MX2017016800A - Compuesto triciclico que tiene sulfinilo o sulfonilo. - Google Patents

Compuesto triciclico que tiene sulfinilo o sulfonilo.

Info

Publication number
MX2017016800A
MX2017016800A MX2017016800A MX2017016800A MX2017016800A MX 2017016800 A MX2017016800 A MX 2017016800A MX 2017016800 A MX2017016800 A MX 2017016800A MX 2017016800 A MX2017016800 A MX 2017016800A MX 2017016800 A MX2017016800 A MX 2017016800A
Authority
MX
Mexico
Prior art keywords
hydrogen atom
independently
substituted
formula
sulfinyl
Prior art date
Application number
MX2017016800A
Other languages
English (en)
Inventor
Kusano Hiroki
Yamawaki Kenji
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2017016800A publication Critical patent/MX2017016800A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

La presente invención proporciona un compuesto que muestra un fuerte espectro antibacteriano contra diversas bacterias, incluidas bacterias gramnegativas, o una composición farmacéutica que tiene una actividad antibacteriana contra bacterias resistentes a carbapenem. Se proporciona un compuesto representado por la fórmula (I): (ver Fórmula) en donde -W- es -S (=O)- o -S(=O)2-, -T- es CR4AR4B_ o - CR5AR5B-CR6AR6B-, R4A, R4B, R5A, R5B, R6A y R6B son cada uno independientemente un átomo de hidrógeno, etc., R1 es heterociclilo sustituido o no sustituido, etc., R2A y R2B son cada uno independientemente un átomo de hidrógeno, etc., o R2A y R2B se toman juntos para formar metilideno sustituido o no sustituido, etc., y R3 es un átomo de hidrógeno, etc., R11 es carboxi, etc., R7A y R7b son cada uno independientemente un átomo de hidrógeno, etc., su forma éster o una sal farmacéuticamente aceptable del mismo, o un hidrato del mismo.
MX2017016800A 2015-06-30 2016-06-30 Compuesto triciclico que tiene sulfinilo o sulfonilo. MX2017016800A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015130623 2015-06-30
PCT/JP2016/069404 WO2017002903A1 (ja) 2015-06-30 2016-06-30 スルフィニルまたはスルホニルを有する三環性化合物

Publications (1)

Publication Number Publication Date
MX2017016800A true MX2017016800A (es) 2018-04-10

Family

ID=57608195

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016800A MX2017016800A (es) 2015-06-30 2016-06-30 Compuesto triciclico que tiene sulfinilo o sulfonilo.

Country Status (15)

Country Link
US (1) US20180186814A1 (es)
EP (1) EP3318567A4 (es)
JP (1) JPWO2017002903A1 (es)
KR (1) KR20180022917A (es)
CN (1) CN107922436A (es)
AU (1) AU2016285062A1 (es)
BR (1) BR112017027720A2 (es)
CA (1) CA2990587A1 (es)
HK (1) HK1255144A1 (es)
IL (1) IL256301A (es)
MA (1) MA42311A (es)
MX (1) MX2017016800A (es)
RU (1) RU2018103188A (es)
SG (1) SG11201710330RA (es)
WO (1) WO2017002903A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR110451A1 (es) * 2016-12-26 2019-03-27 Shionogi & Co Compuesto tricíclico que tiene sulfinilo y composición farmacéutica que lo comprende
EP4237404A1 (en) * 2020-10-29 2023-09-06 Sitryx Therapeutics Limited Novel compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63152384A (ja) * 1986-07-15 1988-06-24 Takeda Chem Ind Ltd ３環性セファムまたはイソセファム化合物，その製造法および用途
JPH01226887A (ja) * 1988-03-07 1989-09-11 Takeda Chem Ind Ltd ３環性セファムまたはイソセファム化合物，その製造法およびエラスターゼ阻害剤
JPH02289584A (ja) * 1989-02-17 1990-11-29 Takeda Chem Ind Ltd セファロスポリンγ―ラクトン化合物
EP2135871A1 (en) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. New trinem antibiotics and inhibitors of beta-lactamases
US9242999B2 (en) * 2011-06-27 2016-01-26 Shionogi & Co., Ltd. Cephem compound having pyridinium group
WO2016175223A1 (ja) * 2015-04-28 2016-11-03 塩野義製薬株式会社 三環性化合物、およびそれらの使用

Also Published As

Publication number Publication date
KR20180022917A (ko) 2018-03-06
IL256301A (en) 2018-02-28
CN107922436A (zh) 2018-04-17
MA42311A (fr) 2018-05-09
JPWO2017002903A1 (ja) 2018-04-19
SG11201710330RA (en) 2018-01-30
EP3318567A1 (en) 2018-05-09
RU2018103188A3 (es) 2019-12-31
HK1255144A1 (zh) 2019-08-09
WO2017002903A1 (ja) 2017-01-05
RU2018103188A (ru) 2019-08-02
EP3318567A4 (en) 2019-01-09
US20180186814A1 (en) 2018-07-05
BR112017027720A2 (pt) 2018-11-06
AU2016285062A1 (en) 2018-01-18
CA2990587A1 (en) 2017-01-05

Similar Documents

Publication Publication Date Title
GEP20186838B (en) 5-phenoxy-3h-pyrimidin-4-one derivatives and their usage as hiv reverse transcriptase inhibitors
MX2019010446A (es) Compuestos de anillos fusionados biciclicos derivados de piridilo como inhibidores de fgfr4.
UA115320C2 (uk) Інгібітори кінази
MX2011011136A (es) Eteres diarilicos.
CA2983481A1 (en) Janus kinase inhibitor
MX2014012454A (es) Derivados de imidazotiadiazol como inhibidores del receptor 4 activado de proteasa (par4) para el tratamiento de agregacion plaquetaria.
NZ703714A (en) 2-aminopyrazine derivatives as csf-1 r kinase inhibitors
GEP20207169B (en) 3-tetrazolyl-benzene-1,2-disulfonamide derivatives as metallo-beta-lactamase inhibitors
MX2013005445A (es) Pirazolopiridinas y el uso de pirazolopiridinas como inhibidores de tirosina cinasa 2 (tyk2).
TN2018000087A1 (en) New pyrrolo[2,3-d]pyrimidine derivatives as dual dyrk1/clk1 inhibitors
GEP20197043B (en) 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis
MY194116A (en) Pharmaceutical compounds
PH12014501278A1 (en) Kinase inhibitors
UA108711C2 (uk) Сполуки триазолопіридину як інгібітори фосфодіестерази pde10a
GEP201706656B (en) 2-thiopyrimidinones
PH12019500394A1 (en) Bicyclic nitrogenated heterocyclic compound
GEP20186876B (en) Heterobicycloaryl rorc2 inhibitors and methods of use thereof
PH12018500378B1 (en) Novel annelated phenoxyacetamides
CA2904820C (en) Pyridinylpyrazoloquinoline compound
SA519410865B1 (ar) مركب حلقي شبيه بكُومارين بوصفه مثبط mek واستخدامه
ZA202200511B (en) Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of tuberculosis
MX2019011182A (es) Combinacion de derivados de isoindolinona con sgi-110.
MX2017016800A (es) Compuesto triciclico que tiene sulfinilo o sulfonilo.
MX2016006667A (es) Derivados de pirrolo-pirrolona y su uso como inhibidores.
AU2016363719A8 (en) 1,3,4-thiadiazole compounds and their use in treating cancer