MX2017004103A - Proteinas de union especificas para el receptor 1 de lipoproteinas de baja densidad oxidadas de tipo lectina (lox1) y sus usos. - Google Patents

Proteinas de union especificas para el receptor 1 de lipoproteinas de baja densidad oxidadas de tipo lectina (lox1) y sus usos.

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Publication number
MX2017004103A
MX2017004103A MX2017004103A MX2017004103A MX2017004103A MX 2017004103 A MX2017004103 A MX 2017004103A MX 2017004103 A MX2017004103 A MX 2017004103A MX 2017004103 A MX2017004103 A MX 2017004103A MX 2017004103 A MX2017004103 A MX 2017004103A
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MX
Mexico
Prior art keywords
lox1
binding proteins
disclosure provides
methods
ischemia
Prior art date
Application number
MX2017004103A
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English (en)
Inventor
Chodorge Matthieu
Buchanan Andrew
Cariuk Peter
Husmark Johanna
BALENDRAN Clare
PANDEY Deepesh
Chang Fumin
Berkowitz Daniel
ROMER Lewis
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of MX2017004103A publication Critical patent/MX2017004103A/es

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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Abstract

Esta descripción proporciona proteínas de unión a LOX1 (LOX1) tales como anticuerpos contra LOX1 y composiciones y métodos para producir estas proteínas de unión. En ciertos aspectos, las proteínas de unión a LOX1 proporcionadas en la presente inhiben la actividad de LOX1 o son antagonistas respecto a ella. Además, la descripción proporciona composiciones y métodos para diagnosticar y tratar afecciones asociadas con la aterosclerosis, trombosis, arteriopatía coronaria (CAD), isquemia (por ejemplo, isquemia de miocardio), infarto (por ejemplo, infarto de miocardio), síndrome coronario agudo (ACS), accidente cerebrovascular, lesión por reperfusión, reestenosis, enfermedad vascular periférica, hipertensión, insuficiencia cardiaca, inflamación (por ejemplo, inflamación crónica), angiogénesis, preeclampsia, cáncer y otras enfermedades y afecciones mediadas por LOX1.
MX2017004103A 2014-10-01 2015-09-30 Proteinas de union especificas para el receptor 1 de lipoproteinas de baja densidad oxidadas de tipo lectina (lox1) y sus usos. MX2017004103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462058254P 2014-10-01 2014-10-01
PCT/EP2015/072644 WO2016050889A1 (en) 2014-10-01 2015-09-30 Binding proteins specific for lox1 and uses thereof

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MX2017004103A true MX2017004103A (es) 2017-07-07

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US (3) US10117889B2 (es)
EP (1) EP3201233A1 (es)
JP (2) JP6709212B2 (es)
KR (1) KR102571909B1 (es)
CN (2) CN113583130A (es)
AU (2) AU2015326891B2 (es)
CA (1) CA2962731A1 (es)
CL (1) CL2017000757A1 (es)
CO (1) CO2017003777A2 (es)
IL (1) IL250796B (es)
MX (1) MX2017004103A (es)
MY (1) MY188292A (es)
NZ (1) NZ729600A (es)
RU (1) RU2764993C2 (es)
SG (2) SG10202001114PA (es)
WO (1) WO2016050889A1 (es)

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AR096601A1 (es) 2013-06-21 2016-01-20 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
US9562101B2 (en) 2013-06-21 2017-02-07 Novartis Ag Lectin-like oxidized LDL receptor 1 antibodies and methods of use
MA43342A (fr) 2015-09-30 2018-08-08 Medimmune Ltd Compositions et procédé d'inhibition de cellules souches cancéreuses
US20230122067A1 (en) * 2020-03-26 2023-04-20 Denka Company Limited REAGENT COMPRISING ANTIBODY FROM WHICH PART OF Fc REGION IS DELETED
AU2021306709A1 (en) 2020-07-06 2023-02-09 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting SARS-CoV-2
AU2021332340A1 (en) 2020-08-26 2023-10-05 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting sars-cov-2
TW202306991A (zh) 2021-04-30 2023-02-16 英商梅迪繆思有限公司 用於治療血管炎症、動脈粥樣硬化和相關障礙之方法
CN115477704B (zh) * 2021-06-16 2024-02-23 四川大学华西医院 一种基于lox1构建的嵌合抗原受体免疫细胞制备及其应用
WO2023172699A1 (en) * 2022-03-10 2023-09-14 The Board Of Trustees Of The Leland Stanford Junior University Treatment of coronary artery disease

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JP5232818B2 (ja) * 1998-08-06 2013-07-10 達也 沢村 酸化ｌｄｌ受容体に対する抗体を含んでなる医薬組成物
US20030143226A1 (en) * 2000-03-02 2003-07-31 Yuko Kobayashi Human monoclonal antibodies against oxidized ldl receptor and medicinal use thereof
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AR096601A1 (es) 2013-06-21 2016-01-20 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
US9562101B2 (en) * 2013-06-21 2017-02-07 Novartis Ag Lectin-like oxidized LDL receptor 1 antibodies and methods of use

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JP6709212B2 (ja) 2020-06-10
US10117889B2 (en) 2018-11-06
CN108064243A (zh) 2018-05-22
US20170304343A1 (en) 2017-10-26
RU2017115071A3 (es) 2019-04-29
US20190262368A1 (en) 2019-08-29
SG11201702385TA (en) 2017-04-27
SG10202001114PA (en) 2020-03-30
AU2015326891A1 (en) 2017-03-23
BR112017006609A2 (pt) 2017-12-12
CL2017000757A1 (es) 2018-04-20
WO2016050889A1 (en) 2016-04-07
CA2962731A1 (en) 2016-04-07
CN113583130A (zh) 2021-11-02
KR20170062502A (ko) 2017-06-07
RU2017115071A (ru) 2018-11-07
JP2020188765A (ja) 2020-11-26
IL250796A0 (en) 2017-04-30
RU2764993C2 (ru) 2022-01-24
NZ729600A (en) 2023-09-29
US11078284B2 (en) 2021-08-03
IL250796B (en) 2022-04-01
MY188292A (en) 2021-11-25
CO2017003777A2 (es) 2017-07-11
JP2017531426A (ja) 2017-10-26
US20210347900A1 (en) 2021-11-11
EP3201233A1 (en) 2017-08-09
AU2015326891B2 (en) 2021-04-08
CN108064243B (zh) 2021-08-27
KR102571909B1 (ko) 2023-08-28
AU2021204798A1 (en) 2021-08-05

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