MX2015006592A - Terapia de combinacion con volasertib. - Google Patents
Terapia de combinacion con volasertib.Info
- Publication number
- MX2015006592A MX2015006592A MX2015006592A MX2015006592A MX2015006592A MX 2015006592 A MX2015006592 A MX 2015006592A MX 2015006592 A MX2015006592 A MX 2015006592A MX 2015006592 A MX2015006592 A MX 2015006592A MX 2015006592 A MX2015006592 A MX 2015006592A
- Authority
- MX
- Mexico
- Prior art keywords
- day
- aml
- effective amount
- volasertib
- treatment cycle
- Prior art date
Links
- 229950003081 volasertib Drugs 0.000 title claims abstract description 51
- SXNJFOWDRLKDSF-STROYTFGSA-N volasertib Chemical compound C1CN([C@H]2CC[C@@H](CC2)NC(=O)C2=CC=C(C(=C2)OC)NC=2N=C3N(C(C)C)[C@@H](C(N(C)C3=CN=2)=O)CC)CCN1CC1CC1 SXNJFOWDRLKDSF-STROYTFGSA-N 0.000 title claims abstract description 50
- 238000002648 combination therapy Methods 0.000 title description 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims abstract description 87
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims abstract description 39
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims abstract description 31
- 229960000684 cytarabine Drugs 0.000 claims abstract description 29
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims abstract description 29
- 229960000390 fludarabine Drugs 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 27
- VNTHYLVDGVBPOU-QQYBVWGSSA-N (7s,9s)-9-acetyl-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 VNTHYLVDGVBPOU-QQYBVWGSSA-N 0.000 claims abstract description 17
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims abstract description 9
- 238000011282 treatment Methods 0.000 claims description 56
- 150000004677 hydrates Chemical class 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 19
- 229960003334 daunorubicin citrate Drugs 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract description 29
- 238000002347 injection Methods 0.000 abstract description 10
- 239000007924 injection Substances 0.000 abstract description 10
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 1
- 229940052372 daunorubicin citrate liposome Drugs 0.000 abstract 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 83
- 238000011284 combination treatment Methods 0.000 description 13
- 208000032839 leukemia Diseases 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
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- 210000001185 bone marrow Anatomy 0.000 description 7
- 238000001802 infusion Methods 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000007918 intramuscular administration Methods 0.000 description 5
- 238000007912 intraperitoneal administration Methods 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- 208000036566 Erythroleukaemia Diseases 0.000 description 4
- 208000021841 acute erythroid leukemia Diseases 0.000 description 4
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- 239000000969 carrier Substances 0.000 description 4
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- 108010029961 Filgrastim Proteins 0.000 description 3
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- 229920001223 polyethylene glycol Polymers 0.000 description 3
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- 208000016557 Acute basophilic leukemia Diseases 0.000 description 2
- 206010000830 Acute leukaemia Diseases 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
- 208000021494 Acute myeloid leukemia with CEBPA somatic mutations Diseases 0.000 description 2
- 208000037532 Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) Diseases 0.000 description 2
- 208000010581 Acute myeloid leukemia with minimal differentiation Diseases 0.000 description 2
- 206010000890 Acute myelomonocytic leukaemia Diseases 0.000 description 2
- 208000016585 Acute panmyelosis with myelofibrosis Diseases 0.000 description 2
- 208000033775 Basophilic Acute Leukemia Diseases 0.000 description 2
- 206010008583 Chloroma Diseases 0.000 description 2
- 201000010374 Down Syndrome Diseases 0.000 description 2
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 2
- 102000015617 Janus Kinases Human genes 0.000 description 2
- 108010024121 Janus Kinases Proteins 0.000 description 2
- 108010062867 Lenograstim Proteins 0.000 description 2
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 2
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 description 2
- 102000038030 PI3Ks Human genes 0.000 description 2
- 108091007960 PI3Ks Proteins 0.000 description 2
- 108091008121 PML-RARA Proteins 0.000 description 2
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 108091008611 Protein Kinase B Proteins 0.000 description 2
- 101710140204 Signal transducer and transcription activator Proteins 0.000 description 2
- 208000008963 Transient myeloproliferative syndrome Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 description 2
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 description 2
- 208000026784 acute myeloblastic leukemia with maturation Diseases 0.000 description 2
- 208000010816 acute myeloblastic leukemia without maturation Diseases 0.000 description 2
- 208000020683 acute myeloid leukemia with mutated NPM1 Diseases 0.000 description 2
- 208000019159 acute myeloid leukemia with t(6;9)(p23;q34) Diseases 0.000 description 2
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 230000002559 cytogenic effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229960002618 lenograstim Drugs 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 208000022744 myeloid leukemia associated with Down Syndrome Diseases 0.000 description 2
- 201000005987 myeloid sarcoma Diseases 0.000 description 2
- 229940029345 neupogen Drugs 0.000 description 2
- 108010044644 pegfilgrastim Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- WEVWMDXKENHVCZ-UHFFFAOYSA-N 3,4-dihydro-1h-pteridin-2-one Chemical class C1=CN=C2NC(=O)NCC2=N1 WEVWMDXKENHVCZ-UHFFFAOYSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 208000026661 Acute myeloid leukemia with 11q23 abnormalities Diseases 0.000 description 1
- 206010008805 Chromosomal abnormalities Diseases 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102100034583 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 101000590272 Homo sapiens 26S proteasome non-ATPase regulatory subunit 2 Proteins 0.000 description 1
- 101000848781 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 Proteins 0.000 description 1
- 101001092185 Homo sapiens Regulator of cell cycle RGCC Proteins 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000337007 Oceania Species 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 description 1
- 102100035542 Regulator of cell cycle RGCC Human genes 0.000 description 1
- 102000000505 Ribonucleotide Reductases Human genes 0.000 description 1
- 108010041388 Ribonucleotide Reductases Proteins 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- -1 Volasertib compound Chemical class 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- RHZUVFJBSILHOK-UHFFFAOYSA-N anthracen-1-ylmethanolate Chemical compound C1=CC=C2C=C3C(C[O-])=CC=CC3=CC2=C1 RHZUVFJBSILHOK-UHFFFAOYSA-N 0.000 description 1
- 239000003830 anthracite Substances 0.000 description 1
- 229940045799 anthracyclines and related substance Drugs 0.000 description 1
- 230000000719 anti-leukaemic effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 229940107841 daunoxome Drugs 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000012774 diagnostic algorithm Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229960004177 filgrastim Drugs 0.000 description 1
- 229960005304 fludarabine phosphate Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000011368 intensive chemotherapy Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- SXNJFOWDRLKDSF-XKHVUIRMSA-N n-[4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7r)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7h-pteridin-2-yl]amino]-3-methoxybenzamide Chemical compound CC(C)N([C@@H](C(N(C)C1=CN=2)=O)CC)C1=NC=2NC(C(=C1)OC)=CC=C1C(=O)NC(CC1)CCC1N(CC1)CCN1CC1CC1 SXNJFOWDRLKDSF-XKHVUIRMSA-N 0.000 description 1
- 229940071846 neulasta Drugs 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
- HQQSBEDKMRHYME-UHFFFAOYSA-N pefloxacin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 HQQSBEDKMRHYME-UHFFFAOYSA-N 0.000 description 1
- 229960001373 pegfilgrastim Drugs 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195162 | 2012-11-30 | ||
| PCT/EP2013/074862 WO2014083058A1 (en) | 2012-11-30 | 2013-11-27 | Combination therapy with volasertib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015006592A true MX2015006592A (es) | 2015-08-05 |
Family
ID=47325907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015006592A MX2015006592A (es) | 2012-11-30 | 2013-11-27 | Terapia de combinacion con volasertib. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20140154304A1 (OSRAM) |
| EP (1) | EP2925343A1 (OSRAM) |
| JP (1) | JP2016501208A (OSRAM) |
| KR (1) | KR20150090091A (OSRAM) |
| CN (1) | CN104812400A (OSRAM) |
| AU (1) | AU2013351180A1 (OSRAM) |
| BR (1) | BR112015011748A2 (OSRAM) |
| CA (1) | CA2889787A1 (OSRAM) |
| CL (1) | CL2015001258A1 (OSRAM) |
| EA (1) | EA201500579A1 (OSRAM) |
| IL (1) | IL238174A0 (OSRAM) |
| IN (1) | IN2015DN03075A (OSRAM) |
| MX (1) | MX2015006592A (OSRAM) |
| PH (1) | PH12015501113A1 (OSRAM) |
| WO (1) | WO2014083058A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9867831B2 (en) * | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
| CN104306336B (zh) * | 2014-11-18 | 2016-08-24 | 河北天成药业股份有限公司 | 枸橼酸柔红霉素脂质体注射液的制备工艺 |
| HK1258724A1 (zh) * | 2015-11-11 | 2019-11-15 | Celator Pharmaceuticals, Inc. | 选择白血病对象的治疗方案的分析和方法 |
| US20230201202A1 (en) * | 2020-05-27 | 2023-06-29 | Duke University | Compositions and methods for sensitizing acute myeloid leukemias to chemotherapy |
| CN116785296B (zh) * | 2023-06-06 | 2025-09-05 | 河北渤腾医药技术有限公司 | 一种plk1的抑制剂及其应用 |
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| CA2517020C (en) | 2003-02-26 | 2012-06-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, method for the production and use thereof in the form of drugs |
| US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US20100136029A1 (en) * | 2006-12-20 | 2010-06-03 | Universitatsklinikum Hamburg-Eppendorf | Use of Tri-Substituted Glycerol Compounds for the Treatment of Hematological Malignancies |
| AU2008216083B2 (en) * | 2007-02-16 | 2014-02-06 | Jazz Pharmaceuticals Therapeutics, Inc. | Fixed drug ratios for treatment of hematopoietic cancers and proliferative disorders |
| US9358233B2 (en) * | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
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- 2013-11-27 KR KR1020157014213A patent/KR20150090091A/ko not_active Withdrawn
- 2013-11-27 BR BR112015011748A patent/BR112015011748A2/pt not_active IP Right Cessation
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- 2013-11-27 JP JP2015544453A patent/JP2016501208A/ja active Pending
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| CN104812400A (zh) | 2015-07-29 |
| JP2016501208A (ja) | 2016-01-18 |
| WO2014083058A1 (en) | 2014-06-05 |
| KR20150090091A (ko) | 2015-08-05 |
| US20140154304A1 (en) | 2014-06-05 |
| US20170173023A1 (en) | 2017-06-22 |
| EP2925343A1 (en) | 2015-10-07 |
| IN2015DN03075A (OSRAM) | 2015-10-02 |
| CL2015001258A1 (es) | 2015-10-02 |
| PH12015501113A1 (en) | 2015-08-17 |
| CA2889787A1 (en) | 2014-06-05 |
| IL238174A0 (en) | 2015-05-31 |
| BR112015011748A2 (pt) | 2017-07-11 |
| AU2013351180A1 (en) | 2015-04-30 |
| EA201500579A1 (ru) | 2015-12-30 |
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