EA201891152A1 - Экстрацеллюлярные везикулы нервных клеток - Google Patents

Экстрацеллюлярные везикулы нервных клеток

Info

Publication number
EA201891152A1
EA201891152A1 EA201891152A EA201891152A EA201891152A1 EA 201891152 A1 EA201891152 A1 EA 201891152A1 EA 201891152 A EA201891152 A EA 201891152A EA 201891152 A EA201891152 A EA 201891152A EA 201891152 A1 EA201891152 A1 EA 201891152A1
Authority
EA
Eurasian Patent Office
Prior art keywords
extracellular
vesicules
nervous cells
extracellular vesicles
nervous
Prior art date
Application number
EA201891152A
Other languages
English (en)
Inventor
Стивен Л. Стайс
Робин Линн Уэбб
Трейси А. Стайс
Original Assignee
Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк.
Аруна Биомедикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк., Аруна Биомедикал, Инк. filed Critical Юниверсити Оф Джорджия Рисерч Фаундейшн, Инк.
Publication of EA201891152A1 publication Critical patent/EA201891152A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5063Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068Cell membranes or bacterial membranes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5176Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0622Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)

Abstract

В настоящем документе раскрываются нейральные экстрацеллюлярные везикулы (ЭВ) и способы использования указанных экстрацеллюлярных везикул при лечении травм спинного мозга, нарушения мозгового кровообращения, травматического повреждения головного мозга и нейродегенеративных заболеваний.
EA201891152A 2015-11-18 2016-11-16 Экстрацеллюлярные везикулы нервных клеток EA201891152A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562256823P 2015-11-18 2015-11-18
PCT/US2016/062245 WO2017087500A1 (en) 2015-11-18 2016-11-16 Neural cell extracellular vessicles

Publications (1)

Publication Number Publication Date
EA201891152A1 true EA201891152A1 (ru) 2018-12-28

Family

ID=58717775

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891152A EA201891152A1 (ru) 2015-11-18 2016-11-16 Экстрацеллюлярные везикулы нервных клеток

Country Status (15)

Country Link
US (3) US11993787B2 (ru)
EP (1) EP3377078A4 (ru)
JP (2) JP7075594B2 (ru)
KR (1) KR20180086440A (ru)
CN (1) CN108697740A (ru)
AU (1) AU2016357303B2 (ru)
BR (1) BR112018009891A2 (ru)
CA (1) CA3004450A1 (ru)
EA (1) EA201891152A1 (ru)
HK (1) HK1256911A1 (ru)
IL (1) IL259470B (ru)
MX (1) MX2018005313A (ru)
NZ (1) NZ742327A (ru)
SG (1) SG11201804117XA (ru)
WO (1) WO2017087500A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697740A (zh) 2015-11-18 2018-10-23 佐治亚大学研究基金会 神经细胞细胞外囊泡
US11073511B2 (en) * 2016-02-01 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers
JP7437303B2 (ja) 2017-12-29 2024-02-22 アボット・ラボラトリーズ 外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法
CN110317788A (zh) * 2019-04-26 2019-10-11 广州瑞臻再生医学科技有限公司 一种npc培养基、外泌体的制备方法和应用
EP4219686A1 (en) * 2019-06-10 2023-08-02 Brexogen Inc. Composition for promoting production of stem cell-derived exosomes and increasing stemness
MX2022003570A (es) * 2019-09-25 2022-07-11 Codiak Biosciences Inc Composiciones de vesícula extracelular.
EP4054631A1 (en) * 2019-11-04 2022-09-14 Aruna Biomedical, Inc. Extracellular vesicles and uses thereof for antibody delivery
CN114728024B (zh) * 2019-11-12 2024-05-14 布瑞克斯奥根株式会社 包含源自诱导多能干细胞来源间充质干细胞的前体细胞外泌体的用于预防或治疗肾脏疾病的组合物
WO2021184020A1 (en) * 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Methods of treating neuroinflammation
WO2021198954A1 (en) * 2020-03-31 2021-10-07 Universidade Do Minho Exosome-enriched extracellualr vesicles isolation, method and uses thereof
CN113577108B (zh) * 2021-08-31 2023-07-07 中国科学院苏州纳米技术与纳米仿生研究所 一种多功能胶原支架、其制备方法与应用
CN113887569B (zh) * 2021-09-09 2022-10-25 同济大学 一种基于区域尺度的事故多发区域判别方法
KR20230047936A (ko) * 2021-10-01 2023-04-10 주식회사 입셀 유도만능줄기세포 배양 배지 유래 성분을 포함하는 조성물 내지 이의 용도
WO2023056606A1 (en) * 2021-10-08 2023-04-13 Hangzhou Jijing Pharmaceutical Technology Limited Valproate (vpa) compounds for use in treating spinocerebellar ataxia type 1 (sca1)
JP7371975B1 (ja) 2022-09-27 2023-10-31 セルソース株式会社 細胞外小胞の製造方法及び細胞外小胞含有組成物

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4440921A (en) 1982-06-21 1984-04-03 Research Corporation Coupling of polyorganophosphazenes to carboxylic acid
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4880622A (en) 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
EP1812556A4 (en) * 2004-10-05 2011-02-02 Univ Georgia NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
WO2006087233A2 (en) * 2005-02-21 2006-08-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaft e.V. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells
US20130053426A1 (en) 2009-04-17 2013-02-28 Yiqi Seow Composition For Delivery Of Genetic Material
AU2011288262A1 (en) 2010-08-13 2013-04-04 The University Court Of The University Of Glasgow Therapeutic uses of microvesicles and related microRNAs
SG183579A1 (en) 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
WO2013090523A2 (en) 2011-12-13 2013-06-20 Henry Ford Health System Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery
EP2833893B1 (en) * 2012-04-03 2018-08-29 Reneuron Limited Stem cell microparticles
CA2882248A1 (en) * 2012-08-15 2014-02-20 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
US10308959B2 (en) 2013-01-18 2019-06-04 Henry Ford Health System Methods, systems, and compositions relating to MiRNA-146a
EP3335721A1 (en) 2013-04-12 2018-06-20 Evox Therapeutics Limited Therapeutic delivery vesicles
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
WO2015038065A1 (en) 2013-09-11 2015-03-19 Nanyang Technological University Plasma microvesicle biomarkers for ischemic stroke
US20160220613A1 (en) * 2013-09-16 2016-08-04 Agency For Science, Technology And Research Method
EP3057662A4 (en) 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antibody dependent exosome therapy
FR3014198B1 (fr) 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
CN103740645A (zh) * 2013-12-06 2014-04-23 山西医科大学 神经干细胞来源Exosomes制备及在神经系统疾病中的应用
JP6295341B2 (ja) 2014-03-18 2018-03-14 サムソン ライフ パブリック ウェルフェア ファウンデーション 幹細胞由来エキソソームを有効成分として含む脳炎症性疾患の治療用組成物
US10513710B2 (en) 2014-04-18 2019-12-24 University Of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
US20160158291A1 (en) 2014-12-03 2016-06-09 Capricor, Inc. Processes for producing stable exosome formulations
WO2016172598A1 (en) 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
WO2017054085A1 (en) 2015-10-01 2017-04-06 University Of Ottawa Exosome packaging of nucleic acids
CN108697740A (zh) 2015-11-18 2018-10-23 佐治亚大学研究基金会 神经细胞细胞外囊泡
US11643638B2 (en) 2016-04-29 2023-05-09 Samsung Electronics Co., Ltd. Method for producing stem cell-derived extracellular vesicle
MX2019005140A (es) 2016-11-02 2020-01-20 J Prockop Darwin Exosomas y usos de los mismos en enfermedades del cerebro.

Also Published As

Publication number Publication date
EP3377078A4 (en) 2019-09-04
US20220356444A1 (en) 2022-11-10
MX2018005313A (es) 2018-09-05
US20190352603A1 (en) 2019-11-21
AU2016357303B2 (en) 2023-11-30
JP2022009194A (ja) 2022-01-14
US11993787B2 (en) 2024-05-28
WO2017087500A8 (en) 2018-05-31
CA3004450A1 (en) 2017-05-26
CN108697740A (zh) 2018-10-23
AU2016357303A1 (en) 2018-05-10
NZ742327A (en) 2020-01-31
EP3377078A1 (en) 2018-09-26
US20180327714A1 (en) 2018-11-15
HK1256911A1 (zh) 2019-10-04
JP7075594B2 (ja) 2022-05-26
KR20180086440A (ko) 2018-07-31
WO2017087500A1 (en) 2017-05-26
US11111475B2 (en) 2021-09-07
IL259470B (en) 2022-08-01
IL259470A (en) 2018-07-31
SG11201804117XA (en) 2018-06-28
BR112018009891A2 (pt) 2018-12-26
JP2018534370A (ja) 2018-11-22

Similar Documents

Publication Publication Date Title
EA201891152A1 (ru) Экстрацеллюлярные везикулы нервных клеток
HK1246712A1 (zh) 神經刺激治療疾病及病症
PT3377637T (pt) Composições para uso em métodos para o tratamento de ferimentos, transtornos e doenças da pele
EA201691872A1 (ru) Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
CL2017002242A1 (es) Método para tratar un tumor cerebral
EP3429605A4 (en) THERAPEUTIC AGENT FOR THE TREATMENT OF DISEASES, IN PARTICULAR DISEASES AFFECTING THE CENTRAL NERVOUS SYSTEM
EP3156081A4 (en) Cell structure for use in treatment of brain injury, method for producing same, and therapeutic agent for brain injury
TW201613636A (en) Methods of treating Alzheimer's Disease
EP3377118A4 (en) METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER AND RELATED DISEASES
EA201691567A1 (ru) Способы лечения легких травм головного мозга
WO2016097315A3 (en) Blood brain barrier transport molecules and uses thereof
EA201492102A1 (ru) Антагонисты lingo-2 для лечения заболеваний, в которых участвуют двигательные нейроны
EP3664789A4 (en) METHODS OF TREATMENT OF DISEASES AND NERVE INJURY
IL272081A (en) Photodynamic therapy method for skin problems
MX2021006439A (es) Reguladores del cftr y metodos para su uso.
ZA202002075B (en) Compounds, compositions and methods for treatment of eye disorders and skin diseases
EA201790893A1 (ru) Способы лечения офтальмологических расстройств
ZA201901090B (en) Therapeutic combinations to treat red blood cell disorders
IL263494B1 (en) Use of lithium benzoate to treat disorders of the central nervous system
PH12017500998A1 (en) Treatment of ocular conditions using progenitor cells
WO2016182812A8 (en) Activation of neuronal store-operated calcium entry pathway for the treatment of alzheimer's disease
ZA201806894B (en) (+)-azasetron for use in the treatment of ear disorders
TH1601002196A (th) การใช้โมเลกุลที่ยึดจับเซมาโฟริน-4D สำหรับการบำบัดความผิดปกติของโรคที่มี การทำลายเซลล์ประสาทในสมอง (neurodegenerative disorder)
MA39718A (fr) Compositions et méthodes d'utilisation de celles-ci
PT3442537T (pt) (+)-azasetrom para utilização no tratamento de doenças do ouvido