CL2015001258A1 - Uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina, y uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina y citrato de daunorrubicina, para el tratamiento de la leucemia mieloide aguda (aml); composicion faramceutica. - Google Patents

Uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina, y uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina y citrato de daunorrubicina, para el tratamiento de la leucemia mieloide aguda (aml); composicion faramceutica.

Info

Publication number
CL2015001258A1
CL2015001258A1 CL2015001258A CL2015001258A CL2015001258A1 CL 2015001258 A1 CL2015001258 A1 CL 2015001258A1 CL 2015001258 A CL2015001258 A CL 2015001258A CL 2015001258 A CL2015001258 A CL 2015001258A CL 2015001258 A1 CL2015001258 A1 CL 2015001258A1
Authority
CL
Chile
Prior art keywords
volasertib
gcsf
fludarabine
cytarabine
association
Prior art date
Application number
CL2015001258A
Other languages
English (en)
Inventor
Tilmann Taube
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2015001258A1 publication Critical patent/CL2015001258A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
CL2015001258A 2012-11-30 2015-05-11 Uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina, y uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina y citrato de daunorrubicina, para el tratamiento de la leucemia mieloide aguda (aml); composicion faramceutica. CL2015001258A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12195162 2012-11-30

Publications (1)

Publication Number Publication Date
CL2015001258A1 true CL2015001258A1 (es) 2015-10-02

Family

ID=47325907

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015001258A CL2015001258A1 (es) 2012-11-30 2015-05-11 Uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina, y uso combinado de volasertib en asociacion con gcsf, fludarabina, citarabina y citrato de daunorrubicina, para el tratamiento de la leucemia mieloide aguda (aml); composicion faramceutica.

Country Status (15)

Country Link
US (2) US20140154304A1 (es)
EP (1) EP2925343A1 (es)
JP (1) JP2016501208A (es)
KR (1) KR20150090091A (es)
CN (1) CN104812400A (es)
AU (1) AU2013351180A1 (es)
BR (1) BR112015011748A2 (es)
CA (1) CA2889787A1 (es)
CL (1) CL2015001258A1 (es)
EA (1) EA201500579A1 (es)
IL (1) IL238174A0 (es)
IN (1) IN2015DN03075A (es)
MX (1) MX2015006592A (es)
PH (1) PH12015501113A1 (es)
WO (1) WO2014083058A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867831B2 (en) * 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
CN104306336B (zh) * 2014-11-18 2016-08-24 河北天成药业股份有限公司 枸橼酸柔红霉素脂质体注射液的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52386B (en) 2003-02-26 2013-02-28 Boehringer Ingelheim Pharma Gmbh & Co.Kg. DIHYDROPTERIDINONE, PROCEDURE FOR THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINE
US20060035903A1 (en) 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US7439358B2 (en) 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
ES2396718T3 (es) * 2006-12-20 2013-02-25 Alphaptose Gmbh Uso de compuestos de glicerol tri-sustituidos para el tratamiento de neoplasias malignas
DK3300601T3 (da) * 2007-02-16 2022-03-21 Rotalec Ip Holdings Llc Faste lægemiddelforhold til behandling af hæmatopoietiske kræftformer og proliferative lidelser
US9358233B2 (en) * 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia

Also Published As

Publication number Publication date
CA2889787A1 (en) 2014-06-05
IN2015DN03075A (es) 2015-10-02
WO2014083058A1 (en) 2014-06-05
US20170173023A1 (en) 2017-06-22
US20140154304A1 (en) 2014-06-05
BR112015011748A2 (pt) 2017-07-11
EP2925343A1 (en) 2015-10-07
CN104812400A (zh) 2015-07-29
AU2013351180A1 (en) 2015-04-30
PH12015501113A1 (en) 2015-08-17
EA201500579A1 (ru) 2015-12-30
IL238174A0 (en) 2015-05-31
KR20150090091A (ko) 2015-08-05
MX2015006592A (es) 2015-08-05
JP2016501208A (ja) 2016-01-18

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