MX2015005328A - Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas. - Google Patents

Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas.

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Publication number
MX2015005328A
MX2015005328A MX2015005328A MX2015005328A MX2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A
Authority
MX
Mexico
Prior art keywords
nucleic acid
cells
oligonucleotid
molecules
compositions
Prior art date
Application number
MX2015005328A
Other languages
English (en)
Spanish (es)
Inventor
Maria Del Carmen Carmona Orozco
Andrés Pablo Montefeltro
Gabriel G Alvarado
Analia Bortolozzi
Raquel Revilla-Sanchez
Original Assignee
Nlife Therapeutics S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nlife Therapeutics S L filed Critical Nlife Therapeutics S L
Publication of MX2015005328A publication Critical patent/MX2015005328A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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MX2015005328A 2012-10-26 2013-10-25 Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas. MX2015005328A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719297P 2012-10-26 2012-10-26
EP12382413 2012-10-26
PCT/EP2013/072411 WO2014064258A1 (en) 2012-10-26 2013-10-25 Compositions and methods for selective delivery of oligonucleotide molecules to cell types

Publications (1)

Publication Number Publication Date
MX2015005328A true MX2015005328A (es) 2015-09-25

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MX2015005328A MX2015005328A (es) 2012-10-26 2013-10-25 Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas.

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US (3) US9938525B2 (enExample)
EP (1) EP2911697A1 (enExample)
JP (1) JP2016503394A (enExample)
AU (1) AU2013336582A1 (enExample)
CA (1) CA2889608A1 (enExample)
MX (1) MX2015005328A (enExample)
WO (1) WO2014064258A1 (enExample)

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