MX2014003169A - Ligandos del receptor ep1. - Google Patents

Ligandos del receptor ep1.

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Publication number
MX2014003169A
MX2014003169A MX2014003169A MX2014003169A MX2014003169A MX 2014003169 A MX2014003169 A MX 2014003169A MX 2014003169 A MX2014003169 A MX 2014003169A MX 2014003169 A MX2014003169 A MX 2014003169A MX 2014003169 A MX2014003169 A MX 2014003169A
Authority
MX
Mexico
Prior art keywords
receptor
receptor ligands
refers
prophylaxis
selectivity
Prior art date
Application number
MX2014003169A
Other languages
English (en)
Other versions
MX346143B (es
Inventor
Jover Antoni Torrens
González Elena Carceller
Vidal Ramon Mercè
Frontera Francesc Xavier Caldentey
Garrido Antonio David Rodríguez
Solana Jordi Salas
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2014003169A publication Critical patent/MX2014003169A/es
Publication of MX346143B publication Critical patent/MX346143B/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención pertenece al campo de ligandos del receptor EP1. Más específicamente, se refiere a compuestos de fórmula general (I) que tienen gran afinidad y selectividad para el receptor EP1. La invención también se refiere al procedimiento para su preparación, a su uso como medicamento para el tratamiento y/o la profilaxis de enfermedades o trastornos mediados por el receptor EP1 así como a composiciones farmacéuticas que los comprenden.
MX2014003169A 2011-09-16 2012-09-14 Ligandos del receptor ep1. MX346143B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11382296A EP2570125A1 (en) 2011-09-16 2011-09-16 Ep1 receptor ligands
PCT/EP2012/068101 WO2013037960A1 (en) 2011-09-16 2012-09-14 Ep1 receptor ligands

Publications (2)

Publication Number Publication Date
MX2014003169A true MX2014003169A (es) 2014-04-25
MX346143B MX346143B (es) 2017-03-09

Family

ID=46851508

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003169A MX346143B (es) 2011-09-16 2012-09-14 Ligandos del receptor ep1.

Country Status (19)

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US (1) US9518015B2 (es)
EP (2) EP2570125A1 (es)
JP (1) JP6041880B2 (es)
KR (1) KR20140061475A (es)
CN (1) CN104220422B (es)
AR (1) AR092288A1 (es)
AU (1) AU2012307326A1 (es)
BR (1) BR112014006305A2 (es)
CA (1) CA2848786A1 (es)
CO (1) CO6970588A2 (es)
ES (1) ES2629481T3 (es)
HK (1) HK1201269A1 (es)
IL (1) IL231518A0 (es)
IN (1) IN2014MN00697A (es)
MA (1) MA35444B1 (es)
MX (1) MX346143B (es)
SG (1) SG11201400680RA (es)
TN (1) TN2014000112A1 (es)
WO (1) WO2013037960A1 (es)

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BR112016025048A2 (pt) 2014-05-01 2017-10-31 Novartis Ag compostos e composições como agonistas do receptor tipo toll7
CN106458874B (zh) 2014-05-23 2018-09-14 Fmc公司 甲磺酰肼化合物和用于制备4-芳酰基吡唑衍生物的区域选择性方法
CN103992319B (zh) * 2014-05-27 2015-09-16 天津市斯芬克司药物研发有限公司 一种吡啶羧酸类化合物的制备方法
WO2016014918A1 (en) * 2014-07-25 2016-01-28 Innov 17 Llc Benzimidazole retinoic acid receptor-related orphan receptor modulators and uses thereof
US20180221339A1 (en) * 2015-06-16 2018-08-09 Translatum Medicus, Inc. Compositions and methods for treating and diagnosing ocular disorders
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds
EP3990433A4 (en) 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
MX2023003995A (es) 2020-10-05 2023-06-12 Enliven Inc Compuestos de 5-y 6-azaindol para la inhibicion de tirosina cinasas bcr-abl.
CN114163438A (zh) * 2021-12-13 2022-03-11 无锡捷化医药科技有限公司 一种2-甲基-3-羰基吡唑并[4,3-c]吡啶-7-羧酸盐酸盐的制备方法

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Also Published As

Publication number Publication date
MA35444B1 (fr) 2014-09-01
IL231518A0 (en) 2014-04-30
US9518015B2 (en) 2016-12-13
EP2766344A1 (en) 2014-08-20
CO6970588A2 (es) 2014-06-13
AU2012307326A1 (en) 2014-03-27
IN2014MN00697A (es) 2015-07-03
KR20140061475A (ko) 2014-05-21
SG11201400680RA (en) 2014-06-27
CN104220422B (zh) 2017-11-07
EP2766344B1 (en) 2017-05-03
CN104220422A (zh) 2014-12-17
CA2848786A1 (en) 2013-03-21
EP2570125A1 (en) 2013-03-20
ES2629481T3 (es) 2017-08-10
TN2014000112A1 (en) 2015-07-01
AR092288A1 (es) 2015-04-15
US20140323475A1 (en) 2014-10-30
JP6041880B2 (ja) 2016-12-14
JP2014530184A (ja) 2014-11-17
MX346143B (es) 2017-03-09
WO2013037960A1 (en) 2013-03-21
BR112014006305A2 (pt) 2017-04-11
HK1201269A1 (en) 2015-08-28

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