MX2018001803A - Metodo para disgnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina. - Google Patents

Metodo para disgnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina.

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Publication number
MX2018001803A
MX2018001803A MX2018001803A MX2018001803A MX2018001803A MX 2018001803 A MX2018001803 A MX 2018001803A MX 2018001803 A MX2018001803 A MX 2018001803A MX 2018001803 A MX2018001803 A MX 2018001803A MX 2018001803 A MX2018001803 A MX 2018001803A
Authority
MX
Mexico
Prior art keywords
acth
syndrome
cushing
differentially diagnosing
administration
Prior art date
Application number
MX2018001803A
Other languages
English (en)
Inventor
G Moraitis Andreas
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57983847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2018001803(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of MX2018001803A publication Critical patent/MX2018001803A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/665—Assays involving proteins derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • G01N2333/695—Corticotropin [ACTH]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/048—Pituitary or hypothalamic - pituitary relationships, e.g. vasopressin or ADH related

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Esta invención proporciona un método mejorado para diagnosticar de manera diferencial el síndrome de Cushing dependiente de la ACTH. La práctica actual para diagnosticar de manera diferencial el síndrome de secreción ectópica de ACTH y la enfermedad de Cushing mide las concentraciones de ACTH relativas del seno venoso petroso inferior en comparación con el fluido obtenido de una muestra venosa periférica. Esto se realiza antes y después de la administración del factor de liberación de corticotropina exógena, o después de la administración de metirapona. Esta invención utiliza los antagonistas del receptor de glucocorticoides para inducir la liberación de la CRH endógena que estimula la ACTH para que aumente en pacientes que padecen el síndrome de secreción ectópica de ACTH, pero no en aquellos que padecen la enfermedad de Cushing.
MX2018001803A 2015-08-13 2016-08-12 Metodo para disgnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina. MX2018001803A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562204723P 2015-08-13 2015-08-13
PCT/US2016/046904 WO2017027851A1 (en) 2015-08-13 2016-08-12 Method for differentially diagnosing acth-dependent cushing's syndrome

Publications (1)

Publication Number Publication Date
MX2018001803A true MX2018001803A (es) 2018-05-16

Family

ID=57983847

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001803A MX2018001803A (es) 2015-08-13 2016-08-12 Metodo para disgnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina.

Country Status (11)

Country Link
US (6) US9829495B2 (es)
EP (1) EP3335043B1 (es)
JP (1) JP6768789B2 (es)
KR (1) KR20180052120A (es)
AU (1) AU2016305092B2 (es)
CA (1) CA2994422A1 (es)
ES (1) ES2865334T3 (es)
HK (1) HK1255714A1 (es)
IL (1) IL257439B (es)
MX (1) MX2018001803A (es)
WO (1) WO2017027851A1 (es)

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US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
WO2017027851A1 (en) 2015-08-13 2017-02-16 Corcept Therapeutics, Inc. Method for differentially diagnosing acth-dependent cushing's syndrome
MX2019011543A (es) 2017-03-31 2019-12-16 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical.
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
BR112021010461A2 (pt) 2018-12-19 2021-08-24 Corcept Therapeutics Incorporated Formulação e dose unitária para administração oral de relacorilante
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
WO2020132469A1 (en) * 2018-12-21 2020-06-25 Corcept Therapeutics Incorporated Treatment of hypercoagulopathy in cushing's syndrome by administration of glucocorticoid receptor modulators
EP3927345A4 (en) 2019-02-22 2022-12-21 Corcept Therapeutics Incorporated THERAPEUTIC USES OF RELACORILANT, A GLUCOCORTICOID RECEPTOR MODULATOR DERIVED FROM AZADECALIN FUSED TO A HETEROARYL KETONE
AU2020408057A1 (en) 2019-12-21 2022-06-16 Corcept Therapeutics Incorporated Treatment of, and differential diagnosis between, ACTH-Dependent Cushing's syndrome and ACTH-Independent Cushing's syndrome
AT18182U1 (de) * 2020-05-04 2024-04-15 Nordic Group Bv Mifepriston in oraler Form zur Verwendung bei der Zervixreifung und Geburtseinleitung
AU2023301396A1 (en) * 2022-06-28 2024-12-12 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

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Also Published As

Publication number Publication date
HK1255714A1 (zh) 2019-08-23
IL257439A (en) 2018-04-30
IL257439B (en) 2020-08-31
US20210311079A1 (en) 2021-10-07
US20180267064A1 (en) 2018-09-20
CA2994422A1 (en) 2017-02-16
AU2016305092A1 (en) 2018-04-05
US20200088745A1 (en) 2020-03-19
ES2865334T3 (es) 2021-10-15
AU2016305092B2 (en) 2022-01-27
JP6768789B2 (ja) 2020-10-14
US20170045535A1 (en) 2017-02-16
KR20180052120A (ko) 2018-05-17
US11073523B2 (en) 2021-07-27
EP3335043B1 (en) 2021-03-31
US10495650B2 (en) 2019-12-03
US20180052178A1 (en) 2018-02-22
US20230324415A1 (en) 2023-10-12
US10006924B2 (en) 2018-06-26
US9829495B2 (en) 2017-11-28
WO2017027851A1 (en) 2017-02-16
JP2018529941A (ja) 2018-10-11
EP3335043A4 (en) 2019-01-16
EP3335043A1 (en) 2018-06-20

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