MX2015016033A - Derivados de biciclicos que contienen anillo de pirimidina, y metodo de preparacion de los mismos. - Google Patents

Derivados de biciclicos que contienen anillo de pirimidina, y metodo de preparacion de los mismos.

Info

Publication number
MX2015016033A
MX2015016033A MX2015016033A MX2015016033A MX2015016033A MX 2015016033 A MX2015016033 A MX 2015016033A MX 2015016033 A MX2015016033 A MX 2015016033A MX 2015016033 A MX2015016033 A MX 2015016033A MX 2015016033 A MX2015016033 A MX 2015016033A
Authority
MX
Mexico
Prior art keywords
pyrimidine ring
derivative containing
preparation
method therefor
pharmaceutically acceptable
Prior art date
Application number
MX2015016033A
Other languages
English (en)
Inventor
Young Sim Jae
Hun CHA Myung
Kyun Kim Tae
Ae Yoon Young
Hoon Kim Dong
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of MX2015016033A publication Critical patent/MX2015016033A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona: un derivado bicíclico que comprende un anillo de pirimidina, o una sal farmacéuticamente aceptable del mismo; un método de preparación del mismo, una composición farmacéutica que comprende el mismo; y un uso del mismo. De acuerdo con la presente invención, el derivado del compuesto bicíclico comprende un anillo de pirimidina, o una sal farmacéuticamente aceptable del mismo que actúa como un agonista del receptor 5-HT4, y por lo tanto se puede aplicar de manera útil a la prevención o tratamiento de la disfunción de la motilidad gastrointestinal, por ejemplo, enfermedades gastrointestinales tal como la enfermedad por reflujo gastroesofágico (GERD por sus siglas en inglés), estreñimiento, síndrome del intestino irritable (lBS por sus siglas en inglés), dispepsia, íleo postoperatorio, retraso del vaciado gástrico, gastroparesia, obstrucción pseudo intestinal, tránsito retardado inducido por fármacos, atonía gástrica. diabética y similares.
MX2015016033A 2013-05-24 2014-05-23 Derivados de biciclicos que contienen anillo de pirimidina, y metodo de preparacion de los mismos. MX2015016033A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130058843A KR101657616B1 (ko) 2013-05-24 2013-05-24 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
PCT/KR2014/004636 WO2014189331A1 (ko) 2013-05-24 2014-05-23 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법

Publications (1)

Publication Number Publication Date
MX2015016033A true MX2015016033A (es) 2016-08-03

Family

ID=51933817

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016033A MX2015016033A (es) 2013-05-24 2014-05-23 Derivados de biciclicos que contienen anillo de pirimidina, y metodo de preparacion de los mismos.

Country Status (12)

Country Link
US (1) US20170152241A9 (es)
EP (1) EP3006439A4 (es)
JP (1) JP2016520098A (es)
KR (1) KR101657616B1 (es)
CN (1) CN105452238A (es)
AU (1) AU2014269229B2 (es)
BR (1) BR112015029156A2 (es)
CA (1) CA2913592A1 (es)
HK (1) HK1218536A1 (es)
MX (1) MX2015016033A (es)
RU (1) RU2015155292A (es)
WO (1) WO2014189331A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110317176A (zh) * 2019-07-04 2019-10-11 沈阳药科大学 2-氨基嘧啶类化合物及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CZ284687B6 (cs) 1986-04-30 1999-02-17 Dainippon Pharmaceutical Co., Ltd. Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
HUT64023A (en) 1991-03-22 1993-11-29 Sandoz Ag Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
WO1996005177A1 (en) * 1994-08-13 1996-02-22 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof
US20070027156A1 (en) * 2003-09-09 2007-02-01 Hisao Nakai Crf antagonists and heterobicyclic compounds
JP2009515892A (ja) * 2005-11-14 2009-04-16 バーテックス ファーマシューティカルズ インコーポレイテッド 電位型イオンチャネルモジュレータとして有用なキナゾリン
CN101679440A (zh) * 2007-04-02 2010-03-24 帕劳制药股份有限公司 作为jak3抑制剂的吡咯并嘧啶衍生物
AU2009238590A1 (en) * 2008-04-22 2009-10-29 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
AR073397A1 (es) * 2008-09-23 2010-11-03 Palau Pharma Sa Derivados de (r) -3- (n,n-dimetilamino) pirrolidina
IN2013MN01519A (es) * 2011-02-25 2015-06-12 Yuhan Corp
KR101682417B1 (ko) * 2011-02-25 2016-12-06 주식회사유한양행 다이아미노피리미딘 유도체 및 그의 제조방법
AU2012311184A1 (en) * 2011-09-22 2014-03-06 Pfizer Inc. Pyrrolopyrimidine and purine derivatives

Also Published As

Publication number Publication date
RU2015155292A (ru) 2017-06-30
BR112015029156A2 (pt) 2017-07-25
AU2014269229B2 (en) 2017-03-02
US20160090374A1 (en) 2016-03-31
EP3006439A4 (en) 2016-11-02
HK1218536A1 (zh) 2017-02-24
EP3006439A1 (en) 2016-04-13
CN105452238A (zh) 2016-03-30
JP2016520098A (ja) 2016-07-11
KR20140137810A (ko) 2014-12-03
US20170152241A9 (en) 2017-06-01
WO2014189331A1 (ko) 2014-11-27
AU2014269229A1 (en) 2015-12-17
KR101657616B1 (ko) 2016-09-19
CA2913592A1 (en) 2014-11-27

Similar Documents

Publication Publication Date Title
MX336155B (es) Derivados de diaminopirimidina y procesos para su preparacion.
WO2012115479A3 (en) Diaminopyrimidine derivatives and processes for the preparation thereof
EP3804712A4 (en) PHARMACEUTICAL COMBINATION WITH A GLUCOSE KINASE ACTIVATOR AND PPAR RECEPTOR ACTIVATOR, COMPOSITION, COMPOUND PREPARATION, METHOD OF MANUFACTURE AND USES THEREOF
WO2011097372A3 (en) Pterostilbene cocrystals
WO2007141283A3 (en) Salts and crystalline salt forms of an 2-indolinone derivative
MX2010010407A (es) Derivados de 4-aminociclohexanos sustituidos.
WO2011157721A3 (en) Ivabradine-containing pharmaceutical composition
UA110207C2 (en) Pharmaceutical pill that contains 1- (-d- hlyukopiranozyl) -4-methyl -3- [5- (4-fluorophenyl) -2 inhibitors tiyenilmetyl benzol natriydependent transporter of glucose (nzph)
EA201490161A1 (ru) Соединения - ингибиторы сигналинга, опосредуемого рецептором notch
WO2011045232A3 (en) Neuropeptide-2 receptor (y-2r) agonists
WO2012027392A3 (en) Antimetastatic compounds
EA201300034A1 (ru) Фармацевтические композиции, содержащие иматиниб или его фармацевтически приемлемую соль, и способы их получения
WO2010052144A3 (en) Neuropeptide-2-receptor (y-2r) agonists and uses thereof
EA201370219A1 (ru) Противогипертоническая фармацевтическая композиция
WO2016166720A3 (en) Polymorphs of afatinib and its salts and process for the preparation of quinazolinyl derivatives
WO2012017448A3 (en) Salts of lapatinib
UA112764C2 (uk) Оптимізований синтез чистих, неполіморфних кристалічних жовчних кислот із заданим розміром частинок
EA201590474A1 (ru) ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ОСНОВЕ КОМПОЗИТНЫХ КАПСУЛ, ВКЛЮЧАЮЩИХ ИРБЕСАРТАН И ИНГИБИТОР ГМГ-КоА РЕДУКТАЗЫ
PH12019500567A1 (en) Crystalline forms
MX2015016033A (es) Derivados de biciclicos que contienen anillo de pirimidina, y metodo de preparacion de los mismos.
WO2009124733A8 (de) Substituierte sulfonamid-derivate
WO2012006566A3 (en) Microcrystalline y receptor agonists
WO2010038948A3 (en) Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders
NZ764004A (en) Heteroaryl compounds as muscarinic m1 receptor positive allosteric modulators
WO2013039785A3 (en) Heterocyclic inhibitors of histamine receptors for the treatment of disease