MX2015009404A - Peptidos bioactivos cortos que promueven la cicatrizacion de las heridas. - Google Patents
Peptidos bioactivos cortos que promueven la cicatrizacion de las heridas.Info
- Publication number
- MX2015009404A MX2015009404A MX2015009404A MX2015009404A MX2015009404A MX 2015009404 A MX2015009404 A MX 2015009404A MX 2015009404 A MX2015009404 A MX 2015009404A MX 2015009404 A MX2015009404 A MX 2015009404A MX 2015009404 A MX2015009404 A MX 2015009404A
- Authority
- MX
- Mexico
- Prior art keywords
- peptides
- disclosed
- mpkekvflkiekmgrnirn
- peptide
- amino acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Insects & Arthropods (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
Abstract
En la presente se describen péptidos que comprenden entre cuatro y seis residuos de aminoácidos y que presentan actividad biológica, que son fragmentos cortos del péptido HB-107 (MPKEKVFLKIEKMGRNIRN), que a su vez es un fragmento de la proteína antimicrobiana cecropina B, y que presentan propiedades relacionadas con la estimulación de la proliferación y la migración de las células. Los péptidos de acuerdo con la presente invención comprenden entre cuatro y seis residuos de aminoácidos contiguos, que están localizados entre las posiciones 11 y 16 de HB107 (MPKEKVFLKIEKMGRNIRN), es decir, EKMGRN, y son agentes útiles para llevar a cabo el tratamiento médico de las heridas en la piel, que por ejemplo, pueden deberse a úlceras diabéticas. Los péptidos también son eficaces para prevenir y revertir el daño en la superficie de la piel que ha sido provocado por diversos factores ambientales. Vale destacar que los efectos terapéuticos de los péptidos de acuerdo con la presente invención se manifiestan en concentraciones iguales o superiores a las que serían necesarias si se empleara el péptido HB-107, por lo que estos péptidos representan un medio más económico y más versátil para desarrollar terapias eficaces. En la presente también se describen métodos con los que pueden producirse y usarse los péptidos de acuerdo con la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764913P | 2013-02-14 | 2013-02-14 | |
| PCT/US2014/012378 WO2014126681A1 (en) | 2013-02-14 | 2014-01-21 | Short bio-active peptides for promoting wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015009404A true MX2015009404A (es) | 2016-10-07 |
| MX363955B MX363955B (es) | 2019-04-08 |
Family
ID=50069319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015009404A MX363955B (es) | 2013-02-14 | 2014-01-21 | Peptidos bioactivos cortos que promueven la cicatrizacion de las heridas. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9487558B2 (es) |
| EP (1) | EP2956155B1 (es) |
| JP (1) | JP6348126B2 (es) |
| KR (1) | KR101894829B1 (es) |
| CN (1) | CN105120884B (es) |
| AR (1) | AR094835A1 (es) |
| AU (1) | AU2014216730B2 (es) |
| BR (1) | BR112015019568A2 (es) |
| CA (1) | CA2898717C (es) |
| CY (1) | CY1119087T1 (es) |
| DK (1) | DK2956155T3 (es) |
| ES (1) | ES2633437T3 (es) |
| HK (1) | HK1212243A1 (es) |
| HU (1) | HUE033976T2 (es) |
| MX (1) | MX363955B (es) |
| MY (1) | MY173174A (es) |
| NZ (1) | NZ711281A (es) |
| PL (1) | PL2956155T3 (es) |
| RU (1) | RU2606753C1 (es) |
| SG (1) | SG11201505538QA (es) |
| SI (1) | SI2956155T1 (es) |
| TW (1) | TWI587867B (es) |
| WO (1) | WO2014126681A1 (es) |
| ZA (1) | ZA201505516B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201808804TA (en) * | 2016-04-08 | 2018-11-29 | Univ Cornell | A method to enhance wound healing using silk-derived protein |
| EP3312608B1 (en) * | 2016-10-24 | 2019-10-02 | Akribes Biomedical GmbH | Methods for identifying a non-healing skin wound and for monitoring the healing of a skin wound |
| US10232009B1 (en) * | 2017-09-29 | 2019-03-19 | Pro Sunfun Biotech Research And Development Co., Ltd. | Peptide for promoting wound healing, its composition and method of using the same |
| CN108586575B (zh) * | 2018-04-11 | 2020-08-14 | 福建省中科生物股份有限公司 | 一种多肽及其皮肤修复功能的应用 |
| CZ308845B6 (cs) * | 2019-01-21 | 2021-07-07 | Globetech Innovation S.R.O | Farmaceutická směs topicky hojivých peptidových složek pro použití k topické léčbě kožních defektů a/nebo k topickému hojení ran |
| CN116407611A (zh) * | 2021-12-29 | 2023-07-11 | 四川好医生攀西药业有限责任公司 | 一种多肽在制备预防或治疗皮肤损伤疾病产品上的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6360939A (ja) * | 1986-08-29 | 1988-03-17 | Shin Etsu Chem Co Ltd | 抗菌物質 |
| AU2132088A (en) | 1987-07-06 | 1989-01-30 | Louisiana State University Agricultural And Mechanical College | Inhibition of eucaryotic pathogens and neoplasms and stimulation of fibroblasts and lymphocytes with lytic peptides |
| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| SI2409988T1 (sl) | 2006-06-13 | 2015-10-30 | Helix Biomedix Inc. | Peptidni fragmenti za sprožitev sinteze proteinov zunajcelične matrice |
| WO2008085494A1 (en) * | 2007-01-05 | 2008-07-17 | Helix Biomedix Inc. | Short bio-active peptides for cellular and immunological modulation |
| RU2447896C1 (ru) * | 2010-11-15 | 2012-04-20 | Общество с ограниченной ответственностью "Аллофарм" | Антимикробное вещество |
| US9040662B2 (en) * | 2011-08-25 | 2015-05-26 | University Of Central Florida Research Foundation | Methods and compositions comprising a C-terminal Bax peptide |
-
2014
- 2014-01-21 CA CA2898717A patent/CA2898717C/en active Active
- 2014-01-21 BR BR112015019568A patent/BR112015019568A2/pt not_active Application Discontinuation
- 2014-01-21 RU RU2015138925A patent/RU2606753C1/ru not_active IP Right Cessation
- 2014-01-21 SG SG11201505538QA patent/SG11201505538QA/en unknown
- 2014-01-21 MX MX2015009404A patent/MX363955B/es active IP Right Grant
- 2014-01-21 WO PCT/US2014/012378 patent/WO2014126681A1/en active Application Filing
- 2014-01-21 DK DK14703220.5T patent/DK2956155T3/en active
- 2014-01-21 SI SI201430277T patent/SI2956155T1/sl unknown
- 2014-01-21 EP EP14703220.5A patent/EP2956155B1/en active Active
- 2014-01-21 CN CN201480009001.0A patent/CN105120884B/zh active Active
- 2014-01-21 MY MYPI2015702327A patent/MY173174A/en unknown
- 2014-01-21 KR KR1020157024070A patent/KR101894829B1/ko active IP Right Grant
- 2014-01-21 ES ES14703220.5T patent/ES2633437T3/es active Active
- 2014-01-21 US US14/762,407 patent/US9487558B2/en active Active
- 2014-01-21 NZ NZ711281A patent/NZ711281A/en not_active IP Right Cessation
- 2014-01-21 AU AU2014216730A patent/AU2014216730B2/en not_active Ceased
- 2014-01-21 JP JP2015558016A patent/JP6348126B2/ja active Active
- 2014-01-21 PL PL14703220T patent/PL2956155T3/pl unknown
- 2014-01-21 HU HUE14703220A patent/HUE033976T2/en unknown
- 2014-01-29 TW TW103103686A patent/TWI587867B/zh not_active IP Right Cessation
- 2014-02-14 AR ARP140100481A patent/AR094835A1/es unknown
-
2015
- 2015-07-31 ZA ZA2015/05516A patent/ZA201505516B/en unknown
-
2016
- 2016-01-13 HK HK16100340.9A patent/HK1212243A1/xx unknown
- 2016-09-20 US US15/270,186 patent/US20170000848A1/en not_active Abandoned
-
2017
- 2017-07-14 CY CY20171100747T patent/CY1119087T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20170000848A1 (en) | 2017-01-05 |
| CY1119087T1 (el) | 2018-01-10 |
| AU2014216730A1 (en) | 2015-08-20 |
| CN105120884B (zh) | 2017-08-29 |
| NZ711281A (en) | 2017-12-22 |
| WO2014126681A1 (en) | 2014-08-21 |
| EP2956155B1 (en) | 2017-04-19 |
| US9487558B2 (en) | 2016-11-08 |
| EP2956155A1 (en) | 2015-12-23 |
| HUE033976T2 (en) | 2018-02-28 |
| ZA201505516B (en) | 2016-10-26 |
| JP6348126B2 (ja) | 2018-06-27 |
| DK2956155T3 (en) | 2017-07-31 |
| HK1212243A1 (en) | 2016-06-10 |
| JP2016513107A (ja) | 2016-05-12 |
| TWI587867B (zh) | 2017-06-21 |
| PL2956155T3 (pl) | 2017-09-29 |
| AU2014216730B2 (en) | 2015-12-17 |
| KR20150116883A (ko) | 2015-10-16 |
| SI2956155T1 (sl) | 2017-10-30 |
| BR112015019568A2 (pt) | 2017-08-22 |
| KR101894829B1 (ko) | 2018-09-05 |
| MY173174A (en) | 2020-01-02 |
| ES2633437T3 (es) | 2017-09-21 |
| AR094835A1 (es) | 2015-09-02 |
| RU2606753C1 (ru) | 2017-01-10 |
| CA2898717A1 (en) | 2014-08-21 |
| US20150353605A1 (en) | 2015-12-10 |
| CN105120884A (zh) | 2015-12-02 |
| TW201446258A (zh) | 2014-12-16 |
| MX363955B (es) | 2019-04-08 |
| SG11201505538QA (en) | 2015-08-28 |
| CA2898717C (en) | 2019-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |