MX2013010306A - Formulaciones de dispersion solida y metodos de uso de las mismas. - Google Patents
Formulaciones de dispersion solida y metodos de uso de las mismas.Info
- Publication number
- MX2013010306A MX2013010306A MX2013010306A MX2013010306A MX2013010306A MX 2013010306 A MX2013010306 A MX 2013010306A MX 2013010306 A MX2013010306 A MX 2013010306A MX 2013010306 A MX2013010306 A MX 2013010306A MX 2013010306 A MX2013010306 A MX 2013010306A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- solid dispersion
- dispersion formulations
- formulations
- diphenylpropanoyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Mechanical Engineering (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a formulaciones y métodos para incrementar la bio-disponibilidad de 1-(4-benzhidrilpiperazin-1-i1 )-3,3-difenilpropan-1-ona, 1-(3,3- difenilpropanoil)piperazina, o una sal de la misma. En particular, la formulación puede incluir uno o más polímeros de matriz farmacéuticamente aceptables para formar una dispersión sólida, v.gr., una dispersión secada por rocío o una extrusión fundida caliente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161450479P | 2011-03-08 | 2011-03-08 | |
US201161485405P | 2011-05-12 | 2011-05-12 | |
PCT/US2012/028088 WO2012122279A1 (en) | 2011-03-08 | 2012-03-07 | Solid dispersion formulations and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013010306A true MX2013010306A (es) | 2013-12-09 |
Family
ID=46798550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013010306A MX2013010306A (es) | 2011-03-08 | 2012-03-07 | Formulaciones de dispersion solida y metodos de uso de las mismas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US8591944B2 (es) |
EP (1) | EP2654726A4 (es) |
JP (1) | JP2014507424A (es) |
KR (1) | KR20140011366A (es) |
CN (1) | CN103491964A (es) |
AU (1) | AU2012225459A1 (es) |
BR (1) | BR112013022788A2 (es) |
CA (1) | CA2828610A1 (es) |
MX (1) | MX2013010306A (es) |
WO (1) | WO2012122279A1 (es) |
Families Citing this family (25)
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IN2015DN03135A (es) * | 2012-09-28 | 2015-10-02 | Oncoethix Sa | |
KR102191562B1 (ko) | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
DE202012012130U1 (de) | 2012-12-19 | 2014-03-21 | Aquanova Ag | Curcuminsolubilisat |
US10016508B2 (en) | 2013-06-03 | 2018-07-10 | Shin-Etsu Chemical Co., Ltd. | Composition for hot-melt extrusion and method for producing hot-melt extrusion product using same |
EP3763702B1 (en) * | 2013-07-19 | 2023-12-13 | Siga Technologies, Inc. | Preparation of amorphous tecovirimat dispersions |
EP2837391B1 (en) | 2013-08-12 | 2017-05-10 | Shin-Etsu Chemical Co., Ltd. | Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate |
CN106102744A (zh) * | 2014-01-09 | 2016-11-09 | 维瑞斯特姆股份有限公司 | 用于治疗异常细胞生长的组合物和方法 |
AU2015214502B2 (en) * | 2014-02-05 | 2019-06-06 | Merck Sharp & Dohme Llc | Tablet formulation for CGRP-active compounds |
ES2907285T3 (es) * | 2014-03-06 | 2022-04-22 | Elanco Animal Health Incorporated | Composiciones de grapiprant y procedimientos de uso de las mismas |
KR101499867B1 (ko) * | 2014-04-22 | 2015-03-06 | 에스케이케미칼주식회사 | 활성 성분 (i) 함유 조성물 및 이의 제조 방법 |
KR101722564B1 (ko) * | 2014-09-16 | 2017-04-03 | 강원대학교산학협력단 | 수-난용성 약물을 포함하는 고체분산체 |
US11089804B2 (en) | 2014-12-11 | 2021-08-17 | Shin-Etsu Chemical Co., Ltd. | Oil-in-water type composition and food using same |
EP3307246A1 (en) * | 2015-06-09 | 2018-04-18 | Capsugel Belgium NV | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
CN107028931A (zh) | 2016-02-04 | 2017-08-11 | 上海宣泰医药科技有限公司 | 一种紫杉醇药物组合物及其药物制剂、制备方法和用途 |
CN107126419B (zh) * | 2016-02-26 | 2020-06-19 | 石药集团中诺药业(石家庄)有限公司 | 一种奥贝胆酸片剂及其制备方法 |
CN105816423B (zh) * | 2016-03-16 | 2018-07-20 | 福建天泰医药科技有限公司 | 依达拉奉剂型 |
CN105997883A (zh) * | 2016-05-06 | 2016-10-12 | 杭州容立医药科技有限公司 | 一种固体分散体及其制备方法和应用 |
CN105832672A (zh) * | 2016-05-06 | 2016-08-10 | 杭州容立医药科技有限公司 | 一种固体分散体的制备方法和应用 |
JP7112333B2 (ja) * | 2016-05-09 | 2022-08-03 | ディスパーソル テクノロジーズ リミテッド ライアビリティ カンパニー | 改善された薬物製剤 |
US10723807B2 (en) | 2017-03-31 | 2020-07-28 | Shin-Etsu Chemical Co., Ltd. | Method for producing hydroxyalkyl alkyl cellulose |
ES2886842T3 (es) * | 2017-04-13 | 2021-12-21 | Jean Paul Remon | Composiciones a base de xanthohumol |
MX2021001063A (es) * | 2018-07-30 | 2021-04-12 | Chugai Pharmaceutical Co Ltd | Dispersion solida de derivado de hidantoina. |
AU2020353381A1 (en) * | 2019-09-23 | 2022-04-07 | Bionomics Limited | Therapeutic formulations and uses thereof |
WO2022140537A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
EP4119128A1 (en) * | 2021-07-13 | 2023-01-18 | Dr. Falk Pharma Gmbh | Pharmaceutical composition for the oral administration of poorly soluble drugs comprising an amorphous solid dispersion |
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-
2012
- 2012-03-07 MX MX2013010306A patent/MX2013010306A/es not_active Application Discontinuation
- 2012-03-07 CN CN201280005886.8A patent/CN103491964A/zh active Pending
- 2012-03-07 BR BR112013022788A patent/BR112013022788A2/pt not_active IP Right Cessation
- 2012-03-07 JP JP2013551440A patent/JP2014507424A/ja active Pending
- 2012-03-07 CA CA2828610A patent/CA2828610A1/en not_active Abandoned
- 2012-03-07 WO PCT/US2012/028088 patent/WO2012122279A1/en active Application Filing
- 2012-03-07 US US13/414,369 patent/US8591944B2/en not_active Expired - Fee Related
- 2012-03-07 AU AU2012225459A patent/AU2012225459A1/en not_active Abandoned
- 2012-03-07 KR KR1020137026371A patent/KR20140011366A/ko not_active Application Discontinuation
- 2012-03-07 EP EP12754568.9A patent/EP2654726A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN103491964A (zh) | 2014-01-01 |
BR112013022788A2 (pt) | 2016-12-06 |
AU2012225459A1 (en) | 2013-10-10 |
JP2014507424A (ja) | 2014-03-27 |
US8591944B2 (en) | 2013-11-26 |
CA2828610A1 (en) | 2012-09-13 |
EP2654726A1 (en) | 2013-10-30 |
KR20140011366A (ko) | 2014-01-28 |
EP2654726A4 (en) | 2013-10-30 |
WO2012122279A1 (en) | 2012-09-13 |
US20130035345A1 (en) | 2013-02-07 |
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