MX2016000783A - Metodos para preparar rotavirus inactivado. - Google Patents

Metodos para preparar rotavirus inactivado.

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Publication number
MX2016000783A
MX2016000783A MX2016000783A MX2016000783A MX2016000783A MX 2016000783 A MX2016000783 A MX 2016000783A MX 2016000783 A MX2016000783 A MX 2016000783A MX 2016000783 A MX2016000783 A MX 2016000783A MX 2016000783 A MX2016000783 A MX 2016000783A
Authority
MX
Mexico
Prior art keywords
rotavirus
inactivated
bovine
methods
temperature
Prior art date
Application number
MX2016000783A
Other languages
English (en)
Other versions
MX366915B (es
Inventor
Brent E Dekker
John M Herbert
Michael J Reimnitz
Original Assignee
Novartis Tiergesundheit Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Tiergesundheit Ag filed Critical Novartis Tiergesundheit Ag
Publication of MX2016000783A publication Critical patent/MX2016000783A/es
Publication of MX366915B publication Critical patent/MX366915B/es

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/15Reoviridae, e.g. calf diarrhea virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12311Rotavirus, e.g. rotavirus A
    • C12N2720/12321Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12311Rotavirus, e.g. rotavirus A
    • C12N2720/12332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12311Rotavirus, e.g. rotavirus A
    • C12N2720/12334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12311Rotavirus, e.g. rotavirus A
    • C12N2720/12361Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

En la presente se describen métodos para producir rotavirus inactivado directamente a partir de sobrenadantes de cultivo celular que contienen rotavirus activos o infecciosos (por ejemplo, rotavirus de origen bovino), sin un aislamiento o purificación previos de dicho rotavirus a partir de los sobrenadantes de cultivo celular. En algunas modalidades, el rotavirus inactivado (por ejemplo, rotavirus de origen bovino) se produce al calentar un volumen de sobrenadante de cultivo a al menos una temperatura a la cual el rotavirus se inactiva. En algunas modalidades, el rotavirus (por ejemplo, rotavirus de origen bovino) se inactiva una vez que el volumen entero se calienta a al menos una temperatura a la cual el rotavirus se inactiva. En algunas modalidades, la temperatura del sobrenadante de cultivo celular se mantiene durante una cantidad de tiempo adecuada, la cual puede determinarse usando cualquiera de las pruebas descritas en la presente. El rotavirus inactivado (por ejemplo, rotavirus de origen bovino) puede posteriormente aislarse del sobrenadante de cultivo.
MX2016000783A 2013-07-19 2014-07-18 Métodos para preparar rotavirus inactivado. MX366915B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361856294P 2013-07-19 2013-07-19
PCT/US2014/047164 WO2015010002A1 (en) 2013-07-19 2014-07-18 Methods for preparing inactivated rotavirus

Publications (2)

Publication Number Publication Date
MX2016000783A true MX2016000783A (es) 2016-04-27
MX366915B MX366915B (es) 2019-07-30

Family

ID=51293170

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000783A MX366915B (es) 2013-07-19 2014-07-18 Métodos para preparar rotavirus inactivado.

Country Status (16)

Country Link
US (1) US10030232B2 (es)
EP (1) EP3021867B1 (es)
JP (1) JP6089150B2 (es)
CN (1) CN105451764B (es)
AU (1) AU2014290523B2 (es)
BR (1) BR112015032773A8 (es)
CA (1) CA2913662C (es)
EA (1) EA038610B1 (es)
ES (1) ES2732301T3 (es)
HK (1) HK1217174A1 (es)
MX (1) MX366915B (es)
NZ (1) NZ714544A (es)
PL (1) PL3021867T3 (es)
PT (1) PT3021867T (es)
WO (1) WO2015010002A1 (es)
ZA (1) ZA201508666B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109355263A (zh) * 2018-12-11 2019-02-19 中国医学科学院医学生物学研究所 利用生物反应器生产轮状病毒的方法
CN114410592B (zh) * 2021-12-30 2024-05-24 苏州百源基因技术有限公司 一种轮状病毒培养基及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101051986B1 (ko) * 2006-09-28 2011-07-26 중앙대학교 산학협력단 인간로타바이러스 및 이를 이용한 백신 조성물
WO2009032913A2 (en) * 2007-09-04 2009-03-12 The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services Thermal inactivation of rotavirus
EP2661277A2 (en) * 2011-01-05 2013-11-13 Bharat Biotech International Limited A combination heptavalent vaccine

Also Published As

Publication number Publication date
EA201592175A1 (ru) 2016-08-31
WO2015010002A1 (en) 2015-01-22
HK1217174A1 (zh) 2016-12-30
JP6089150B2 (ja) 2017-03-01
BR112015032773A8 (pt) 2018-01-23
EP3021867A1 (en) 2016-05-25
US20160145583A1 (en) 2016-05-26
PT3021867T (pt) 2019-06-24
CN105451764A (zh) 2016-03-30
MX366915B (es) 2019-07-30
EA038610B1 (ru) 2021-09-22
AU2014290523B2 (en) 2016-12-08
EP3021867B1 (en) 2019-04-17
CA2913662C (en) 2021-05-04
BR112015032773A2 (pt) 2017-07-25
NZ714544A (en) 2016-11-25
JP2016525120A (ja) 2016-08-22
AU2014290523A1 (en) 2015-12-24
CN105451764B (zh) 2021-04-02
ES2732301T3 (es) 2019-11-21
US10030232B2 (en) 2018-07-24
PL3021867T3 (pl) 2019-09-30
ZA201508666B (en) 2017-07-26
CA2913662A1 (en) 2015-01-22

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