MX2013012345A - Alfa glucosidasa acida modificada con procesamiento acelerado. - Google Patents
Alfa glucosidasa acida modificada con procesamiento acelerado.Info
- Publication number
- MX2013012345A MX2013012345A MX2013012345A MX2013012345A MX2013012345A MX 2013012345 A MX2013012345 A MX 2013012345A MX 2013012345 A MX2013012345 A MX 2013012345A MX 2013012345 A MX2013012345 A MX 2013012345A MX 2013012345 A MX2013012345 A MX 2013012345A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- gaa
- kda
- amino acids
- modified
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (2)
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| US201161478336P | 2011-04-22 | 2011-04-22 | |
| PCT/US2012/034479 WO2012145644A1 (en) | 2011-04-22 | 2012-04-20 | Modified acid alpha glucosidase with accelerated processing |
Publications (1)
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| MX2013012345A true MX2013012345A (es) | 2015-05-07 |
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| MX2013012345A MX2013012345A (es) | 2011-04-22 | 2012-04-20 | Alfa glucosidasa acida modificada con procesamiento acelerado. |
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| US (1) | US20140186326A1 (OSRAM) |
| EP (1) | EP2699676A1 (OSRAM) |
| JP (2) | JP2014513952A (OSRAM) |
| KR (1) | KR20140037082A (OSRAM) |
| CN (1) | CN103797115A (OSRAM) |
| AU (1) | AU2012245280A1 (OSRAM) |
| BR (1) | BR112013026976A2 (OSRAM) |
| CA (1) | CA2833371A1 (OSRAM) |
| CL (1) | CL2013003010A1 (OSRAM) |
| CO (1) | CO6811810A2 (OSRAM) |
| CR (1) | CR20130555A (OSRAM) |
| EC (1) | ECSP13013036A (OSRAM) |
| GT (1) | GT201300252A (OSRAM) |
| IL (1) | IL228871A0 (OSRAM) |
| MA (1) | MA35125B1 (OSRAM) |
| MX (1) | MX2013012345A (OSRAM) |
| NI (1) | NI201300110A (OSRAM) |
| PE (1) | PE20140617A1 (OSRAM) |
| PH (1) | PH12013502149A1 (OSRAM) |
| RU (1) | RU2013151875A (OSRAM) |
| SG (2) | SG194486A1 (OSRAM) |
| TN (1) | TN2013000427A1 (OSRAM) |
| WO (1) | WO2012145644A1 (OSRAM) |
| ZA (1) | ZA201307696B (OSRAM) |
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| WO2014130723A1 (en) | 2013-02-20 | 2014-08-28 | Valerion Therapeutics, Llc | Methods and compositions for treatment of pompe disease |
| DK3201320T5 (da) | 2014-09-30 | 2024-10-14 | Amicus Therapeutics Inc | Højpotent sur alfa-glucosidase med forbedrede carbohydrater |
| JP2018538008A (ja) * | 2015-11-06 | 2018-12-27 | バイオマリン ファーマシューティカル インコーポレイテッド | リソソーム酵素の取り込みを中和する抗体または他の因子の検出のための細胞ベースアッセイ |
| MX394968B (es) | 2015-12-30 | 2025-03-24 | Amicus Therapeutics Inc | Alfa-glucosidasa con mayor cantidad de acido para el tratamiento de la enfermedad de pompe. |
| CA3019128A1 (en) | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Formulations comprising recombinant acid alpha-glucosidase |
| KR102343162B1 (ko) * | 2016-03-30 | 2021-12-23 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 고 m6p 재조합 단백질의 선택 방법 |
| EP3293203A1 (en) | 2016-09-12 | 2018-03-14 | Genethon | Acid-alpha glucosidase variants and uses thereof |
| EP3293260A1 (en) | 2016-09-12 | 2018-03-14 | Genethon | Acid-alpha glucosidase variants and uses thereof |
| MX2019002842A (es) | 2016-09-12 | 2019-08-29 | Genethon | Variantes de alfa-glucosidasa acida y usos de las mismas. |
| EP3293259A1 (en) | 2016-09-12 | 2018-03-14 | Genethon | Acid-alpha glucosidase variants and uses thereof |
| SMT202300187T1 (it) | 2017-05-15 | 2023-07-20 | Amicus Therapeutics Inc | Alfa-glucosidasi acida umana ricombinante |
| CN110809583A (zh) | 2017-06-07 | 2020-02-18 | 瑞泽恩制药公司 | 用于内化酶的组合物和方法 |
| KR101942093B1 (ko) * | 2018-01-05 | 2019-01-24 | 인하대학교 산학협력단 | 만노시다제 억제제를 포함하는 고만노즈 타입 n-당쇄를 갖는 인간 리소좀 효소 생산용 조성물 |
| KR20200118151A (ko) | 2018-02-07 | 2020-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 치료 단백질 전달을 위한 방법 및 조성물 |
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| US20220331408A1 (en) | 2019-07-09 | 2022-10-20 | Genethon | Treatment of glycogen storage disease (gsd) |
| AU2020388634A1 (en) * | 2019-11-19 | 2022-06-23 | AskBio Inc. | Therapeutic adeno-associated virus comprising liver-specific promoters for treating Pompe disease and lysosomal disorders |
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| US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| US7001994B2 (en) | 2001-01-18 | 2006-02-21 | Genzyme Corporation | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins |
| JP4742191B2 (ja) * | 2001-06-14 | 2011-08-10 | 独立行政法人産業技術総合研究所 | 糖蛋白質およびその製造方法 |
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| US6835831B2 (en) | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
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| US20100196345A1 (en) | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
| CN101942442B (zh) | 2003-06-24 | 2013-10-09 | 建新公司 | 新的β-肌动蛋白和RPS21启动子及其应用 |
| ES2344302T3 (es) * | 2004-02-10 | 2010-08-24 | Zystor Therapeutics , Inc. | Alfa glucosidasa acida y fragmentos de la misma. |
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2012
- 2012-04-20 PE PE2013002377A patent/PE20140617A1/es not_active Application Discontinuation
- 2012-04-20 RU RU2013151875/10A patent/RU2013151875A/ru not_active Application Discontinuation
- 2012-04-20 KR KR1020137029936A patent/KR20140037082A/ko not_active Withdrawn
- 2012-04-20 AU AU2012245280A patent/AU2012245280A1/en not_active Abandoned
- 2012-04-20 WO PCT/US2012/034479 patent/WO2012145644A1/en not_active Ceased
- 2012-04-20 JP JP2014506579A patent/JP2014513952A/ja active Pending
- 2012-04-20 PH PH1/2013/502149A patent/PH12013502149A1/en unknown
- 2012-04-20 SG SG2013076526A patent/SG194486A1/en unknown
- 2012-04-20 US US14/113,360 patent/US20140186326A1/en not_active Abandoned
- 2012-04-20 EP EP12717025.6A patent/EP2699676A1/en not_active Withdrawn
- 2012-04-20 CN CN201280030662.2A patent/CN103797115A/zh active Pending
- 2012-04-20 SG SG10201605874TA patent/SG10201605874TA/en unknown
- 2012-04-20 BR BR112013026976A patent/BR112013026976A2/pt not_active IP Right Cessation
- 2012-04-20 MX MX2013012345A patent/MX2013012345A/es not_active Application Discontinuation
- 2012-04-20 CA CA2833371A patent/CA2833371A1/en not_active Abandoned
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2013
- 2013-10-14 IL IL228871A patent/IL228871A0/en unknown
- 2013-10-16 ZA ZA2013/07696A patent/ZA201307696B/en unknown
- 2013-10-16 NI NI201300110A patent/NI201300110A/es unknown
- 2013-10-17 CL CL2013003010A patent/CL2013003010A1/es unknown
- 2013-10-18 GT GT201300252A patent/GT201300252A/es unknown
- 2013-10-18 TN TNP2013000427A patent/TN2013000427A1/fr unknown
- 2013-10-29 CR CR20130555A patent/CR20130555A/es unknown
- 2013-11-14 MA MA36431A patent/MA35125B1/fr unknown
- 2013-11-20 CO CO13272849A patent/CO6811810A2/es not_active Application Discontinuation
- 2013-11-21 EC ECSP13013036 patent/ECSP13013036A/es unknown
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2012245280A1 (en) | 2013-11-07 |
| WO2012145644A1 (en) | 2012-10-26 |
| CA2833371A1 (en) | 2012-10-26 |
| MA35125B1 (fr) | 2014-05-02 |
| PE20140617A1 (es) | 2014-05-28 |
| CR20130555A (es) | 2013-12-09 |
| US20140186326A1 (en) | 2014-07-03 |
| NI201300110A (es) | 2014-02-28 |
| CL2013003010A1 (es) | 2014-03-07 |
| SG10201605874TA (en) | 2016-09-29 |
| KR20140037082A (ko) | 2014-03-26 |
| IL228871A0 (en) | 2013-12-31 |
| RU2013151875A (ru) | 2015-05-27 |
| GT201300252A (es) | 2015-02-09 |
| TN2013000427A1 (en) | 2015-03-30 |
| PH12013502149A1 (en) | 2019-09-02 |
| BR112013026976A2 (pt) | 2019-09-24 |
| CN103797115A (zh) | 2014-05-14 |
| EP2699676A1 (en) | 2014-02-26 |
| SG194486A1 (en) | 2013-12-30 |
| CO6811810A2 (es) | 2013-12-16 |
| ECSP13013036A (es) | 2015-04-30 |
| JP2014513952A (ja) | 2014-06-19 |
| ZA201307696B (en) | 2014-07-30 |
| JP2017035091A (ja) | 2017-02-16 |
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