MX2014014710A - Compuestos de n-alquiltriazol como antagonistas del receptor del acido lisofosfatidico (lpar). - Google Patents

Compuestos de n-alquiltriazol como antagonistas del receptor del acido lisofosfatidico (lpar).

Info

Publication number
MX2014014710A
MX2014014710A MX2014014710A MX2014014710A MX2014014710A MX 2014014710 A MX2014014710 A MX 2014014710A MX 2014014710 A MX2014014710 A MX 2014014710A MX 2014014710 A MX2014014710 A MX 2014014710A MX 2014014710 A MX2014014710 A MX 2014014710A
Authority
MX
Mexico
Prior art keywords
compounds
alkyltriazole
lpar antagonists
lpar
antagonists
Prior art date
Application number
MX2014014710A
Other languages
English (en)
Spanish (es)
Inventor
Matthew C Lucas
Yimin Qian
Matthew Michael Hamilton
Achyutharao Sidduri
Stephen Deems Gabriel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014014710(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014014710A publication Critical patent/MX2014014710A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
MX2014014710A 2012-06-20 2013-06-17 Compuestos de n-alquiltriazol como antagonistas del receptor del acido lisofosfatidico (lpar). MX2014014710A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
MX2014014710A true MX2014014710A (es) 2015-03-04

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014710A MX2014014710A (es) 2012-06-20 2013-06-17 Compuestos de n-alquiltriazol como antagonistas del receptor del acido lisofosfatidico (lpar).

Country Status (22)

Country Link
US (1) US9321738B2 (ru)
EP (1) EP2864300A1 (ru)
JP (1) JP2015520202A (ru)
KR (1) KR20150021057A (ru)
CN (1) CN104411692A (ru)
AU (1) AU2013279512A1 (ru)
BR (1) BR112014030685A2 (ru)
CA (1) CA2869541A1 (ru)
CL (1) CL2014003243A1 (ru)
CO (1) CO7131358A2 (ru)
CR (1) CR20140525A (ru)
EA (1) EA201492285A1 (ru)
HK (1) HK1206342A1 (ru)
IL (1) IL236088A0 (ru)
IN (1) IN2014DN09348A (ru)
MA (1) MA37764A1 (ru)
MX (1) MX2014014710A (ru)
PE (1) PE20142448A1 (ru)
PH (1) PH12014502789A1 (ru)
SG (1) SG11201407220YA (ru)
UA (1) UA109868C2 (ru)
WO (1) WO2013189864A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2744807A4 (en) 2011-08-15 2015-03-04 Intermune Inc COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS
MX2014014711A (es) * 2012-06-20 2015-03-04 Hoffmann La Roche Compuestos de n-ariltriazol como antagonistas del receptor de acido lisofosfatidico (lpar).
MX2015013303A (es) 2013-03-15 2015-12-15 Epigen Biosciences Inc Compuestos heterociclicos utiles para el tratamiento de una enfermedad.
CA2953472C (en) 2014-06-27 2022-08-02 Ube Industries, Ltd. Halogen-substituted heterocyclic compound salt
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
EP3727589B1 (en) 2017-12-19 2022-06-29 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azoles as lpa antagonists
WO2019126089A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azines as lpa antagonists
WO2019126086A1 (en) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as lpa antagonists
WO2019126084A1 (en) * 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
ES2943661T3 (es) 2017-12-19 2023-06-15 Bristol Myers Squibb Co Acidos carbamoil ciclohexílicos pirazol-O-ligados como antagonistas de LPA
US11319315B2 (en) 2017-12-19 2022-05-03 Bristol-Myers Squibb Company Cyclohexyl acid triazole azoles as LPA antagonists
US11261180B2 (en) 2017-12-19 2022-03-01 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azoles as LPA antagonists
BR112020011965A2 (pt) 2017-12-19 2020-11-17 Bristol-Myers Squibb Company triazol azinas de ácido ciclo-hexílico como antagonistas de lpa
LT3710438T (lt) * 2017-12-19 2021-12-27 Bristol-Myers Squibb Company Triazolo per n prijungtos karbamoilcikloheksilo rūgštys kaip lpa antagonistai
MX2020005874A (es) 2017-12-19 2020-08-13 Bristol Myers Squibb Co Acidos carbamoil ciclohexilicos n-enlazados a pirazol como antagonistas de receptores del acido lisofosfatidico (lpa).
KR20200100724A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 이속사졸 n-연결된 카르바모일 시클로헥실 산
CN117069712A (zh) * 2017-12-29 2023-11-17 生物马林药物股份有限公司 用于疾病治疗的乙醇酸氧化酶抑制剂
WO2020060915A1 (en) * 2018-09-18 2020-03-26 Bristol-Myers Squibb Company Cyclopentyl acids as lpa antagonists
CN113366000A (zh) * 2018-09-18 2021-09-07 百时美施贵宝公司 作为lpa拮抗剂的氧杂双环酸
ES2948793T3 (es) * 2018-09-18 2023-09-19 Bristol Myers Squibb Co Acidos cicloheptílicos como antagonistas de LPA
CA3158743A1 (en) * 2019-11-15 2021-05-20 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
TW202344504A (zh) 2020-06-03 2023-11-16 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
AU2021282986B2 (en) 2020-06-03 2024-03-07 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (en) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist and uses thereof
WO2011159633A1 (en) 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Inhalable formulations of lysophosphatdic acid receptor antagonists
PE20140879A1 (es) * 2010-12-07 2014-08-06 Amira Pharmaceuticals Inc Antagonistas del receptor de acido lisofosfatidico para el tratamiento de fibrosis
WO2012138648A1 (en) 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
EP2744807A4 (en) * 2011-08-15 2015-03-04 Intermune Inc COMPOUNDS AS LYSOPHOSPHIC ACID RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
IL236088A0 (en) 2015-02-01
CL2014003243A1 (es) 2015-03-20
KR20150021057A (ko) 2015-02-27
CR20140525A (es) 2015-01-12
EP2864300A1 (en) 2015-04-29
UA109868C2 (ru) 2015-10-12
WO2013189864A1 (en) 2013-12-27
BR112014030685A2 (pt) 2017-06-27
US9321738B2 (en) 2016-04-26
AU2013279512A1 (en) 2014-10-16
JP2015520202A (ja) 2015-07-16
CN104411692A (zh) 2015-03-11
MA37764A1 (fr) 2016-01-29
CO7131358A2 (es) 2014-12-01
CA2869541A1 (en) 2013-12-27
HK1206342A1 (en) 2016-01-08
EA201492285A1 (ru) 2015-04-30
PE20142448A1 (es) 2015-01-28
US20150133511A1 (en) 2015-05-14
IN2014DN09348A (ru) 2015-07-17
PH12014502789A1 (en) 2015-02-09
SG11201407220YA (en) 2014-12-30

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