuela
Original Assignee
Reg Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc filed Critical Reg Life Sciences Llc
Publication of MX2018007298A publication Critical patent/MX2018007298A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01005—Lysophospholipase (3.1.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX2018007298A 2015-12-15 2016-12-13 Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa. MX2018007298A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/079832 WO2017101987A1 (en) 2015-12-15 2015-12-15 Omega-hydroxylase-related fusion polypeptide variants with improved properties
PCT/US2016/066405 WO2017106205A1 (en) 2015-12-15 2016-12-13 Omega-hydroxylase-related fusion polypeptide variants with improved properties

Publications (1)

Publication Number Publication Date
MX2018007298A true MX2018007298A (es) 2019-01-10

Family

ID=55022448

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007298A MX2018007298A (es) 2015-12-15 2016-12-13 Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.

Country Status (12)

Country Link
US (3) US10787648B2 (OSRAM)
EP (2) EP4026899A1 (OSRAM)
JP (2) JP6957469B2 (OSRAM)
KR (2) KR20250117480A (OSRAM)
CN (3) CN116334012A (OSRAM)
AU (1) AU2016370490B2 (OSRAM)
CA (1) CA3008836A1 (OSRAM)
ES (1) ES2908400T3 (OSRAM)
MX (1) MX2018007298A (OSRAM)
MY (2) MY196584A (OSRAM)
SI (1) SI3390620T1 (OSRAM)
WO (2) WO2017101987A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11441130B2 (en) 2014-06-16 2022-09-13 Genomatica, Inc. Omega-hydroxylase-related fusion polypeptides with improved properties
WO2017101987A1 (en) * 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties
EP3810778A4 (en) * 2018-05-10 2022-06-29 Genomatica, Inc. Multifunctional fatty acid derivatives and biosynthesis thereof
KR102516485B1 (ko) 2018-10-31 2023-04-03 삼성전자주식회사 폴더블 하우징을 포함하는 전자 장치

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305083C (en) 1987-02-18 1992-07-14 Yoshiharu Kimura Microorganism belonging to genus rhodococcus, and a process for producing alkene derivative and unsaturated fatty acid
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
WO2003093215A1 (en) 2002-04-29 2003-11-13 Dow Global Technologies Inc. Intergrated chemical processes for industrial utilization of seed oils
US20080220419A1 (en) 2004-11-10 2008-09-11 Marine Biotechnology Institute Co., Ltd. Method of Isolating P450 Gene
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
EP2157170B1 (en) 2006-05-19 2014-01-15 LS9, Inc. Production of fatty acids and derivatives thereof
CN106083579A (zh) 2006-10-13 2016-11-09 埃莱文斯可更新科学公司 通过烯烃复分解由内烯烃合成末端烯烃的方法
DK2121546T3 (en) 2006-10-13 2018-03-12 Elevance Renewable Sciences Process for preparing omega-dicarboxylic acid olefin derivative by metathesis
WO2008113041A2 (en) 2007-03-14 2008-09-18 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
BRPI0809345A2 (pt) 2007-03-28 2014-10-07 Ls9 Inc Células recombinantes, composições produzidas por estas, métodos para produzir derivados de ácidos graxos em uma célula recombinante, para aumentar a produção de derivados de ácidos graxos em uma célula recombinante, construto recombinante, vetores, métodos para aumentar a produção de derivados de ácidos graxos em uma célula hospedeira de produção, para produzir derivados de ácidos graxos, derivados de ácidos graxos, composições de biocombustível.
US20080293060A1 (en) 2007-04-23 2008-11-27 Ls9, Inc. Methods and Compositions for Identification of Hydrocarbon Response, Transport and Biosynthesis Genes
US9200299B2 (en) 2007-05-22 2015-12-01 REG Life Sciences, LLC Genetically engineered cell encoding ole amino acid motifs in a carbon source producing aliphatic ketones or olefins
JP5324129B2 (ja) 2007-05-25 2013-10-23 神戸天然物化学株式会社 Ｃｙｐ１５３による芳香族化合物の製造方法
US20100199548A1 (en) 2007-07-06 2010-08-12 Ls9, Inc. Systems and methods for the production of fatty esters
FR2921362B1 (fr) 2007-09-20 2012-09-21 Arkema France Procede de synthese d'acides gras omega-insatures
CN101802208B (zh) 2007-09-27 2016-05-18 Reg生命科学有限责任公司 通过提取式发酵减少原料中杂质的毒性作用
TWI351779B (en) 2007-12-03 2011-11-01 Advance Smart Ind Ltd Apparatus and method for correcting residual capac
WO2009085278A1 (en) 2007-12-21 2009-07-09 Ls9, Inc. Methods and compositions for producing olefins
MX350285B (es) 2008-05-16 2017-09-04 Reg Life Sciences Llc Métodos y composiciones para producir hidrocarburos.
US8232924B2 (en) 2008-05-23 2012-07-31 Alliant Techsystems Inc. Broadband patch antenna and antenna system
US8273694B2 (en) 2008-07-28 2012-09-25 Jeffrey A Brown Synthetic compositions obtained from algae
WO2010022090A1 (en) 2008-08-18 2010-02-25 Ls9, Inc. Systems and methods for the production of mixed fatty esters
KR101258347B1 (ko) 2008-08-28 2013-04-30 미쓰이 가가쿠 가부시키가이샤 올레핀의 제조 방법
ES2550467T3 (es) 2008-10-07 2015-11-10 REG Life Sciences, LLC Métodos y composiciones para producir aldehídos grasos
ES2505115T3 (es) 2008-10-28 2014-10-09 Ls9, Inc. Métodos para producir alcoholes grasos
US7989875B2 (en) 2008-11-24 2011-08-02 Nxp B.V. BiCMOS integration of multiple-times-programmable non-volatile memories
MX368526B (es) 2008-12-23 2019-10-07 Reg Life Sciences Llc Metodos y composiciones relacionados con tioesterasa enzima.
US8071799B2 (en) 2009-01-29 2011-12-06 Energy & Environmental Research Center Foundation Chain-selective synthesis of fuel components and chemical feedstocks
EP2417244A4 (en) 2009-04-10 2015-10-14 Reg Life Sciences Llc PRODUCTION OF COMMERCIAL BIODIESEL FROM GENETICALLY MODIFIED MICROORGANISMS
CN102459622B (zh) 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
BRPI1009980A2 (pt) 2009-05-01 2015-08-25 Univ California Produtos de ésteres de ácidos graxos a partir de polímeros de biomassa
BR112012006681A2 (pt) 2009-09-25 2015-09-08 Ls9 Inc método para produzir uma composição de ésteres de ácidos graxos, composição de ésteres de ácidos graxos método para produzir uma composição de ésteres graxos e composição de biocombustivel
US8809563B2 (en) 2009-11-09 2014-08-19 Exxonmobil Chemical Patents Inc. Metathesis catalyst and process for use thereof
US8237003B2 (en) 2009-11-09 2012-08-07 Exxonmobil Chemical Patents Inc. Metathesis catalyst and process for use thereof
US8361769B1 (en) * 2009-11-16 2013-01-29 U.S. Department Of Energy Regioselective alkane hydroxylation with a mutant CYP153A6 enzyme
US20110124071A1 (en) 2009-11-17 2011-05-26 LS9, Inc Methods and compositions for producing hydrocarbons
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
US20110250663A1 (en) 2010-04-08 2011-10-13 Ls9, Inc. Methods and compositions related to fatty alcohol biosynthetic enzymes
SG10201504187YA (en) 2010-05-28 2015-06-29 Solazyme Inc Tailored oils produced from recombinant heterotrophic microorganisms
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
WO2012071439A1 (en) 2010-11-22 2012-05-31 The Regents Of The University Of California Host cells and methods for producing diacid compounds
JP6071904B2 (ja) 2011-02-02 2017-02-01 テラヴィア ホールディングス， インコーポレイテッド 組み換え油産生微生物から生成される用途に応じた油
US9738913B2 (en) 2011-07-06 2017-08-22 Verdezyne, Inc. Biological methods for preparing a fatty dicarboxylic acid
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
EP2639308A1 (de) 2012-03-12 2013-09-18 Evonik Industries AG Enzymatische omega-Oxidation und -Aminierung von Fettsäuren
FR3003577B1 (fr) 2013-03-19 2016-05-06 Ferropem Inoculant a particules de surface
KR20220053681A (ko) * 2013-06-14 2022-04-29 게노마티카 인코포레이티드 오메가-수산화 지방산 유도체를 생성하는 방법들
US11441130B2 (en) * 2014-06-16 2022-09-13 Genomatica, Inc. Omega-hydroxylase-related fusion polypeptides with improved properties
WO2017101987A1 (en) * 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties

Also Published As

Publication number Publication date
CN108699536A (zh) 2018-10-23
CA3008836A1 (en) 2017-06-22
AU2016370490B2 (en) 2023-01-05
EP3390620B1 (en) 2022-01-05
US20230159901A1 (en) 2023-05-25
WO2017101987A1 (en) 2017-06-22
AU2016370490A1 (en) 2018-06-21
WO2017106205A1 (en) 2017-06-22
JP7458358B2 (ja) 2024-03-29
KR20180132604A (ko) 2018-12-12
CN108699536B (zh) 2022-08-02
US20190002845A1 (en) 2019-01-03
EP4026899A1 (en) 2022-07-13
US10787648B2 (en) 2020-09-29
KR20250117480A (ko) 2025-08-04
JP2018537111A (ja) 2018-12-20
EP3390620A1 (en) 2018-10-24
JP6957469B2 (ja) 2021-11-02
CN116334013A (zh) 2023-06-27
JP2022002535A (ja) 2022-01-11
KR102840377B1 (ko) 2025-08-01
US11384341B2 (en) 2022-07-12
CN116334012A (zh) 2023-06-27
SI3390620T1 (sl) 2022-05-31
BR112018012193A2 (pt) 2018-12-04
MY194277A (en) 2022-11-25
US20210230562A1 (en) 2021-07-29
ES2908400T3 (es) 2022-04-29
MY196584A (en) 2023-04-19
US12180515B2 (en) 2024-12-31

Similar Documents

Publication Publication Date Title
CO2017005639A2 (es) Anticuerpos anti-miostatina, polipéptidos que contienen regiones fc variantes
MX392571B (es) Procesos para producir productos de fermentación.
CR20150658A (es) Montajes de mezcla que incluyen impulsores magnéticos
BR112017016301A2 (pt) novo promotor e usos do mesmo
CL2017000752A1 (es) Procedimiento para producir biomasa que tiene un alto contenido de exopolisacáridos
MX2017008817A (es) Composiciones y metodos para la glicosilacion de proteinas.
EP3221446C0 (en) IN VITRO PRODUCTION OF EXPANDED POTENTIAL STEM CELLS
BR112017017886A2 (pt) gerando populações de células endoteliais arteriais
AU366791S (en) Led reflector array
MX2015012875A (es) Composiciones de cultivo celular con antioxidantes y metodos para la produccion de polipeptidos.
BR112017013394A2 (pt) fabricação de proteína
MX2016013631A (es) Celulas huespedes modificadas y usos de las mismas.
CL2016001900A1 (es) Sobreexpresión de los reguladores de caminos de n-glicosilación para regular la glicosilación de proteinas recombinante
AU366790S (en) Led reflector array
MX2016008258A (es) Celulas eucariotas novedosas y metodos para la expresion recombinante de un producto de interes.
DOP2016000220A (es) PROTEÍNAS DE FUSIÓN TATk-CDKL5, COMPOSICIONES, FORMULACIONES Y USO DE ESTAS.
MX2018007298A (es) Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.
UY36617A (es) Proteínas de fusión inmunogénicas para el tratamiento del cáncer
MX372803B (es) Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas.
BR112018008045A2 (pt) micro-organismo recombinante que produz l-treonina e um método para produzir l-treonina com o uso do mesmo
MX2017007103A (es) Variantes de lipasa y polinucleotidos que las codifican.
CL2017002661A1 (es) Método de producción de gonadotrofina
BR112016027341A2 (pt) micro-organismo do gênero escherichia que tem um nível de atp intracelular aumentado e método para produzir l-aminoácidos
CL2017001383A1 (es) Proceso para la fabricación de anhídrido carboxílico
BR112018009245A2 (pt) drimenol sintases iii