MX2018006030A - Inmunoensayo para la determinacion de anticuerpos modificados en la region de fragmento cristalizable (fc). - Google Patents
Inmunoensayo para la determinacion de anticuerpos modificados en la region de fragmento cristalizable (fc).Info
- Publication number
- MX2018006030A MX2018006030A MX2018006030A MX2018006030A MX2018006030A MX 2018006030 A MX2018006030 A MX 2018006030A MX 2018006030 A MX2018006030 A MX 2018006030A MX 2018006030 A MX2018006030 A MX 2018006030A MX 2018006030 A MX2018006030 A MX 2018006030A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- antigen
- immobilized
- determination
- amount
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se relaciona con un método para la determinación de la cantidad de un anticuerpo bivalente en una muestra de suero o plasma obtenida de un animal de experimentación no humano, en donde el anticuerpo comprende una o más mutaciones en la región Fc en comparación con la región Fc de tipo salvaje correspondiente que tiene una secuencia de SEC ID NO: 01, 02 ? 03, en donde el método comprende las siguientes etapas: a) inmovilizar un polipéptido no anticuerpo al que se conjuga covalentemente más de una copia del antígeno del anticuerpo en una superficie sólida, b) incubar el antígeno inmovilizado con la muestra para formar un complejo antígeno-anticuerpo inmovilizado, c) incubar el complejo antígeno-anticuerpo inmovilizado con el antígeno conjugado con una etiqueta detectable para formar un complejo ternario inmovilizado, y d) determinar la cantidad de anticuerpo determinando la cantidad de la etiqueta detectable en el complejo ternario inmovilizado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15197058 | 2015-11-30 | ||
PCT/EP2016/079086 WO2017093226A1 (en) | 2015-11-30 | 2016-11-29 | Immunoassay for the determination of fc-region modified antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018006030A true MX2018006030A (es) | 2018-08-01 |
Family
ID=54770889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018006030A MX2018006030A (es) | 2015-11-30 | 2016-11-29 | Inmunoensayo para la determinacion de anticuerpos modificados en la region de fragmento cristalizable (fc). |
Country Status (12)
Country | Link |
---|---|
US (1) | US11561229B2 (es) |
EP (1) | EP3384293B1 (es) |
JP (1) | JP6807944B2 (es) |
KR (1) | KR102628570B1 (es) |
CN (2) | CN108351361A (es) |
AU (1) | AU2016363638B2 (es) |
BR (1) | BR112018008789A2 (es) |
CA (1) | CA3004199C (es) |
HK (1) | HK1258302A1 (es) |
IL (1) | IL259053A (es) |
MX (1) | MX2018006030A (es) |
WO (1) | WO2017093226A1 (es) |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2095818B (en) | 1981-03-27 | 1985-10-02 | Exxon Research Engineering Co | Staged adsorption/resorption heat pump |
US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
JPH01223351A (ja) * | 1988-03-03 | 1989-09-06 | Dainippon Pharmaceut Co Ltd | 抗体の定量方法および定量用試薬 |
IL92164A (en) | 1988-11-03 | 1996-01-19 | Igen Inc | Particle-based electrochemiluminescent test method |
US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Luminescence test method and device based on magnetic tiny particles, containing many magnets |
AU4698096A (en) * | 1995-01-18 | 1996-08-07 | First Medical, Inc. | Method for immobilizing haptens on a test article |
US20040242848A1 (en) * | 2003-04-21 | 2004-12-02 | Owens S. Michael | Mouse/human chimeric anti-phencyclidine antibody and uses thereof |
US7658930B2 (en) | 2005-02-02 | 2010-02-09 | Peng Cui | Kit for detecting the antibody of HCV and its preparing method |
RU2296332C1 (ru) | 2005-10-28 | 2007-03-27 | Общество с ограниченной ответственностью "ДИАМЕДИКА" | Способ ранней диагностики факта потребления наркотических веществ в отсутствие клинических признаков состояния зависимости от наркотиков |
TWI426920B (zh) * | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
CN104428006B (zh) | 2012-07-04 | 2017-09-08 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原‑抗体缀合物 |
CN104471397B (zh) * | 2012-07-13 | 2018-03-23 | 弗·哈夫曼-拉罗切有限公司 | 用于检测多特异性结合物的方法 |
RU2694981C2 (ru) * | 2014-01-03 | 2019-07-18 | Ф. Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения |
-
2016
- 2016-11-29 CA CA3004199A patent/CA3004199C/en active Active
- 2016-11-29 CN CN201680067452.9A patent/CN108351361A/zh not_active Withdrawn
- 2016-11-29 WO PCT/EP2016/079086 patent/WO2017093226A1/en active Application Filing
- 2016-11-29 EP EP16805057.3A patent/EP3384293B1/en active Active
- 2016-11-29 MX MX2018006030A patent/MX2018006030A/es unknown
- 2016-11-29 KR KR1020187018326A patent/KR102628570B1/ko active IP Right Grant
- 2016-11-29 CN CN202410287161.7A patent/CN118150838A/zh active Pending
- 2016-11-29 BR BR112018008789-0A patent/BR112018008789A2/pt unknown
- 2016-11-29 AU AU2016363638A patent/AU2016363638B2/en active Active
- 2016-11-29 JP JP2018546758A patent/JP6807944B2/ja active Active
-
2018
- 2018-04-30 IL IL259053A patent/IL259053A/en active IP Right Grant
- 2018-05-24 US US15/988,939 patent/US11561229B2/en active Active
-
2019
- 2019-01-15 HK HK19100667.1A patent/HK1258302A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
KR102628570B1 (ko) | 2024-01-23 |
WO2017093226A1 (en) | 2017-06-08 |
AU2016363638A1 (en) | 2018-05-24 |
CA3004199C (en) | 2024-05-07 |
KR20180082597A (ko) | 2018-07-18 |
BR112018008789A2 (pt) | 2018-10-30 |
JP2018536881A (ja) | 2018-12-13 |
CA3004199A1 (en) | 2017-06-08 |
AU2016363638B2 (en) | 2022-04-21 |
CN108351361A (zh) | 2018-07-31 |
JP6807944B2 (ja) | 2021-01-06 |
HK1258302A1 (zh) | 2019-11-08 |
US11561229B2 (en) | 2023-01-24 |
US20180364251A1 (en) | 2018-12-20 |
EP3384293B1 (en) | 2020-07-08 |
IL259053A (en) | 2018-07-31 |
EP3384293A1 (en) | 2018-10-10 |
CN118150838A (zh) | 2024-06-07 |
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