MX2018005313A - Vesiculas extracelulares de las celulas neurales. - Google Patents

Vesiculas extracelulares de las celulas neurales.

Info

Publication number
MX2018005313A
MX2018005313A MX2018005313A MX2018005313A MX2018005313A MX 2018005313 A MX2018005313 A MX 2018005313A MX 2018005313 A MX2018005313 A MX 2018005313A MX 2018005313 A MX2018005313 A MX 2018005313A MX 2018005313 A MX2018005313 A MX 2018005313A
Authority
MX
Mexico
Prior art keywords
vessicles
neural cell
cell extracellular
evs
extracellular
Prior art date
Application number
MX2018005313A
Other languages
English (en)
Inventor
L Stice Steven
Lynn WEBB Robin
A Stice Tracy
Original Assignee
Univ Georgia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia filed Critical Univ Georgia
Publication of MX2018005313A publication Critical patent/MX2018005313A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5063Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068Cell membranes or bacterial membranes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5176Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0622Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)

Abstract

Se describen en el presente documento vesículas extracelulares (EV) neurales y métodos para utilizar estas EV en el tratamiento de lesión de la médula espinal, accidente cerebrovascular y lesión traumática del cerebro y enfermedades neurodegenerativas.
MX2018005313A 2015-11-18 2016-11-16 Vesiculas extracelulares de las celulas neurales. MX2018005313A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562256823P 2015-11-18 2015-11-18
PCT/US2016/062245 WO2017087500A1 (en) 2015-11-18 2016-11-16 Neural cell extracellular vessicles

Publications (1)

Publication Number Publication Date
MX2018005313A true MX2018005313A (es) 2018-09-05

Family

ID=58717775

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005313A MX2018005313A (es) 2015-11-18 2016-11-16 Vesiculas extracelulares de las celulas neurales.

Country Status (15)

Country Link
US (3) US11993787B2 (es)
EP (1) EP3377078A4 (es)
JP (2) JP7075594B2 (es)
KR (1) KR20180086440A (es)
CN (1) CN108697740A (es)
AU (1) AU2016357303B2 (es)
BR (1) BR112018009891A2 (es)
CA (1) CA3004450A1 (es)
EA (1) EA201891152A1 (es)
HK (1) HK1256911A1 (es)
IL (1) IL259470B (es)
MX (1) MX2018005313A (es)
NZ (1) NZ742327A (es)
SG (1) SG11201804117XA (es)
WO (1) WO2017087500A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7075594B2 (ja) 2015-11-18 2022-05-26 ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド 神経細胞の細胞外小胞
US11073511B2 (en) * 2016-02-01 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
CN110317788A (zh) * 2019-04-26 2019-10-11 广州瑞臻再生医学科技有限公司 一种npc培养基、外泌体的制备方法和应用
CN117384828A (zh) * 2019-06-10 2024-01-12 布瑞克斯奥根株式会社 用于促进干细胞来源外泌体产生和增加干性的包含透明质酸的组合物
JP2022549328A (ja) * 2019-09-25 2022-11-24 コディアック バイオサイエンシーズ, インコーポレイテッド 細胞外小胞組成物
EP4054631A1 (en) * 2019-11-04 2022-09-14 Aruna Biomedical, Inc. Extracellular vesicles and uses thereof for antibody delivery
KR102630220B1 (ko) * 2019-11-12 2024-01-29 브렉소젠 주식회사 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 신장 질환의 예방 또는 치료용 조성물
WO2021184020A1 (en) * 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Methods of treating neuroinflammation
WO2021198954A1 (en) * 2020-03-31 2021-10-07 Universidade Do Minho Exosome-enriched extracellualr vesicles isolation, method and uses thereof
CN113577108B (zh) * 2021-08-31 2023-07-07 中国科学院苏州纳米技术与纳米仿生研究所 一种多功能胶原支架、其制备方法与应用
CN113887569B (zh) * 2021-09-09 2022-10-25 同济大学 一种基于区域尺度的事故多发区域判别方法
WO2023055222A1 (ko) * 2021-10-01 2023-04-06 주식회사 입셀 유도만능줄기세포 배양 배지 유래 성분을 포함하는 조성물 내지 이의 용도
WO2023056606A1 (en) * 2021-10-08 2023-04-13 Hangzhou Jijing Pharmaceutical Technology Limited Valproate (vpa) compounds for use in treating spinocerebellar ataxia type 1 (sca1)
JP7371975B1 (ja) 2022-09-27 2023-10-31 セルソース株式会社 細胞外小胞の製造方法及び細胞外小胞含有組成物

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4440921A (en) 1982-06-21 1984-04-03 Research Corporation Coupling of polyorganophosphazenes to carboxylic acid
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4880622A (en) 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
EP1812556A4 (en) * 2004-10-05 2011-02-02 Univ Georgia NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
WO2006087233A2 (en) * 2005-02-21 2006-08-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells
PT2419144T (pt) 2009-04-17 2019-09-16 Univ Oxford Innovation Ltd Composição para a administração de material genético
CN103210089A (zh) 2010-08-13 2013-07-17 格拉斯哥大学大学行政评议会 微泡和相关的微小rna的治疗用途
SG183579A1 (en) 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
GB201121070D0 (en) * 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
TR201802778T4 (tr) 2011-12-13 2018-03-21 Ford Henry Health System Hücre kaynaklı/vezikül bazlı mikrorna verilişi için yöntemler, sistemler ve kompozisyonlar.
US20150079046A1 (en) * 2012-04-03 2015-03-19 Reneuron Limited Stem cell microparticles
US10231997B2 (en) 2012-08-15 2019-03-19 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
US10308959B2 (en) 2013-01-18 2019-06-04 Henry Ford Health System Methods, systems, and compositions relating to MiRNA-146a
ES2662326T5 (es) 2013-04-12 2021-08-04 Evox Therapeutics Ltd Vesículas de suministro terapéutico
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
WO2015038065A1 (en) 2013-09-11 2015-03-19 Nanyang Technological University Plasma microvesicle biomarkers for ischemic stroke
US20160220613A1 (en) * 2013-09-16 2016-08-04 Agency For Science, Technology And Research Method
EP3057662A4 (en) 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antibody dependent exosome therapy
FR3014198B1 (fr) 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
CN103740645A (zh) * 2013-12-06 2014-04-23 山西医科大学 神经干细胞来源Exosomes制备及在神经系统疾病中的应用
US9919011B2 (en) 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
US10513710B2 (en) 2014-04-18 2019-12-24 University Of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
JP6716564B2 (ja) 2014-12-03 2020-07-01 カプリコール,インコーポレイテッド 安定したエクソソーム製剤の製造方法
WO2016172598A1 (en) 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
CA2997811C (en) 2015-10-01 2021-09-21 University Of Ottawa Exosome packaging of nucleic acids
JP7075594B2 (ja) 2015-11-18 2022-05-26 ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド 神経細胞の細胞外小胞
WO2017188487A1 (ko) 2016-04-29 2017-11-02 삼성전자 주식회사 줄기세포 유래의 세포외 소포체 생산 방법
MX2019005140A (es) 2016-11-02 2020-01-20 J Prockop Darwin Exosomas y usos de los mismos en enfermedades del cerebro.

Also Published As

Publication number Publication date
AU2016357303B2 (en) 2023-11-30
HK1256911A1 (zh) 2019-10-04
NZ742327A (en) 2020-01-31
WO2017087500A8 (en) 2018-05-31
US11993787B2 (en) 2024-05-28
EA201891152A1 (ru) 2018-12-28
SG11201804117XA (en) 2018-06-28
EP3377078A4 (en) 2019-09-04
EP3377078A1 (en) 2018-09-26
IL259470A (en) 2018-07-31
BR112018009891A2 (pt) 2018-12-26
US11111475B2 (en) 2021-09-07
JP7075594B2 (ja) 2022-05-26
KR20180086440A (ko) 2018-07-31
AU2016357303A1 (en) 2018-05-10
IL259470B (en) 2022-08-01
WO2017087500A1 (en) 2017-05-26
US20180327714A1 (en) 2018-11-15
US20220356444A1 (en) 2022-11-10
JP2022009194A (ja) 2022-01-14
CA3004450A1 (en) 2017-05-26
JP2018534370A (ja) 2018-11-22
US20190352603A1 (en) 2019-11-21
CN108697740A (zh) 2018-10-23

Similar Documents

Publication Publication Date Title
MX2018005313A (es) Vesiculas extracelulares de las celulas neurales.
PH12020550805A1 (en) Exosomes for immuno-oncology and anti-inflammatory therapy
ZA201802351B (en) Electrode system, device and method for the treatment of eye diseases, in particular dry eye
EP3448504A4 (en) TREATMENT OF BRAIN STIMULATION FOR DEPRESSION
EP3156081A4 (en) Cell structure for use in treatment of brain injury, method for producing same, and therapeutic agent for brain injury
PL3349844T3 (pl) Aparat do terapii stymulacji mikroprądowej oka
PH12016500840A1 (en) Methods of using interleukin-10 for treating diseases and disorders
MX2017005834A (es) Polinucleotidos aad para el tratamiento de la enfermedad de parkinson.
RS60410B1 (sr) Kompozicije za upotrebu u metodama za tretman rana, poremećaja i bolesti kože
FI3215511T3 (fi) Substituoituja pyratsolo(1,5-a)pyrimidiinejä ja niiden käyttö lääketieteellisten häiriöiden hoitamisessa
CA2900779C (en) Compositions and methods for treating neurodegenerative diseases and cardiomyopathy
MY179105A (en) Methods of treating alzheimer's disease
EP3191172A4 (en) Nerve cuff electrode for neuromodulation in large human nerve trunks
HK1218631A1 (zh) 種藥用敷料水凝膠複合織物及其製備方法和應用
EP3664789A4 (en) METHODS OF TREATMENT OF DISEASES AND NERVE INJURY
IL272081A (en) Photodynamic therapy method for skin problems
IL261224A (en) A system for non-invasive electrical brain stimulation
MX2016016407A (es) Composiciones biofotonicas termoestables y usos de las mismas.
ZA201901090B (en) Therapeutic combinations to treat red blood cell disorders
MX2017009608A (es) Compuestos anticancerigenos.
EP3708662A4 (en) METHOD OF MANUFACTURING CULTIVATED CELL AND METHOD OF MANUFACTURING THERAPEUTIC AGENT FOR SPINAL INJURY DISEASES
GB2539742B (en) Therapeutic treatment methods, and apparatus for use therein
EP3525782A4 (en) TREATMENT OF NEUROPATHIC PAIN IN INDIVIDUALS WITH A SPINAL CORD INJURY
GB201513556D0 (en) Patch for person's skin
GB201703768D0 (en) Skin treatment methods