MX2015009858A - Moleculas de administracion selectiva y metodos de uso. - Google Patents
Moleculas de administracion selectiva y metodos de uso.Info
- Publication number
- MX2015009858A MX2015009858A MX2015009858A MX2015009858A MX2015009858A MX 2015009858 A MX2015009858 A MX 2015009858A MX 2015009858 A MX2015009858 A MX 2015009858A MX 2015009858 A MX2015009858 A MX 2015009858A MX 2015009858 A MX2015009858 A MX 2015009858A
- Authority
- MX
- Mexico
- Prior art keywords
- selective delivery
- methods
- delivery molecules
- tissue retention
- sequence
- Prior art date
Links
- 230000014759 maintenance of location Effects 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Radiology & Medical Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paper (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
En el presente documento se divulga una molécula de administración selectiva que comprende: (a) una secuencia ácida (porción A) que es eficaz para inhibir o prevenir la captación en células o la retención en tejido, (b) una secuencia de transporte molecular o retención en tejido (porción B), y (c) un enlazante entre la porción A y la porción B, y (d) restos de carga (porción DA y DB).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361758680P | 2013-01-30 | 2013-01-30 | |
PCT/US2014/013942 WO2014120974A1 (en) | 2013-01-30 | 2014-01-30 | Selective delivery molecules and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015009858A true MX2015009858A (es) | 2016-02-16 |
MX366375B MX366375B (es) | 2019-07-05 |
Family
ID=51262954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015009858A MX366375B (es) | 2013-01-30 | 2014-01-30 | Moleculas de administracion selectiva y metodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (4) | US9782498B2 (es) |
EP (1) | EP2951210A4 (es) |
JP (1) | JP6508781B2 (es) |
KR (2) | KR102363779B1 (es) |
CN (1) | CN105102484B (es) |
AU (1) | AU2014212308B2 (es) |
CA (2) | CA2899448C (es) |
EA (1) | EA031930B1 (es) |
HK (1) | HK1217720A1 (es) |
MX (1) | MX366375B (es) |
WO (1) | WO2014120974A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2403964B1 (en) | 2009-03-02 | 2021-09-08 | Massachusetts Institute of Technology | Methods and products for in vivo enzyme profiling |
ES2881535T3 (es) | 2011-03-15 | 2021-11-29 | Massachusetts Inst Technology | Detección multiplexada con indicadores codificados con isótopos |
AU2012290318B2 (en) | 2011-07-29 | 2016-09-01 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
WO2014120974A1 (en) | 2013-01-30 | 2014-08-07 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
CN118010994A (zh) | 2013-06-07 | 2024-05-10 | 麻省理工学院 | 基于亲和力检测配体编码的合成性生物标记物 |
EP3777978A1 (en) | 2015-08-18 | 2021-02-17 | Rakuten Medical, Inc. | Phthalocyanine dye conjugates and their storage |
JP7085995B2 (ja) | 2015-08-18 | 2022-06-17 | ラクテン・メディカル,インコーポレイテッド | 光免疫療法のための組成物、組み合わせおよび関連方法 |
EP3789395A1 (en) | 2015-11-23 | 2021-03-10 | Bristol-Myers Squibb Company | Pegylation of fgf21 |
WO2017177115A1 (en) | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
CA3022928A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
AU2018248327A1 (en) | 2017-04-07 | 2019-10-17 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
US20220347306A1 (en) * | 2018-04-16 | 2022-11-03 | Avelas Biosciences, Inc. | Selective delivery of therapeutic and imaging agents |
WO2020150560A1 (en) | 2019-01-17 | 2020-07-23 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
US20220160871A1 (en) | 2019-03-29 | 2022-05-26 | Rakuten Medical, Inc. | Methods for photoimmunotherapy and related biomarkers |
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US4452720A (en) | 1980-06-04 | 1984-06-05 | Teijin Limited | Fluorescent composition having the ability to change wavelengths of light, shaped article of said composition as a light wavelength converting element and device for converting optical energy to electrical energy using said element |
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US4496542A (en) | 1981-03-30 | 1985-01-29 | Usv Pharmaceutical Corporation | N-substituted-amido-amino acids |
US4507389A (en) | 1982-12-16 | 1985-03-26 | Monsanto Company | Determination of collagenase by reacting with peptide substrates |
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JP5580625B2 (ja) | 2010-03-03 | 2014-08-27 | 住友化学株式会社 | メタンスルホン酸アルキルエステル溶液の製造方法 |
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JP6486003B2 (ja) * | 2011-02-10 | 2019-03-20 | ルプレヒト−カールス−ウニヴェルジテート ハイデルベルクRuprecht−Karls−Universitaet Heidelberg | 肝臓特異的診断のための疎水性修飾ペプチド |
AU2012290318B2 (en) * | 2011-07-29 | 2016-09-01 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
WO2014120837A2 (en) | 2013-01-29 | 2014-08-07 | The Regents Of The University Of California | Pretargeted activatable cell penetrating peptide with intracellulary releaseable prodrug |
WO2014120974A1 (en) * | 2013-01-30 | 2014-08-07 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
EP2988786A4 (en) | 2013-04-22 | 2016-12-21 | Avelas Biosciences Inc | COMPOSITIONS AND METHODS OF USE FOR SELECTIVE DRUG DELIVERY |
-
2014
- 2014-01-30 WO PCT/US2014/013942 patent/WO2014120974A1/en active Application Filing
- 2014-01-30 JP JP2015556140A patent/JP6508781B2/ja not_active Expired - Fee Related
- 2014-01-30 US US14/764,681 patent/US9782498B2/en active Active
- 2014-01-30 EP EP14746840.9A patent/EP2951210A4/en active Pending
- 2014-01-30 CA CA2899448A patent/CA2899448C/en active Active
- 2014-01-30 KR KR1020217021841A patent/KR102363779B1/ko active IP Right Grant
- 2014-01-30 AU AU2014212308A patent/AU2014212308B2/en active Active
- 2014-01-30 CA CA3128911A patent/CA3128911C/en active Active
- 2014-01-30 CN CN201480019153.9A patent/CN105102484B/zh active Active
- 2014-01-30 KR KR1020157022729A patent/KR102278630B1/ko active IP Right Grant
- 2014-01-30 MX MX2015009858A patent/MX366375B/es active IP Right Grant
- 2014-01-30 EA EA201591284A patent/EA031930B1/ru unknown
-
2016
- 2016-05-20 HK HK16105781.4A patent/HK1217720A1/zh unknown
-
2017
- 2017-08-24 US US15/685,942 patent/US10226539B2/en active Active
-
2019
- 2019-01-31 US US16/264,296 patent/US11052160B2/en active Active
-
2021
- 2021-05-03 US US17/302,453 patent/US20220257800A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2899448A1 (en) | 2014-08-07 |
KR102278630B1 (ko) | 2021-07-16 |
HK1217720A1 (zh) | 2017-01-20 |
WO2014120974A1 (en) | 2014-08-07 |
US11052160B2 (en) | 2021-07-06 |
CN105102484A (zh) | 2015-11-25 |
US20190151481A1 (en) | 2019-05-23 |
CN105102484B (zh) | 2020-03-10 |
US20150359908A1 (en) | 2015-12-17 |
US10226539B2 (en) | 2019-03-12 |
KR20150111963A (ko) | 2015-10-06 |
US20180000971A1 (en) | 2018-01-04 |
CA3128911C (en) | 2023-10-17 |
JP6508781B2 (ja) | 2019-05-08 |
EP2951210A1 (en) | 2015-12-09 |
MX366375B (es) | 2019-07-05 |
US20220257800A1 (en) | 2022-08-18 |
KR102363779B1 (ko) | 2022-02-15 |
JP2016516000A (ja) | 2016-06-02 |
CA2899448C (en) | 2021-10-26 |
CA3128911A1 (en) | 2014-08-07 |
US9782498B2 (en) | 2017-10-10 |
KR20210090739A (ko) | 2021-07-20 |
EA031930B1 (ru) | 2019-03-29 |
AU2014212308A1 (en) | 2015-08-13 |
AU2014212308B2 (en) | 2018-08-09 |
EP2951210A4 (en) | 2016-09-21 |
EA201591284A1 (ru) | 2016-04-29 |
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