MX2013007057A - Metodos para producir composiciones farmaceuticas estabilizadas de dosis solida que contienen morfinanos. - Google Patents
Metodos para producir composiciones farmaceuticas estabilizadas de dosis solida que contienen morfinanos.Info
- Publication number
- MX2013007057A MX2013007057A MX2013007057A MX2013007057A MX2013007057A MX 2013007057 A MX2013007057 A MX 2013007057A MX 2013007057 A MX2013007057 A MX 2013007057A MX 2013007057 A MX2013007057 A MX 2013007057A MX 2013007057 A MX2013007057 A MX 2013007057A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- pharmaceutical compositions
- solid dosage
- compositions containing
- producing stabilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Abstract
Se proporcionan métodos para producir composiciones farmacéuticas estabilizadas en forma de dosis sólida. En particular, se proporcionan métodos para preparar gránulos protegidos que contienen morfinano, y composiciones farmacéuticas en forma de dosis sólida producidas usando los gránulos protegidos de morfinano.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/973,962 US20110150989A1 (en) | 2009-12-22 | 2010-12-21 | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
PCT/US2010/061400 WO2011087765A2 (en) | 2009-12-22 | 2010-12-21 | Methods of producing stabilized solid pharmaceutical compositions containing morphinans |
PCT/US2011/041533 WO2012087377A1 (en) | 2010-12-21 | 2011-06-22 | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013007057A true MX2013007057A (es) | 2013-12-02 |
Family
ID=46318749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007057A MX2013007057A (es) | 2010-12-21 | 2011-06-22 | Metodos para producir composiciones farmaceuticas estabilizadas de dosis solida que contienen morfinanos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110150989A1 (es) |
EP (1) | EP2654727A1 (es) |
JP (2) | JP5897036B2 (es) |
KR (1) | KR101748906B1 (es) |
CN (1) | CN103402499B (es) |
AU (1) | AU2011345329B2 (es) |
BR (1) | BR112013015622A2 (es) |
CA (1) | CA2822553A1 (es) |
MX (1) | MX2013007057A (es) |
RU (1) | RU2013132138A (es) |
WO (1) | WO2012087377A1 (es) |
ZA (1) | ZA201303988B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
AU2009223061B2 (en) * | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
CN102596252A (zh) * | 2009-08-31 | 2012-07-18 | 蒂宝制药公司 | 用于对乙酰氨基酚的立即和延长释放的胃滞留药物组合物 |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
NZ603170A (en) | 2010-05-10 | 2015-04-24 | Euro Celtique Sa | Combination of active loaded granules with additional actives |
JP5838199B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス.エイ. | 活性剤を含まない顆粒およびその顆粒を含む錠剤の製造 |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US20150174075A2 (en) * | 2012-03-29 | 2015-06-25 | Daicel Corporation | Method for producing disintegrating particulate composition comprising acid-type carboxymethylcellulose, disintegrating particulate composition comprising acid-type carboxymethylcellulose, and orally disintegrating tablet including disintegrating particulate composition comprising acid-type carboxymethylcellulose |
US8815911B2 (en) | 2012-05-02 | 2014-08-26 | Orexo Ab | Alfentanil composition for the treatment of acute pain |
CN104010663B (zh) | 2012-09-20 | 2021-02-19 | 株式会社大赛璐 | 含酸式羧甲基纤维素和结晶纤维素的崩解性颗粒组合物及含该组合物的口腔内崩解片剂 |
CA2881144A1 (en) * | 2012-11-09 | 2014-05-09 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
CN103432107A (zh) * | 2013-08-20 | 2013-12-11 | 安徽省先锋制药有限公司 | 一种盐酸他喷他多对乙酰氨基酚口腔崩解片及其制备方法 |
JP6476122B2 (ja) * | 2013-09-27 | 2019-02-27 | 株式会社ダイセル | 二段階の湿式造粒工程で製造される崩壊性粒子組成物及び該組成物を含む口腔内崩壊錠剤 |
MX2016006279A (es) | 2013-11-13 | 2016-09-07 | Euro Celtique Sa | Hidromorfona y naloxona para el tratamiento del dolor y el sindrome de disfuncion intestinal opiacea. |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US10828257B2 (en) | 2014-04-21 | 2020-11-10 | Daicel Corporation | Disintegrating particle composition including microfibrous cellulose |
DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
US20180200190A1 (en) * | 2015-07-10 | 2018-07-19 | Sun Pharma Advanced Research Company Ltd. | Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US20190070120A1 (en) * | 2016-03-10 | 2019-03-07 | Aurobindo Pharma Ltd. | Pharmaceutical Composition Comprising Canagliflozin, Process of Preparation and Use Thereof |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
CN107488146B (zh) * | 2017-05-18 | 2020-05-22 | 中国科学院兰州化学物理研究所 | 异紫堇碱衍生物及其制备方法和应用 |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
CN108524460B (zh) * | 2018-05-14 | 2021-01-01 | 佛山市南海东方澳龙制药有限公司 | 烯啶虫胺双层片 |
CN109512796A (zh) * | 2018-12-26 | 2019-03-26 | 甘肃普安制药股份有限公司 | 一种氨酚羟考酮胶囊填充方法 |
WO2021090177A1 (en) * | 2019-11-04 | 2021-05-14 | Sun Pharmaceutical Industries Limited | Compounds for treatment of dengue infection |
CN111789818B (zh) * | 2020-08-15 | 2022-02-22 | 山东北大高科华泰制药有限公司 | 注射用盐酸罂粟碱药物组合物及制备方法 |
CN114748436B (zh) * | 2022-05-30 | 2023-05-16 | 迪沙药业集团有限公司 | 一种硝苯地平组合物及其制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1261260A (en) * | 1984-04-16 | 1989-09-26 | Anil Salpekar | Directly compressible codeine salt compositions |
US4851226A (en) * | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
US5075114A (en) * | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
GB9523752D0 (en) * | 1995-11-21 | 1996-01-24 | Pfizer Ltd | Pharmaceutical formulations |
SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
EP2295043A1 (en) * | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
KR101167465B1 (ko) * | 2000-10-30 | 2012-07-27 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
CA2409552A1 (en) * | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
FR2855756B1 (fr) * | 2003-06-06 | 2005-08-26 | Ethypharm Sa | Comprime orodispersible multicouche |
US20080031901A1 (en) * | 2004-09-24 | 2008-02-07 | Abbott Laboratories | Sustained release monoeximic formulations of opioid and nonopioid analgesics |
MXPA06003452A (es) * | 2003-09-26 | 2006-08-31 | Johnson & Johnson | Formulaciones de liberacion controlada que exhiben una velocidad de liberacion ascendente. |
CA2546691A1 (en) * | 2003-10-29 | 2005-05-12 | Alza Corporation | Once-a-day, oral, controlled-release, oxycodone dosage forms |
TWI350762B (en) * | 2004-02-12 | 2011-10-21 | Euro Celtique Sa | Particulates |
EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
FR2898056B1 (fr) * | 2006-03-01 | 2012-01-20 | Ethypharm Sa | Comprimes resistant a l'ecrasement destines a eviter le detournement illicite |
WO2007103113A2 (en) * | 2006-03-06 | 2007-09-13 | Pozen Inc. | Dosage forms for administering combinations of drugs |
US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
DK2046300T3 (da) * | 2006-08-04 | 2010-07-26 | Ethypharm Sa | Oralt desintegrerende multilagstablet |
WO2008015220A1 (en) * | 2006-08-04 | 2008-02-07 | Ethypharm | Granule and orally disintegrating tablet comprising oxycodone |
GB0625646D0 (en) * | 2006-12-21 | 2007-01-31 | Jagotec Ag | Improvements in or relating to organic compounds |
EP2200593B1 (en) * | 2007-09-13 | 2016-08-24 | Cima Labs Inc. | Abuse resistant drug formulation |
US8372432B2 (en) * | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
AU2009223061B2 (en) * | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8597681B2 (en) * | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
-
2010
- 2010-12-21 US US12/973,962 patent/US20110150989A1/en not_active Abandoned
-
2011
- 2011-06-22 JP JP2013546107A patent/JP5897036B2/ja not_active Expired - Fee Related
- 2011-06-22 AU AU2011345329A patent/AU2011345329B2/en not_active Ceased
- 2011-06-22 RU RU2013132138/15A patent/RU2013132138A/ru unknown
- 2011-06-22 CN CN201180068100.2A patent/CN103402499B/zh not_active Expired - Fee Related
- 2011-06-22 EP EP11731589.5A patent/EP2654727A1/en not_active Withdrawn
- 2011-06-22 MX MX2013007057A patent/MX2013007057A/es unknown
- 2011-06-22 BR BR112013015622A patent/BR112013015622A2/pt not_active IP Right Cessation
- 2011-06-22 KR KR1020137019037A patent/KR101748906B1/ko active IP Right Grant
- 2011-06-22 CA CA2822553A patent/CA2822553A1/en not_active Abandoned
- 2011-06-22 WO PCT/US2011/041533 patent/WO2012087377A1/en active Application Filing
-
2013
- 2013-05-31 ZA ZA2013/03988A patent/ZA201303988B/en unknown
-
2015
- 2015-08-05 JP JP2015154715A patent/JP2015193668A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20140021992A (ko) | 2014-02-21 |
ZA201303988B (en) | 2014-02-26 |
WO2012087377A1 (en) | 2012-06-28 |
AU2011345329B2 (en) | 2017-04-20 |
EP2654727A1 (en) | 2013-10-30 |
US20110150989A1 (en) | 2011-06-23 |
RU2013132138A (ru) | 2015-01-27 |
JP2015193668A (ja) | 2015-11-05 |
CN103402499A (zh) | 2013-11-20 |
BR112013015622A2 (pt) | 2019-09-24 |
JP5897036B2 (ja) | 2016-03-30 |
JP2014500315A (ja) | 2014-01-09 |
CA2822553A1 (en) | 2012-06-28 |
KR101748906B1 (ko) | 2017-06-19 |
CN103402499B (zh) | 2016-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2013007057A (es) | Metodos para producir composiciones farmaceuticas estabilizadas de dosis solida que contienen morfinanos. | |
ZA201601534B (en) | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses | |
GB201106750D0 (en) | Novel compounds | |
UA109464C2 (uk) | Спірооксіндольні антагоністи mdm2 | |
GB201106743D0 (en) | Novel compounds | |
TN2012000161A1 (en) | Spiro-oxindole mdm2 antagonists | |
MX346375B (es) | Antagonistas de espiro-oxindol de mdm2. | |
WO2012024620A3 (en) | Autotaxin inhibitors and uses thereof | |
MY162411A (en) | Crystalline forms of a macrolide, and uses therefor | |
NZ709958A (en) | Enhanced stability of novel liquid compositions | |
MX348823B (es) | Formulaciones estables de linaclotida. | |
ZA201209739B (en) | Levocarrimycin,pharmaceutical compositions,preparation methods and uses thereof | |
WO2012174158A3 (en) | Administration of benzodiazepine | |
EP2447253A4 (en) | DIHYDROPYRIMIDIN COMPOUNDS AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | |
MX347734B (es) | Anticuerpos anti-s100a4 y usos aplicaciones terapéuticas. | |
IL226094A0 (en) | The history of pyrazine, their preparation and pharmaceutical preparations containing them | |
WO2011104652A3 (en) | Veterinary compositions | |
TN2012000488A1 (en) | Pharmaceutical compositions comprising hydromorphone and naloxone | |
IN2012DN02793A (es) | ||
EP2560614A4 (en) | PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THEIR ADMINISTRATION | |
WO2011087765A3 (en) | Methods of producing stabilized solid pharmaceutical compositions containing morphinans | |
ZA201209674B (en) | Pharmaceutical compositions comprising paracetamol and process for preparing the same | |
EP2704570A4 (en) | ACTIVE SUBSTANCES, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF | |
MX2014006201A (es) | Formas de dosificaciones solidas de imatinib reconstituidas justo antes de usarse. | |
MX367773B (es) | Forma salina sólida de la alfa-6-mpeg6-o-hidroxicodona como agonistas opioides y sus usos. |