MX2016005657A - Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas. - Google Patents

Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas.

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Publication number
MX2016005657A
MX2016005657A MX2016005657A MX2016005657A MX2016005657A MX 2016005657 A MX2016005657 A MX 2016005657A MX 2016005657 A MX2016005657 A MX 2016005657A MX 2016005657 A MX2016005657 A MX 2016005657A MX 2016005657 A MX2016005657 A MX 2016005657A
Authority
MX
Mexico
Prior art keywords
cells
differentiation
clustering
suspension
pluripotent stem
Prior art date
Application number
MX2016005657A
Other languages
English (en)
Spanish (es)
Inventor
Shelley Nelson
Benjamin Fryer
Daina Laniauskas
Marcia Blackmoore
Haiyun Wang
Kostadinka Lilova
Elizabeth Rosocha
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/998,974 external-priority patent/US10377989B2/en
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2016005657A publication Critical patent/MX2016005657A/es

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    • C12N5/0676Pancreatic cells
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    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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MX2016005657A 2013-11-01 2014-05-21 Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas. MX2016005657A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361962158P 2013-11-01 2013-11-01
US13/998,974 US10377989B2 (en) 2012-12-31 2013-12-30 Methods for suspension cultures of human pluripotent stem cells
PCT/US2014/038993 WO2015065524A2 (en) 2013-11-01 2014-05-21 Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells

Publications (1)

Publication Number Publication Date
MX2016005657A true MX2016005657A (es) 2017-01-05

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Application Number Title Priority Date Filing Date
MX2016005657A MX2016005657A (es) 2013-11-01 2014-05-21 Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas.
MX2016005658A MX2016005658A (es) 2013-11-01 2014-06-17 Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas.

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MX2016005658A MX2016005658A (es) 2013-11-01 2014-06-17 Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas.

Country Status (12)

Country Link
EP (2) EP3063268A4 (ko)
JP (2) JP2016534731A (ko)
KR (4) KR20160079072A (ko)
CN (2) CN105793413A (ko)
AU (4) AU2014342995C1 (ko)
BR (1) BR112016009393A8 (ko)
CA (2) CA2928639A1 (ko)
MX (2) MX2016005657A (ko)
PH (2) PH12016500782A1 (ko)
RU (2) RU2689710C2 (ko)
SG (2) SG11201603045VA (ko)
WO (2) WO2015065524A2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160079072A (ko) * 2013-11-01 2016-07-05 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 인간 만능 줄기세포의 현탁 및 클러스터링
RU2771328C2 (ru) * 2016-06-23 2022-04-29 Титон Биотек, Инк. Клетки, экспрессирующие рецептор паратиреоидного гормона 1, и их применение
WO2018090084A1 (en) * 2016-11-16 2018-05-24 Cynata Therapeutics Limited Pluripotent stem cell assay
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CN111246864A (zh) * 2017-07-21 2020-06-05 森玛治疗公司 干细胞衍生的胰腺β细胞的重聚
JP7000896B2 (ja) * 2017-08-23 2022-01-19 王子ホールディングス株式会社 細胞シート形成部材、細胞シート形成部材の製造方法、および、細胞シートの製造方法
CA3087344A1 (en) * 2018-01-05 2019-07-11 Platelet Biogenesis, Inc. Compositions and methods for producing megakaryocytes
EP3740566A4 (en) * 2018-01-18 2021-10-27 Agency for Science, Technology and Research METHOD OF DIFFERENTIATING HUMAN PLURIPOTENT STEM CELL LINES IN A SUSPENSION CULTURE
KR102115360B1 (ko) * 2018-05-30 2020-05-26 주식회사 바이블리오테카 성체 줄기세포 배양액 및 그 제조방법
US10724052B2 (en) 2018-09-07 2020-07-28 Crispr Therapeutics Ag Universal donor cells
CN114206407A (zh) 2019-05-31 2022-03-18 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
CN114173837A (zh) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
JP7328362B2 (ja) 2019-05-31 2023-08-16 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 制御された酸素拡散距離を伴う細胞カプセル化デバイス
US11118196B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
KR20220058579A (ko) 2019-09-05 2022-05-09 크리스퍼 테라퓨틱스 아게 보편적 공여자 세포
EP4061929A1 (en) * 2019-11-22 2022-09-28 Novo Nordisk A/S Spin-aggregated neural microspheres and the application thereof
US11566230B2 (en) 2020-12-31 2023-01-31 Crispr Therapeutics Ag Universal donor cells
US20240191185A1 (en) * 2021-03-25 2024-06-13 Kaneka Corporation Method for producing pluripotent stem cell population
CN116218766A (zh) * 2023-04-21 2023-06-06 北京意胜生物科技有限公司 一种制备胰腺前体细胞的方法、培养基及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0500699A3 (en) * 2001-11-09 2010-01-28 Artecel Sciences Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof
PT2733203T (pt) * 2006-08-02 2019-01-23 Technion Res & Dev Foundation Métodos de expansão de células estminais embrionárias numa cultura de suspensão
WO2008056779A1 (fr) * 2006-11-09 2008-05-15 Japan As Represented By The President Of International Medical Center Of Japan Procédé destiné à la culture et au passage d'une cellule souche embryonnaire de primate, et procédé destiné à induire la différenciation de la cellule souche embryonnaire
US20090053182A1 (en) * 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
CN104250632B (zh) * 2007-07-01 2018-09-11 生命扫描有限公司 单个多能干细胞培养
GB0800524D0 (en) * 2008-01-14 2008-02-20 Univ Brighton Cell culture system
US8716018B2 (en) * 2008-03-17 2014-05-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
PL2942392T3 (pl) * 2008-06-30 2019-02-28 Janssen Biotech, Inc Różnicowanie pluripotencjalnych komórek macierzystych
US8895300B2 (en) * 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
AU2010283229B2 (en) * 2009-08-12 2015-04-02 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
WO2011158960A1 (en) * 2010-06-15 2011-12-22 Kyoto University Method for selecting human induced pluripotent stem cells
US9085757B2 (en) * 2010-06-17 2015-07-21 Regents Of The University Of Minnesota Production of insulin producing cells
EP3211070A1 (en) * 2010-08-31 2017-08-30 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
MY177150A (en) * 2011-02-28 2020-09-08 Stempeutics Res Malaysia Sdn Bhd Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof
WO2013056072A1 (en) * 2011-10-13 2013-04-18 Wisconsin Alumni Research Foundation Generation of cardiomyocytes from human pluripotent stem cells
RU2705001C2 (ru) * 2011-12-22 2019-11-01 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
US10519422B2 (en) * 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
CA2896750A1 (en) * 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
KR20160079072A (ko) * 2013-11-01 2016-07-05 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 인간 만능 줄기세포의 현탁 및 클러스터링

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